A Regularized Bayesian Dirichlet-multinomial Regression Model for Integrating Single-cell-level Omics and Patient-level Clinical Study Data DOI Creative Commons

Yanghong Guo,

Lei Yu, Lei Guo

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 6, 2024

Summary The abundance of various cell types can vary significantly among patients with varying phenotypes and even those the same phenotype. Recent scientific advancements provide mounting evidence that other clinical variables, such as age, gender, lifestyle habits, also influence certain types. However, current methods for integrating single-cell-level omics data variables are inadequate. In this study, we propose a regularized Bayesian Dirichlet-multinomial regression framework to investigate relationship between single-cell RNA sequencing patient-level data. Additionally, model employs novel hierarchical tree structure identify relationships at different cell-type levels. Our successfully uncovers significant associations specific across three distinct diseases: pulmonary fibrosis, COVID-19, non-small lung cancer. This integrative analysis provides biological insights could potentially inform interventions diseases.

Язык: Английский

Insights into IL-6/JAK/STAT3 Signaling in the Tumor Microenvironment: Implications for Cancer Therapy DOI

Win Lwin Thuya,

Yang Cao,

Paul Chi-Lui Ho

и другие.

Cytokine & Growth Factor Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

4
Regulatory T cells in immune checkpoint blockade antitumor therapy DOI Creative Commons

An Zhang,

Tao Fan,

Yixiao Liu

и другие.

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Ноя. 8, 2024

Regulatory T cells (Tregs), an essential component of the human immune system, are a heterogeneous group lymphocytes with ability to suppress responses and maintain homeostasis. Recent evidence indicates that Tregs may impair antitumor immunity facilitate cancer progression by weakening functions effector (Teffs). Consequently, targeting eliminate them from tumor microenvironments improve Teffs' activity could emerge as effective strategy for immunotherapy. This review outlines biology Tregs, detailing their origins, classification, crucial markers. Our focus lies on complex role in cancer's development, treatment, particularly suppressive upon via multiple mechanisms. We delve into Tregs' involvement checkpoint blockade (ICB) therapy, dual effect immunotherapy potential biomarkers ICB therapy effectiveness. also summarize advances therapies adjust optimize which be devising innovative treatment strategies.

Язык: Английский

Процитировано

14
CD4+ T cells in antitumor immunity DOI Creative Commons
Elena Montauti, David Y. Oh, Lawrence Fong

и другие.

Trends in cancer, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

12
Microbiome and pancreatic cancer: time to think about chemotherapy DOI Creative Commons
Juliana de Castilhos,

Katharina Tillmanns,

J. A. BLESSING

и другие.

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Июль 18, 2024

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer characterized by late diagnosis, rapid progression, and high mortality rate. Its complex biology, dense, stromal tumor environment with an immunosuppressive milieu, contributes to resistance against standard treatments like chemotherapy radiation. This comprehensive review explores the dynamic role of microbiome in modulating efficacy outcomes PDAC. It delves into microbiome's impact on drug metabolism resistance, interaction between microbial elements, drugs, human biology. We also highlight significance specific bacterial species enzymes influencing action immune response microenvironment. Cutting-edge methodologies, including artificial intelligence, low-biomass analysis patient-derived organoid models, are discussed, offering insights nuanced interactions microbes cells. The potential microbiome-based interventions as adjuncts conventional PDAC paving way for personalized therapy approaches. synthesizes recent research provide in-depth understanding how affects efficacy. focuses elucidating key mechanisms identifying existing knowledge gaps. Addressing these gaps crucial enhancing medicine refining treatment strategies, ultimately improving patient outcomes.

Язык: Английский

Процитировано

9
Development of NR0B2 as a therapeutic target for the re-education of tumor associated myeloid cells DOI Creative Commons
Hashni Epa Vidana Gamage,

Samuel T Albright,

Amanda Smith

и другие.

Cancer Letters, Год журнала: 2024, Номер 597, С. 217086 - 217086

Опубликована: Июнь 28, 2024

Immune checkpoint blockade (ICB) has had limited utility in several solid tumors such as breast cancer, a major cause of cancer-related mortality women. Therefore, there is considerable interest alternate strategies to promote an anti-cancer immune response. A paper co-published this issue describes how NR0B2, protein involved cholesterol homeostasis, functions within myeloid cells modulate the inflammasome and reduce expansion immune-suppressive regulatory T (T

Язык: Английский

Процитировано

4
A Humanized Anti-B7H3×4-1BB Bispecific Antibody Exerts Potent Antitumor Effects through the Activation of Innate and Adaptive Immunity DOI
Feng‐Rong Wang, Qun Zhao, Wenting Liu

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 749, С. 151347 - 151347

Опубликована: Янв. 16, 2025

Язык: Английский

Процитировано

0
Unveiling the orchestration of T-cell dynamics: A comprehensive examination of their crucial role in revolutionizing immunotherapy for pancreatic and colon cancers DOI

Sridevi Mardham,

Soumya Dakshinamurthy

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 199 - 232

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Decoding the mechanisms behind second primary cancers DOI Creative Commons

Meiyuan Zeng,

Anqi Lin, Aimin Jiang

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 24, 2025

Язык: Английский

Процитировано

0
A regularized Bayesian Dirichlet-multinomial regression model for integrating single-cell-level omics and patient-level clinical study data DOI

Yanghong Guo,

Lei Yu, Lei Guo

и другие.

Biometrics, Год журнала: 2025, Номер 81(1)

Опубликована: Янв. 7, 2025

ABSTRACT The abundance of various cell types can vary significantly among patients with varying phenotypes and even those the same phenotype. Recent scientific advancements provide mounting evidence that other clinical variables, such as age, gender, lifestyle habits, also influence certain types. However, current methods for integrating single-cell-level omics data variables are inadequate. In this study, we propose a regularized Bayesian Dirichlet-multinomial regression framework to investigate relationship between single-cell RNA sequencing patient-level data. Additionally, model employs novel hierarchical tree structure identify relationships at different cell-type levels. Our successfully uncovers significant associations specific across three distinct diseases: pulmonary fibrosis, COVID-19, non-small lung cancer. This integrative analysis provides biological insights could potentially inform interventions diseases.

Язык: Английский

Процитировано

0
Morphofunctional changes in the immune system in colitis-associated colorectal cancer in tolerant and susceptible to hypoxia mice DOI Creative Commons
D. Sh. Dzhalilova, M. V. Silina, А. М. Косырева

и другие.

PeerJ, Год журнала: 2025, Номер 13, С. e19024 - e19024

Опубликована: Фев. 25, 2025

Background One of the effective strategies for treatment tumor diseases, including colitis-associated colorectal cancer (CAC), is immunotherapy. During inflammation, NF-κB activated, which connected with hypoxia-inducible factor—HIF, regulating immune cells functioning and influences CAC development. Organisms differ according to their hypoxia resistance HIF expression. Therefore, aim study was characterize thymus, spleen mesenteric lymph nodes morphofunctional features, as well changes in subpopulation composition peripheral blood tolerant susceptible C57Bl/6 mice CAC. Methods Hypoxia tolerance assessed by gasping time measurement hypobaric decompression chamber. Based on outcome, were assigned three groups characterized ‘tolerant hypoxia’, ‘normal’, ‘susceptible hypoxia’. A month after determining modeled intraperitoneal azoxymethane (AOM) administration cycles dextran sulfate sodium consumption. Mice sacrificed 141st day AOM administration, a morphological, morphometric immunohistochemical tumors, morphological thymus spleen, assessment carried out. Results Tumors represented glandular intraepithelial neoplasia adenocarcinomas, area larger mice. Immunohistochemical revealed more pronounced Ki-67+ staining tumors In CAC, only mice, expansion thymic cortex observed relative control group, while ones, no detected. Only germinal centers lymphoid follicles enlargement observed. during comparison absolute number B-lymphocytes relative—cytotoxic T-lymphocytes increased. The cytotoxic NK higher compared ones. revealed—only them cells, increased, macrophages decreased. Conclusions Morphofunctional differences reactions indicated response development should be taken into account experimental studies.

Язык: Английский

Процитировано

0