The Potential of Mesenchymal Stem Cells in Treating Spinocerebellar Ataxia: Advances and Future Directions DOI Creative Commons

Gi Beom Lee,

Saeyoung Park, Un Ju Jung

и другие.

Biomedicines, Год журнала: 2024, Номер 12(11), С. 2507 - 2507

Опубликована: Ноя. 1, 2024

Spinocerebellar ataxia (SCA) is a heterogeneous disorder characterized by impaired balance and coordination caused cerebellar dysfunction. The absence of treatments approved the U.S. Food Drug Administration for SCA has driven investigation alternative therapeutic strategies, including stem cell therapy. Mesenchymal cells (MSCs), known their multipotent capabilities, have demonstrated significant potential in treating SCA. This review examines how MSCs may promote neuronal growth, enhance synaptic connectivity, modulate brain inflammation. Recent findings from preclinical clinical studies are also reviewed, emphasizing promise MSC therapy addressing unmet needs patients. Furthermore, ongoing trials future directions proposed to address limitations current approaches.

Язык: Английский

Potential therapeutic effect of dimethyl fumarate on Treg/Th17 cell imbalance in biliary atresia DOI
Mengting Liu, Ye Zhu,

Weida Meng

и другие.

Clinical Immunology, Год журнала: 2025, Номер unknown, С. 110439 - 110439

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders DOI
Azhagu Madhavan Sivalingam

Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)

Опубликована: Фев. 11, 2025

Язык: Английский

Процитировано

0
Umbilical mesenchymal stem cells mitigate T-cell compartments shift and Th17/Treg imbalance in acute ischemic stroke via mitochondrial transfer DOI Creative Commons
Shuna Chen, Chao Han, Zihan Shi

и другие.

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Март 12, 2025

Acute ischemic stroke (AIS) initiates secondary injuries that worsen neurological damage and hinder recovery. While peripheral immune responses play a key role in outcomes, clinical results from immunotherapy have been suboptimal, with limited focus on T-cell dynamics. Umbilical mesenchymal stem cells (UMSCs) offer therapeutic potential due to their immunomodulatory properties. They can regulate reduce neuroinflammation, potentially enhancing recovery by fostering pro-regenerative environment. However, the effect of UMSCs dynamics AIS remains underexplored. This study investigates following examines how may mitigate dysregulation develop better treatment strategies. patients (NIHSS scores 0–15) were recruited within 72 h onset, blood samples collected Day 0 (enrollment) 7. compartments identified flow cytometry, plasma cytokine levels quantified using cytometric bead array (CBA). Mitochondria labeled MitoTracker. Peripheral mononuclear isolated, treated lipopolysaccharide (LPS), cocultured both direct contact Transwell systems. Flow CBA, RT-qPCR, immunofluorescence assays used detect compartments, gene expression markers for helper T (Th) cell differentiation, profiles, mitochondrial transfer, reactive oxygen species (ROS) production, membrane potential. Additionally, DNA was depleted. The effects mitochondria-depleted mice compared through behavioral assessments analysis microenvironment. In AIS, underwent phenotypic shift naïve effector or memory states, specific increase Th17 decrease regulatory cells, leading alterations T-cell-mediated functions. an ex vivo co-culture system, LPS stimulation further amplified these disparities, inducing dysfunction oxidative stress cells. Notably, restored function reversed transfer. Critically, UMSC significantly improved deficits disorders mice, whereas failed produce this effect. Our comprehensive insights into attributes acute mechanisms provide crucial theoretical foundation understanding treatment.

Язык: Английский

Процитировано

0
Mesenchymal stem cell-derived extracellular vesicles in systemic sclerosis: role and therapeutic directions DOI Creative Commons
Xuan Wang,

Jiaying Guo,

Qinggang Dai

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Окт. 17, 2024

Systemic sclerosis (SSc) is a complex autoimmune disease with clinical symptoms of vascular damage, immune disorders, and fibrosis, presenting significant treatment challenges limited therapeutic options. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been demonstrated in numerous studies as more effective than MSCs treating diseases. Recent demonstrate that MSC-EVs can significantly ameliorate the SSc mitigate pathological changes such injury, dysregulation, fibrosis. These findings underscore promising potential SSc. promote angiogenesis, modulate dysfunction, combat This article summarizes applications possible mechanisms for SSc, thereby offering novel direction

Язык: Английский

Процитировано

1
The Potential of Mesenchymal Stem Cells in Treating Spinocerebellar Ataxia: Advances and Future Directions DOI Creative Commons

Gi Beom Lee,

Saeyoung Park, Un Ju Jung

и другие.

Biomedicines, Год журнала: 2024, Номер 12(11), С. 2507 - 2507

Опубликована: Ноя. 1, 2024

Spinocerebellar ataxia (SCA) is a heterogeneous disorder characterized by impaired balance and coordination caused cerebellar dysfunction. The absence of treatments approved the U.S. Food Drug Administration for SCA has driven investigation alternative therapeutic strategies, including stem cell therapy. Mesenchymal cells (MSCs), known their multipotent capabilities, have demonstrated significant potential in treating SCA. This review examines how MSCs may promote neuronal growth, enhance synaptic connectivity, modulate brain inflammation. Recent findings from preclinical clinical studies are also reviewed, emphasizing promise MSC therapy addressing unmet needs patients. Furthermore, ongoing trials future directions proposed to address limitations current approaches.

Язык: Английский

Процитировано

0