Differential expression and pathological implications of Linc01089 and Linc01578 in acute myeloid leukemia
Gene Reports,
Год журнала:
2025,
Номер
38, С. 102129 - 102129
Опубликована: Янв. 6, 2025
Язык: Английский
Epidermal growth factor-mediated suppression of long noncoding RNA LINC01089 prevents proliferation, migration and invasion of epithelial ovarian cancer
Inorganic Chemistry Communications,
Год журнала:
2025,
Номер
unknown, С. 114027 - 114027
Опубликована: Фев. 1, 2025
Язык: Английский
Analysis of expression characteristics of ferroptosis-related lncRNAs in gastrointestinal cancer patients in Asia
Discover Oncology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 12, 2025
Asian
cancer
patients
have
become
the
highest
morbidity
and
mortality
group,
gastrointestinal
tumors
account
for
majority
of
them,
so
it
is
urgent
to
find
effective
targets.
Therefore,
ferroptosis-related
lncRNAs
models
were
established
predict
prognosis
clinical
immune
characteristics
GI
cancer.
RNA
sequencing
data
collected
from
TCGA
database
(LIHC,
STAD,
ESCA,
PAAD,
COAD,
CHOL,
READ)
with
in
Asia.
Download
ferrodroptosis
genes
FerrDb.
Through
R
language,
differential
identified,
prognostic
related
LncRNAs
screened,
risk
scores
obtained
by
formula
build
models.
Survival
analysis,
heat
map,
COX
regression
ROC
used
evaluate
model.
Establish
Nomogram
clinically
relevant
maps.
GSEA
software
was
analyze
gene
enrichment
immune-related
high
low
groups.
LncRNA
expression
validated
through
paired
sample
analysis
qRT-PCR,
drug
sensitivity
also
analyzed.
The
transcriptome
297
cases
322
downloaded
TCGA,
intersection
obtaine.
Cox
revealed
48
associated
prognosis.
survival
heatmap,
ROC,
found
that
model
highly
accurate
efficient
predicting
KEGG-related
showed
12
pathways
significantly
expressed
low-risk
group.
Four
functions
higher
high-risk
group
than
all
checkpoints
three
exhibited
varying
levels
across
different
data.
Our
results
reveal
innovative
strong
evidence
can
be
as
biomarkers
treatment
Язык: Английский
Interactions between long non-coding RNAs and m6 A modification in cancer
Discover Oncology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Апрель 20, 2025
Long
non-coding
RNAs
(lncRNAs)
are
a
class
of
transcripts
exceeding
200
nucleotides
(nt)
in
length,
which
broadly
implicated
broad
spectrum
physiological
and
pathological
processes,
including
allelic
imprinting,
genome
packaging,
chromatin
remodeling,
transcriptional
activation
disruption,
as
well
the
occurrence
progression
oncogenesis.
N6-methyladenosine
(m6
A)
methylation
stands
most
prevalent
RNA
modification,
affecting
multiple
facets
biology
such
stability,
splicing,
transport,
translation,
degradation,
tertiary
structure.
Aberrant
m6
A
modifications
intimately
cancer
progression.
In
recent
years,
there
has
been
growing
number
studies
illuminating
dynamic
interplay
between
lncRNAs
modifications,
revealing
that
can
modulate
activity
regulators,
while
not
only
affects
structural
integrity
but
also
translational
efficiency
stability
lncRNAs.
Together,
interactions
significantly
impact
downstream
oncogenes,
suppressor
genes,
cellular
metabolism,
epithelial-mesenchymal
transition,
angiogenesis,
drug
DNA
homology
repair,
epigenetics,
subsequently
influencing
tumorigenesis,
metastasis,
resistance.
This
article
endeavors
to
clarify
functions
mechanisms
interaction
provide
promising
insights
for
diagnosis
therapeutic
strategies.
Язык: Английский
Interplay of Transcriptomic Regulation, Microbiota, and Signaling Pathways in Lung and Gut Inflammation-Induced Tumorigenesis
Cells,
Год журнала:
2024,
Номер
14(1), С. 1 - 1
Опубликована: Дек. 24, 2024
Inflammation
can
positively
and
negatively
affect
tumorigenesis
based
on
the
duration,
scope,
sequence
of
related
events
through
regulation
signaling
pathways.
A
transcriptomic
analysis
five
pulmonary
arterial
hypertension,
twelve
Crohn’s
disease,
ulcerative
colitis
high
throughput
sequencing
datasets
using
R
language
specialized
libraries
gene
enrichment
analyses
identified
a
regulatory
network
in
each
inflammatory
disease.
IRF9
LINC01089
hypertension
are
to
pathways
like
MAPK,
NOTCH,
human
papillomavirus,
hepatitis
c
infection.
ZNF91
TP53TG1
disease
PPAR,
metabolic
ZNF91,
VDR,
DLEU1,
SATB2-AS1,
AMPK,
The
activation
might
be
interaction
characteristic
microbiota
with
lung
gut
cell
receptors
present
membrane
rafts
complexes.
highlights
impact
several
coding
non-coding
RNAs,
suggesting
their
relationship
unlocking
phenotypic
plasticity
for
acquisition
hallmarks
cancer
during
adaptation
phenotypes.
Язык: Английский