The Influence of Physical Exercise, Ketogenic Diet, and Time-Restricted Eating on De Novo Lipogenesis: A Narrative Review DOI Open Access
Antonio Paoli

Nutrients, Год журнала: 2025, Номер 17(4), С. 663 - 663

Опубликована: Фев. 13, 2025

De novo lipogenesis (DNL) is a metabolic pathway that converts carbohydrates into fatty acids, primarily occurring in the liver and, to lesser extent, adipose tissue. While hepatic DNL highly responsive dietary carbohydrate intake and regulated by insulin via transcription factors like SREBP-1c, more modest less sensitive overfeeding. Dysregulated contributes disorders, including dysfunction-associated steatotic disease (MASLD). Lifestyle interventions, such as physical exercise, ketogenic diets, time-restricted eating (TRE) offer promising strategies regulate improve health. Physical exercise enhances glucose uptake muscles, reduces levels, promotes lipid oxidation, thereby suppressing DNL. Endurance resistance training also mitochondrial function, further mitigating triglyceride accumulation. Ketogenic diets shift energy metabolism toward acid oxidation ketogenesis, lower insulin, directly downregulate lipogenic enzyme activity liver. TRE aligns feeding with circadian rhythms optimizing AMP-activated protein kinase (AMPK) activation during fasting periods, which suppresses metabolism. The combined effects of these interventions demonstrate significant potential for improving profiles, reducing triglycerides, preventing lipotoxicity. By addressing distinct roles DNL, target systemic localized dysregulation. Although research needed fully understand their long-term impact, findings highlight transformative integrating approaches clinical practice manage disorders associated complications.

Язык: Английский

The Effects of Time-Restricted Eating on Inflammation and Oxidative Stress in Overweight Older Adults: A Pilot Study DOI Open Access
Armin Ezzati, Javier Tamargo,

L. Golberg

и другие.

Nutrients, Год журнала: 2025, Номер 17(2), С. 322 - 322

Опубликована: Янв. 17, 2025

Time-restricted eating (TRE) has been associated with beneficial effects for inflammation and oxidative stress; however, the of TRE on stress in aging population have not explored. This secondary analysis tested pro-inflammatory (hs-CRP [high-sensitivity C-reactive protein], IL-1β [interleukin 1 beta], IL-6 6], TNF-α [tumor necrosis factor alpha]) (8-isoprostane) biomarkers ten overweight older adults (mean age = 77.1 ± 6.1 years; six women four men), who followed a protocol 16 h fasting per day consumed food ad libitum during an 8 window 4 weeks. levels decreased from 43.2 (11.2) pg/mL to 39.7 (10.0) Cohen's d effect size 0.33, 1.4 (0.8) 1.3 (0.6) 0.23, suggesting potential anti-inflammatory benefits. hs-CRP showed no substantial changes (Cohen's ≤ 0.03). The marker 8-isoprostane slightly 0.07. findings this pilot study provide initial insights into inflammatory markers adults. Given small sample short-term intervention, well-powered studies longer duration are needed better understand populations.

Язык: Английский

Процитировано

0
The Influence of Physical Exercise, Ketogenic Diet, and Time-Restricted Eating on De Novo Lipogenesis: A Narrative Review DOI Open Access
Antonio Paoli

Nutrients, Год журнала: 2025, Номер 17(4), С. 663 - 663

Опубликована: Фев. 13, 2025

De novo lipogenesis (DNL) is a metabolic pathway that converts carbohydrates into fatty acids, primarily occurring in the liver and, to lesser extent, adipose tissue. While hepatic DNL highly responsive dietary carbohydrate intake and regulated by insulin via transcription factors like SREBP-1c, more modest less sensitive overfeeding. Dysregulated contributes disorders, including dysfunction-associated steatotic disease (MASLD). Lifestyle interventions, such as physical exercise, ketogenic diets, time-restricted eating (TRE) offer promising strategies regulate improve health. Physical exercise enhances glucose uptake muscles, reduces levels, promotes lipid oxidation, thereby suppressing DNL. Endurance resistance training also mitochondrial function, further mitigating triglyceride accumulation. Ketogenic diets shift energy metabolism toward acid oxidation ketogenesis, lower insulin, directly downregulate lipogenic enzyme activity liver. TRE aligns feeding with circadian rhythms optimizing AMP-activated protein kinase (AMPK) activation during fasting periods, which suppresses metabolism. The combined effects of these interventions demonstrate significant potential for improving profiles, reducing triglycerides, preventing lipotoxicity. By addressing distinct roles DNL, target systemic localized dysregulation. Although research needed fully understand their long-term impact, findings highlight transformative integrating approaches clinical practice manage disorders associated complications.

Язык: Английский

Процитировано

0