Lipid metabolism in ferroptosis: mechanistic insights and therapeutic potential

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 11, 2025

Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, plays a pivotal role in various physiological and pathological processes. In this review, we summarize the core mechanisms ferroptosis, emphasizing its intricate connections to metabolism, including fatty acid synthesis, phospholipid remodeling, oxidation dynamics. We further highlight advancements detection technologies, such as fluorescence imaging, lipidomics, vivo PET which have deepened our understanding ferroptotic regulation. Additionally, discuss ferroptosis human diseases, where it acts double-edged sword, contributing cancer while also driving ischemia-reperfusion injury neurodegeneration. Finally, explore therapeutic strategies aimed at either inducing or inhibiting iron chelation, antioxidant modulation, lipid-targeted interventions. By integrating mechanistic insights, disease relevance, potential, review provides comprehensive perspective on crucial interface between metabolism oxidative stress.

Язык: Английский

Ferroptosis: a potential therapeutic target in cardio-cerebrovascular diseases

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Язык: Английский