Repositioning of drugs for the treatment of major depressive disorder based on prediction of drug-induced gene expression changes DOI
Sergey M. Ivanov, Alexey A. Lagunin, Vladimir Poroikov

и другие.

Biomeditsinskaya Khimiya, Год журнала: 2024, Номер 70(6), С. 403 - 412

Опубликована: Янв. 1, 2024

Major depressive disorder (MDD) is one of the most common diseases affecting millions people worldwide. The use existing antidepressants in many cases does not allow achieving stable remission, probably due to insufficient understanding pathological mechanisms. This indicates need for development more effective drugs based on in-depth MDD's pathophysiology. Since high costs and long duration new drugs, drug repositions may be promising alternative. In this study we have applied recently developed DIGEP-Pred approach identify that induce changes expression genes associated with etiopathogenesis MDD, followed by identification their potential MDD-related targets molecular mechanisms antidepressive effects. included following steps. First, using structure-activity relationships (SARs) predicted drug-induced gene 3690 worldwide approved drugs. Disease enrichment analysis allowed significantly altered known genes. Second, targets, which are probable master regulators responsible changes, been identified through SAR-based prediction network analysis. Only those whose were clearly MDD according published data, selected further Third, since must distribute into brain tissues, an oral route administration blood-brain barrier permeability was estimated available experimental data silico predictions. As a result, 19 can potentially repurposed treatment. These belong various therapeutic categories, including adrenergic/dopaminergic agents, antiemetics, antihistamines, antitussives, muscle relaxants. Many these experimentally confirmed or interactions well-known protein such as monoamine (serotonin, adrenaline, dopamine) acetylcholine receptors transporters well less trivial galanin receptor type 3 (GALR3), G-protein coupled estrogen 1 (GPER1), tyrosine-protein kinase JAK3, serine/threonine-protein ULK1. Importantly, act two produce stronger action achieve potent effect. Thus, revealed represent candidates treatment MDD.

Язык: Английский

Sex-specific associations of neurodegeneration and inflammatory biomarkers with intrinsic capacity in older adults: Findings from the 4-year longitudinal Multidomain Alzheimer's Prevention Trial (MAPT) DOI
Luana Caroline de Assunção Cortez Corrêa, Jérémy Raffin, Bruno Vellas

и другие.

Maturitas, Год журнала: 2025, Номер 193, С. 108191 - 108191

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

0
The Crucial Role of the Blood–Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications DOI Open Access
Sehwan Kim, Un Ju Jung, Sang Ryong Kim

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 386 - 386

Опубликована: Янв. 9, 2025

The blood-brain barrier (BBB) is a crucial structure that maintains brain homeostasis by regulating the entry of molecules and cells from bloodstream into central nervous system (CNS). Neurodegenerative diseases such as Alzheimer's Parkinson's disease, well ischemic stroke, compromise integrity BBB. This leads to increased permeability infiltration harmful substances, thereby accelerating neurodegeneration. In this review, we explore mechanisms underlying BBB disruption, including oxidative stress, neuroinflammation, vascular dysfunction, loss tight junction integrity, in patients with neurodegenerative diseases. We discuss how breakdown contributes neurotoxicity, abnormal accumulation pathological proteins, all which exacerbate neuronal damage facilitate disease progression. Furthermore, potential therapeutic strategies aimed at preserving or restoring function, anti-inflammatory treatments, antioxidant therapies, approaches enhance integrity. Given role neurodegeneration, maintaining its represents promising approach slow prevent progression

Язык: Английский

Процитировано

0
Association between serum inflammatory cytokines levels and post-stroke depression among stroke patients: A meta-analysis and systematic review DOI
Yao Zhou, Lijuan Zhao,

Yunzhu Tang

и другие.

Journal of Psychosomatic Research, Год журнала: 2025, Номер 190, С. 112050 - 112050

Опубликована: Фев. 11, 2025

Язык: Английский

Процитировано

0
Loteprednol etabonate alleviates NLRP3 inflammasome-associated inflammatory diseases in mice by suppressing the transcription of IL-1β DOI

L. Ye,

Wei‐Chen Huang, Weiling Li

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141644 - 141644

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Depression as a Risk Factor for Gynecological Cancers: Evidence from NHANES Data DOI Creative Commons
Chaoyi Wang, Jin Xu, Xiaodan Li

и другие.

International Journal of Women s Health, Год журнала: 2025, Номер Volume 17, С. 615 - 625

Опубликована: Март 1, 2025

Depression is one of the leading sources disease burden globally and plays a significant role in occurrence development many cancers, representing an important health risk. However, relationship between depression risk gynecologic cancers has not been fully assessed. This study aims to explore association cancers. We selected 11,574 participants from NHANES 2009-2018 cycles, among which 274 had cancer (GC), 137 cervical (CC), 48 ovarian (OC), 89 endometrial (EC). Box plots were used assess differences PHQ-9 scores non-cancer groups. Logistic regression models restricted cubic spline (RCS) employed evaluate Subgroup analyses interaction tests examined consistency across different characteristics. There was difference group group. In multivariable logistic analysis, positively correlated with GC, OC, EC, while no found CC Additionally, RCS model also indicated nonlinear subgroup suggested that OC consistent groups, whereas GC EC showed heterogeneity relation race marital status. Specifically, higher levels are associated increased Future attention should be given impact on incidence particularly EC.

Язык: Английский

Процитировано

0
Features of the course of menopause in women under chronic stress: An observational cohort study DOI Creative Commons

Tatiana L. Botasheva,

Il'ya Mikhaylovich Fabrikant, E. Yu. Lebedenko

и другие.

Kuban Scientific Medical Bulletin, Год журнала: 2024, Номер 31(4), С. 42 - 55

Опубликована: Авг. 23, 2024

Background. Functional processes in the female organism at stage of reproductive function failure menopause attract considerable interest researchers. The paper presents a study great medical, biological and social importance into women living territories with permanent military operations for long time and, thus, suffering from post-traumatic syndrome, which significantly affects character menopause. Objectives . To identify features menopausal syndrome who have been under chronic stress (6–8 years) zone ongoing operations, namely Donetsk Luhansk People’s Republics, Rostov Oblast — region free active operations. Methods. An observational cohort involved 60 (refugees), long-term residents without aged 50–65 years, clinical manifestations syndrome; all were patients Research Institute Obstetrics Pediatrics, State Medical University. In accordance Stages Reproductive Aging Workshop (STRAW+10) classification menopause, two groups ( n = 30) formed representatives each residence. Group I included 30 women, 50–55, had late transition (stage -1 STRAW+10) syndrome. II postmenopausal (stages +1 +2 STRAW+10), 60–65, 1 enrolled Oblast, group 2 Modified index was considered as main indicator study. Statistical data processing carried out by means Statistica 10.01 (StatSoft, USA), Microsoft Excel 2010 (Microsoft, IBM SPSS 24.0 (IBM, MedCalc (MedCalc Software, Belgium). Results. Long-term reported to develop more often. revealed statistically significant prevalence mild degree 63.3 % cases compared 36.7 similar severity Republics. Meanwhile, Republics indicated moderate 50.0 severe 33.3 postmenopause versus 23.4 10 respectively. intensity neurovegetative psycho-emotional disorders both regions increases aging process system appears most pronounced period. Conclusion. Residents live war are exposed constant threat life, intensifies modulates already existing functional hormonal restructuring brain subsystems during perimenopause. Non-uniform shifts different levels central nervous conditions lead change intracerebral an increase occurrence various dysfunctional deviations.

Язык: Английский

Процитировано

0
Unveiling proteomic targets in the hypothalamus of ovariectomized and estradiol-treated rats: Insights into menopausal syndrome mechanisms DOI
Yanrong Sun, Wenjuan Wang, Yao Li

и другие.

Annals of Anatomy - Anatomischer Anzeiger, Год журнала: 2024, Номер 257, С. 152341 - 152341

Опубликована: Сен. 24, 2024

Язык: Английский

Процитировано

0
Depression as a Risk Factor for Gynecological Cancers: Evidence from a National Study DOI Creative Commons
Chaoyi Wang, Jin Xu, Xiaodan Li

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 27, 2024

Abstract Background: Depression is one of the leading sources disease burden globally and plays a significant role in occurrence development many cancers, representing an important health risk. However, relationship between depression risk gynecologic cancers has not been fully assessed. Objective: This study aims to explore association cancers. Methods: The selected 11,574 participants from NHANES 2009-2018 cycles, among which 274 had cancer (GC), 137 cervical (CC), 48 ovarian (OC), 89 endometrial (EC). Box plots were used assess differences PHQ-9 scores non-cancer groups. Logistic regression models restricted cubic spline (RCS) employed evaluate Subgroup analyses interaction tests examined consistency across different characteristics. Results: There was difference group group. In multivariable logistic analysis, positively correlated with GC, OC, EC, while no found CC RCS model also indicated nonlinear association. Additionally, subgroup suggested that OC consistent groups, whereas GC EC showed heterogeneity relation race marital status. Conclusion: Depression Specifically, higher levels are associated increased Future attention should be given impact on incidence particularly EC.

Язык: Английский

Процитировано

0
Repositioning of drugs for the treatment of major depressive disorder based on prediction of drug-induced gene expression changes DOI
Sergey M. Ivanov, Alexey A. Lagunin, Vladimir Poroikov

и другие.

Biomeditsinskaya Khimiya, Год журнала: 2024, Номер 70(6), С. 403 - 412

Опубликована: Янв. 1, 2024

Major depressive disorder (MDD) is one of the most common diseases affecting millions people worldwide. The use existing antidepressants in many cases does not allow achieving stable remission, probably due to insufficient understanding pathological mechanisms. This indicates need for development more effective drugs based on in-depth MDD's pathophysiology. Since high costs and long duration new drugs, drug repositions may be promising alternative. In this study we have applied recently developed DIGEP-Pred approach identify that induce changes expression genes associated with etiopathogenesis MDD, followed by identification their potential MDD-related targets molecular mechanisms antidepressive effects. included following steps. First, using structure-activity relationships (SARs) predicted drug-induced gene 3690 worldwide approved drugs. Disease enrichment analysis allowed significantly altered known genes. Second, targets, which are probable master regulators responsible changes, been identified through SAR-based prediction network analysis. Only those whose were clearly MDD according published data, selected further Third, since must distribute into brain tissues, an oral route administration blood-brain barrier permeability was estimated available experimental data silico predictions. As a result, 19 can potentially repurposed treatment. These belong various therapeutic categories, including adrenergic/dopaminergic agents, antiemetics, antihistamines, antitussives, muscle relaxants. Many these experimentally confirmed or interactions well-known protein such as monoamine (serotonin, adrenaline, dopamine) acetylcholine receptors transporters well less trivial galanin receptor type 3 (GALR3), G-protein coupled estrogen 1 (GPER1), tyrosine-protein kinase JAK3, serine/threonine-protein ULK1. Importantly, act two produce stronger action achieve potent effect. Thus, revealed represent candidates treatment MDD.

Язык: Английский

Процитировано

0