Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction
Brain and Behavior,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Background
The
occurrence
and
development
of
postoperative
cognitive
dysfunction
(POCD)
are
closely
linked
to
neuroinflammation.
This
bibliometric
analysis
aims
provide
novel
insights
into
the
research
trajectory,
key
topics,
potential
future
trends
in
field
neuroinflammation‐induced
POCD.
Methods
Web
Science
Core
Collection
(WoSCC)
database
was
searched
identify
publications
from
2012
2023
on
Bibliometric
analysis,
involving
both
statistical
visual
analyses,
conducted
using
CiteSpace,
VOSviewer,
R
software.
Results
Research
POCD
has
exhibited
an
increasing
trend
over
past
12
years.
China
had
highest
number
publications,
Nanjing
Medical
University
most
collaboration
with
other
institutions,
Zhiyi
Zuo
published
author,
Journal
Neuroinflammation
served
as
primary
publication
frequent
keyword
Keyword
clustering
indicated
that
predominant
cluster
is
dexmedetomidine.
Burst
detection
revealed
delirium
(POD),
perioperative
neurocognitive
disorders
(PND),
apoptosis,
epigenetic
modifications
were
trends.
Conclusions
Our
identified
following
areas
associated
POCD:
anesthesia,
surgery,
dexmedetomidine,
NLRP3
inflammasome,
mechanism
topics
comprise
POD,
PND,
modifications.
Язык: Английский
Analysis of risk factors related to perioperative neurocognitive disorders in elderly patients with hip fractures
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 9, 2025
To
explore
the
risk
factors
related
to
perioperative
neurocognitive
disorders
(PND)
in
elderly
patients
with
hip
fractures,
acute
pain
management
as
core.
This
study
used
a
retrospective
case-control
method.
90
who
underwent
artificial
femoral
head
replacement
or
total
surgery
our
hospital
from
2022
2023
were
collected,
and
divided
into
PND
group
non-PND
based
on
occurrence
of
PND.
Collected
data
17
conducted
univariate
multivariate
regression
analysis
analyze
contribution
value
fractures.
Univariate
showed
that
compared
group,
significant
increase
age,
higher
ASA
class,
longer
surgical
time,
increased
number
nerve
block
cases,
postoperative
12
h
visual
analogue
scale
(VAS)
scores,
24
VAS
levels
CRP,
PCT,
BL-6
(P
<
0.05).
Multivariate
found
for
BL-6.
The
protective
class
III
II.
undergoing
fracture
included
scores
(OR
=
3.356),
2.311),
CRP
1.058),
PCT
18.661),
1.061).
0.039)
II
0.016).
Язык: Английский
Macrophage migration inhibitory factor in the mouse hippocampus promotes neuroinflammation and cognitive dysfunction following anesthesia and surgery
International Immunopharmacology,
Год журнала:
2025,
Номер
151, С. 114351 - 114351
Опубликована: Фев. 24, 2025
Язык: Английский
The regulatory mechanism of intermittent fasting and probiotics on cognitive function by the microbiota‐gut‐brain axis
Journal of Food Science,
Год журнала:
2025,
Номер
90(3)
Опубликована: Март 1, 2025
Abstract
Intermittent
fasting
(IF)
is
an
eating
pattern
that
promotes
health
and
cognitive
improvement
through
periodic
eating.
It
has
been
shown
to
enhance
neuroplasticity
reduce
oxidative
stress
inflammation.
Recent
studies
have
demonstrated
probiotic
supplementation
enhances
performance
by
modulating
gut
microbiota
composition
increasing
short‐chain
fatty
acid
production,
which
in
turn
neurogenesis
synaptic
plasticity.
The
microbiota‐gut‐brain
axis
(MGBA)
the
communication
bridge
between
brain,
influencing
function
immune,
endocrine,
nervous
systems.
combination
of
probiotics
IF
may
exert
complementary
effects
on
function,
with
enhancing
microbial
diversity
metabolic
efficiency,
while
further
modulate
barrier
integrity
neurotransmitter
synthesis.
This
review
critically
examines
interplay
via
MGBA,
identifying
key
mechanisms
potential
therapeutic
strategies
remain
underexplored
current
research.
Язык: Английский
How should clinicians interpret these results?
European Journal of Anaesthesiology,
Год журнала:
2025,
Номер
42(5), С. 385 - 388
Опубликована: Апрель 3, 2025
Язык: Английский
The association between migraine and gut microbiota: a systematic review
Acta Neurologica Belgica,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Recent
studies
suggest
a
link
between
gut
microbiota
and
neurological
diseases,
implicating
the
microbiome's
role
in
health.
However,
specific
alterations
microbiome
associated
with
migraine
remain
underexplored.
This
study
aims
to
systematically
review
existing
literature
determine
whether
patients
are
changes
composition.
A
systematic
was
conducted
accordance
PRISMA
statement.
We
included
original
empirical
investigating
patients.
Data
extracted
design,
participant
demographics,
differences
at
various
taxonomic
levels,
measures
of
microbial
diversity
(alpha
beta
diversity).
The
search
selection
process
involved
four
independent
reviewers
who
assessed
abstracts
full
texts
ensure
eligibility.
evaluated
using
relative
abundance
indices.
Six
studies,
encompassing
regions
including
China,
Korea,
Italy,
were
analysis.
results
indicated
significant
controls.
Key
findings
include
reduction
Faecalibacterium,
genus
known
for
its
anti-inflammatory
properties,
patients,
those
chronic
migraine.
Conversely,
Veillonella
exhibited
elevated
compared
Other
taxa,
such
as
Prevotella
Parabacteroides,
showed
variable
associations
across
different
suggesting
dysbiotic
environment
highlights
that
migraines
microbiota,
decreased
key
taxa.
These
dysbiosis
may
play
pathophysiology.
Further
research
is
needed
explore
potential
causal
relationships
therapeutic
implications,
particularly
targeting
management.
Язык: Английский
Risk Factors and Prediction Model for Post-operative Cognitive Dysfunction After Aneurysmal Subarachnoid Hemorrhage
Current Problems in Surgery,
Год журнала:
2025,
Номер
unknown, С. 101767 - 101767
Опубликована: Апрель 1, 2025
Язык: Английский
Intranasally Delivered Echinacoside Micelles Modulate Mitochondrial Fusion Against Postoperative Cognitive Dysfunction
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 30, 2025
Abstract
The
disruption
of
mitochondrial
homeostasis
in
neurons
accounts
for
the
onset
and
progression
postoperative
cognitive
dysfunction
(POCD).
Echinacoside
(ECH)
can
facilitate
fusion
to
mediate
neuroprotection,
but
its
therapeutic
efficacy
is
greatly
limited
by
inefficient
brain
accumulation
neuronal
delivery.
Herein,
ECH‐encapsulated
micelles
are
constructed
from
copolymer
containing
poly(carboxybetaine
methacrylate)
(PCBMA)
block
phenylboronic
acid
(PBA)‐modified
poly(dimethylamino)ethyl
methacrylate
block,
which
mediates
effective,
brain‐targeted
delivery
via
intranasal
administration.
In
POCD
mice,
efficiently
penetrate
nasal
mucosa
betaine
structure
PCBMA
that
be
recognized
betaine‐GABA
transporter
1
(BGT‐1)
on
epithelial
cells,
followed
into
hippocampus
through
submucosal
olfactory
trigeminal
nerve
pathways.
Subsequently,
internalized
BGT‐1‐mediated
endocytosis.
over‐produced
reactive
oxygen
species
inside
trigger
dissociation
ECH
release,
thereby
inducing
enhance
neuron
survival,
ameliorate
cerebral
microenvironment,
restore
memory
functions.
This
study
reports
a
non‐invasive
strategy
overcome
physiological
barriers
against
drug
renders
profound
implications
treatment.
Язык: Английский