Biofilm, Год журнала: 2025, Номер 9, С. 100264 - 100264
Опубликована: Фев. 20, 2025
Biofilms are bacterial communities surrounded by a polymeric matrix that can form on implanted materials and biotic surfaces, resulting in chronic infection is recalcitrant to immune- antibiotic-mediated clearance. Therefore, biofilm infections present substantial clinical challenge, as treatment often involves additional surgical interventions remove the nidus, prolonged antimicrobial therapy clear residual bacteria, considerable risk of failure or recurrence. These factors, combined with progressive increases resistance, highlight need for alternative therapeutic strategies circumvent undue morbidity, mortality, resource strain healthcare system from infections. One promising option reprogramming dysfunctional immune responses elicited biofilm. Here, we review literature describing focus targets ripe translation. This represents complex dynamic context-dependent host-pathogen interactions differ across models, microenvironments, individuals. Nevertheless, consistencies among these variables exist, which could facilitate development immune-based future
Язык: Английский