Postoperative shunt failure following hemispherectomy in pediatric patients with pre-existing hydrocephalus DOI Creative Commons
Nikita Das, Akshay Sharma, Michael B. Mann

и другие.

Child s Nervous System, Год журнала: 2024, Номер 40(5), С. 1507 - 1514

Опубликована: Янв. 25, 2024

Abstract Objective The risk of hydrocephalus following hemispherectomy for drug resistant epilepsy (DRE) remains high. Patients with pre-existing pose a postoperative challenge, as maintaining existing shunt patency is necessary but lacks clearly defined strategy. This study examines the incidence and predictors failure in pediatric patients ventricular shunts. Methods We performed retrospective chart review at our center to identify diagnosed DRE who were treated prior their first surgery. Demographic perioperative data obtained including history, etiology, duration, surgical technique, outcomes. Univariate analysis was using Fisher’s exact test Pearson correlation, Bonferroni correction = 0.00625 0.01, respectively. Results Five nineteen (26.3%) identified ventriculoperitoneal shunting experienced malfunction. All 5 these underwent least 1 revision hemispherectomy, significant association between pre- post-hemispherectomy revisions. There no valve type, intraoperative alteration, external drain placement, revision, lateralization relative resection, complications, or aseptic meningitis. correlation number revisions age duration hemispherectomy. Conclusions Earlier surgery may portend subsequent need These findings guide neurosurgeons counseling shunts

Язык: Английский

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review DOI Creative Commons
Jinsong Zeng, Tingting Bao, Kailin Yang

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 13

Опубликована: Фев. 2, 2023

Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and oxidative stress play important roles in various complex mechanisms IS. In particular, early proinflammatory response resulting from overactivation resident microglia infiltration circulating monocytes macrophages brain after cerebral ischemia leads to secondary injury. Microglia are innate immune cells that constantly monitor microenvironment under normal conditions. Once occurs, activated produce dual effects neurotoxicity neuroprotection, balance two determines fate damaged neurons. The activation defined as classical (M1 type) or alternative (M2 type). M1 type secrete pro-inflammatory cytokines neurotoxic mediators exacerbate neuronal damage, while M2 promote a repairing anti-inflammatory response. Fine regulation M1/M2 microglial minimize damage maximize protection has therapeutic value. This review focuses on interaction between other involved IS phenotypic characteristics, mechanism natural plant components regulating IS, providing novel candidate drugs for drug development.

Язык: Английский

Процитировано

84
HDAC3 inhibitor (BRD3308) modulates microglial pyroptosis and neuroinflammation through PPARγ/NLRP3/GSDMD to improve neurological function after intraventricular hemorrhage in mice DOI
Yuanyou Li, Chang Liu, Guoqing Wang

и другие.

Neuropharmacology, Год журнала: 2023, Номер 237, С. 109633 - 109633

Опубликована: Июнь 15, 2023

Язык: Английский

Процитировано

16
Inflammatory Markers as Predictors of Shunt Dependency and Functional Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage DOI Creative Commons
Nina Rostgaard, Markus Harboe Olsen, Tenna Capion

и другие.

Biomedicines, Год журнала: 2023, Номер 11(4), С. 997 - 997

Опубликована: Март 23, 2023

The mechanisms underlying post-hemorrhagic hydrocephalus (PHH) development following subarachnoid hemorrhage (SAH) are not fully understood, which complicates informed clinical decisions regarding the duration of external ventricular drain (EVD) treatment and prevents prediction shunt-dependency in individual patient. aim this study was to identify potential inflammatory cerebrospinal fluid (CSF) biomarkers PHH and, thus, functional outcome patients with SAH. This a prospective observational designed evaluate markers CSF. In total, 31 Patients SAH who required an EVD between June 2019 September 2021 at Department Neurosurgery, Rigshospitalet, Copenhagen, Denmark, were included. CSF samples collected twice from each patient analyzed for 92 via proximity extension assay (PEA), prognostic ability investigated. 12 developed PHH, while 19 weaned their EVD. Their 6-month determined modified Rankin Scale. Of biomarkers, 79 identified samples. Seven (SCF, OPG, LAP TGFβ1, Flt3L, FGF19, CST5, CSF1) found be predictors shunt dependency, four (TNFα, CXCL5, CCL20, IL8) outcome. study, we promising that able predict (i) (ii) dependency patients. These may have employed as predictive could, such, applied clinic.

Язык: Английский

Процитировано

14
Cerebrospinal fluid markers of neuroinflammation and coagulation in severe cerebral edema and chronic hydrocephalus after subarachnoid hemorrhage: a prospective study DOI Creative Commons
Yuanjian Fang, Yibo Liu, Luxi Chen

и другие.

Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)

Опубликована: Сен. 27, 2024

Early severe cerebral edema and chronic hydrocephalus are the primary cause of poor prognosis in patients with subarachnoid hemorrhage (SAH). This study investigated role cerebrospinal fluid (CSF) inflammatory cytokines coagulation factors development SAH.

Язык: Английский

Процитировано

6
Choroid plexus CCL2‒CCR2 signaling orchestrates macrophage recruitment and cerebrospinal fluid hypersecretion in hydrocephalus DOI Creative Commons
Qiguang Wang, Fei Liu, Yue Li

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(10), С. 4544 - 4559

Опубликована: Июнь 26, 2024

The choroid plexus (ChP) serves as the principal origin of cerebrospinal fluid (CSF). CSF hypersecretion due to ChP inflammation has emerged an important pathogenesis hydrocephalus recently. Nevertheless, precise mechanisms and ensuing in remain ill-defined. In present study, we elucidate critical role macrophages inflammation. Specifically, identify chemokine CCL2, released by epithelial cells, recruits CCR2

Язык: Английский

Процитировано

5
NLRP3-dependent lipid droplet formation contributes to posthemorrhagic hydrocephalus by increasing the permeability of the blood–cerebrospinal fluid barrier in the choroid plexus DOI Creative Commons
Zhaoqi Zhang, Peiwen Guo, Liang Liang

и другие.

Experimental & Molecular Medicine, Год журнала: 2023, Номер 55(3), С. 574 - 586

Опубликована: Март 3, 2023

Abstract Hydrocephalus is a severe complication that can result from intracerebral hemorrhage, especially if this hemorrhage extends into the ventricles. Our previous study indicated NLRP3 inflammasome mediates cerebrospinal fluid hypersecretion in choroid plexus epithelium. However, pathogenesis of posthemorrhagic hydrocephalus remains unclear, and therapeutic strategies for prevention treatment are lacking. In study, an Nlrp3 −/− rat model with ventricular extension primary epithelial cell culture were used to investigate potential effects NLRP3-dependent lipid droplet formation its role hydrocephalus. The data NLRP3-mediated dysfunction blood–cerebrospinal barrier (B-CSFB) accelerated neurological deficits hydrocephalus, at least part, through droplets plexus; these interacted mitochondria increased release mitochondrial reactive oxygen species destroyed tight junctions after extension. This broadens current understanding relationship among NLRP3, B-CSFB provides new target Strategies protect may be effective approaches

Язык: Английский

Процитировано

11
Iron homeostasis and post-hemorrhagic hydrocephalus: a review DOI Creative Commons
Shelei Pan, Andrew T. Hale, Mackenzie Lemieux

и другие.

Frontiers in Neurology, Год журнала: 2024, Номер 14

Опубликована: Янв. 12, 2024

Iron physiology is regulated by a complex interplay of extracellular transport systems, coordinated transcriptional responses, and iron efflux mechanisms. Dysregulation metabolism can result in defects myelination, neurotransmitter synthesis, neuronal maturation. In neonates, germinal matrix-intraventricular hemorrhage (GMH-IVH) causes overload as blood breakdown the ventricles brain parenchyma which lead to post-hemorrhagic hydrocephalus (PHH). However, precise mechanisms GMH-IVH results PHH remain elusive. Understanding molecular determinants homeostasis developing may improved therapies. This manuscript reviews various roles has development, characterizes our understanding brain, describes potential cause injury. We also review novel preclinical treatments for IVH that specifically target iron. handling within central nervous system provide basis preventative, targeted iron-mediated pathogenesis PHH.

Язык: Английский

Процитировано

4
Lipocalin-2 inhibition alleviates neural injury by microglia ferroptosis suppression after experimental intracerebral hemorrhage in mice via enhancing ferritin light chain expression DOI
Xiaowei Fei,

Yanan Dou,

Yuefan Yang

и другие.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1870(7), С. 167435 - 167435

Опубликована: Июль 26, 2024

Язык: Английский

Процитировано

4
CSF hypersecretion versus impaired CSF absorption in posthemorrhagic hydrocephalus: a systematic review DOI
Shai David Ben-Shoshan, Sara Diana Lolansen, Tiit Mathiesen

и другие.

Acta Neurochirurgica, Год журнала: 2023, Номер 165(11), С. 3271 - 3287

Опубликована: Авг. 29, 2023

Язык: Английский

Процитировано

9
Shunt-Dependent Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage: Investigation of Prognostic Variables and Creation of a Stronger Predictive Model DOI Creative Commons
James T. McMahon, James G. Malcolm,

J DOUGLAS

и другие.

World Neurosurgery, Год журнала: 2025, Номер 195, С. 123659 - 123659

Опубликована: Янв. 24, 2025

Aneurysmal subarachnoid hemorrhage (aSAH) is frequently complicated by permanent shunt-dependent hydrocephalus, but it difficult to predict which patients are at highest risk. This study seeks identify novel variables associated with shunt dependency after aSAH and create a predictive algorithm that improves upon existing models. Retrospective case control design was used. Patients who presented external ventricular drain (EVD) placement were included. Those successfully weaned off their EVD compared those required placement. Demographic treatment data analyzed using univariate multivariable logistic regression. Receiver operating characteristic (ROC) used compare the proposed model's performance against ones (BNI, CHESS, SDASH). 100 included: 50 No Shunt Shunt. Advanced age, elevated modified Graeb score, intraventricular hemorrhage, increased clot thickness, acute CSF protein >110mg/dL prior wean attempt all found be significantly progression shunt-dependency (p = .0351, .0022, .0407, .0274, .0014, .0064, respectively). Multivariate regression demonstrated an area under curve of 0.7852 < .0001), outperforming other Our suggests score on initial CT high levels important prognostic indicators for development aSAH. Integrating these findings into clinical practice may aid in earlier more targeted decision-making.

Язык: Английский

Процитировано

0