Nanomedicine Nanotechnology Biology and Medicine, Год журнала: 2024, Номер 61, С. 102763 - 102763
Опубликована: Июнь 17, 2024
Язык: Английский
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 12
Опубликована: Янв. 6, 2025
Recent advancements in the mechanistic comprehension of vascular biology have concentrated on METTL3-mediated N6-methyladenosine modification RNA, which modulates a spectrum RNA functionalities with precision. Despite extensive investigations into roles and mechanisms METTL3 within biology, holistic review elucidating their interconnections remains absent. This analysis endeavors to meticulously scrutinize involvement both physiological pathological paradigms biology. The findings this indicate that is indispensable for development functionality, predominantly through its regulatory influence pericytes, endothelial cells, smooth muscle hematopoietic stem cells. Conversely, aberrant activity implicated as risk factor, diagnostic biomarker, therapeutic target pathologies. comprehensive offers an exhaustive synthesis METTL3's role addressing existing knowledge gaps serving essential reference future research potential clinical applications.
Язык: Английский
Процитировано
1
International Journal of Biological Sciences, Год журнала: 2023, Номер 20(2), С. 433 - 445
Опубликована: Дек. 5, 2023
METTL3, an RNA methyltransferase enzyme, exerts therapeutic effects on various cardiovascular diseases.Myocardial ischemia-reperfusion injury (MIRI) and subsequently cardiac fibrosis is linked to acute cardiomyocyte death or dysfunction induced by mitochondrial damage, particularly fission.Our research aims elucidate the potential mechanisms underlying actions of METTL3 in MIRI, with focus fission.When compared Mettl3 flox mice subjected knockout (Mettl3 Cko ) have reduced infarct size, decreased serum levels myocardial injury-related factors, limited fibrosis, preserved ultrastructure contractile/relaxation capacity.The cardioprotective were associated inflammatory responses, neutrophil infiltration, suppression death.Through signaling pathway validation experiments assays cultured HL-1 cardiomyocytes exposed hypoxia/reoxygenation, we confirmed that deficiency interfere DNA-PKcs phosphorylation, thereby blocking downstream activation Fis1 preventing pathological fission.In conclusion, this study confirms inhibition can alleviate inflammation prevent under reperfusion conditions disrupting DNA-PKcs/Fis1-dependent fission, ultimately improving function.These findings suggest new approaches for clinical intervention patients MIRI.
Язык: Английский
Процитировано
11
Molecular Biomedicine, Год журнала: 2024, Номер 5(1)
Опубликована: Авг. 19, 2024
Abstract Transcription, RNA splicing, translation, and post-translational protein modification are fundamental processes of gene expression. Epigenetic modifications, such as DNA methylation, play a crucial role in regulating The methyltransferase-like (METTL) family, constituent the 7-β-strand (7BS) methyltransferase subfamily, is broadly distributed across cell nucleus, cytoplasm, mitochondria. Members METTL through their S-adenosyl methionine (SAM) binding domain, can transfer methyl groups to DNA, RNA, or proteins, thereby impacting replication, transcription, mRNA participate maintenance normal function promote disease development. This review primarily examines involvement family differentiation, mitochondrial function, its association with tumor formation, nervous system, cardiovascular diseases. Notably, intricately linked cellular particularly regulation translation factors. represent important molecules development associated patient immunity tolerance radiotherapy chemotherapy. Moreover, future research directions could include drugs antibodies targeting structural domains, utilizing nanomaterials carry miRNA corresponding mRNA. Additionally, precise mechanisms underlying interactions between factors remain be clarified.
Язык: Английский
Процитировано
4
Virus Genes, Год журнала: 2025, Номер unknown
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
0
Current Issues in Molecular Biology, Год журнала: 2023, Номер 45(11), С. 8780 - 8815
Опубликована: Ноя. 1, 2023
A strong relationship exists between immune dysfunction and cardiovascular disease. Immune dysregulation can promote the development of diseases as well exacerbate their course. The disorders may occur due to presence primary defects (currently known inborn errors immunity) more common secondary deficiencies. Secondary deficiencies be caused by certain chronic conditions (such diabetes, kidney disease, obesity, autoimmune diseases, or cancer), nutritional (including both lack nutrients bioactive non-nutrient compounds), medical treatments addictive substances. This article unravels molecular linkage aforementioned system atherosclerosis.
Язык: Английский
Процитировано
6
Pharmacological Research, Год журнала: 2024, Номер 207, С. 107305 - 107305
Опубликована: Июль 11, 2024
Cardiomyopathy (CM) represents a heterogeneous group of diseases primarily affecting cardiac structure and function, with genetic epigenetic dysregulation playing pivotal role in its pathogenesis. Emerging evidence from the burgeoning field epitranscriptomics has brought to light significant impact various RNA modifications, notably N6-methyladenosine (m6A), 5-methylcytosine (m5C), N7-methylguanosine (m7G), N1-methyladenosine (m1A), 2′-O-methylation (Nm), 6,2′-O-dimethyladenosine (m6Am), on cardiomyocyte function broader processes vascular remodelling. These modifications have been shown influence key pathological mechanisms including mitochondrial dysfunction, oxidative stress, apoptosis, inflammation, immune response, myocardial fibrosis. Importantly, aberrations methylation machinery observed human CM cases animal models, highlighting critical methylating enzymes their potential as therapeutic targets or biomarkers for CM. This review underscores necessity deeper understanding context CM, illuminate novel avenues diagnostic tools, thereby addressing gap current management strategies this complex disease.
Язык: Английский
Процитировано
2
Nanomedicine Nanotechnology Biology and Medicine, Год журнала: 2024, Номер 61, С. 102763 - 102763
Опубликована: Июнь 17, 2024
Язык: Английский
Процитировано
1