Exploration of Molecular Mechanisms and Potential Traditional Chinese Medicine Intervention in Acute Liver Injury
Natural Product Communications,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 1, 2025
Objective
This
study
aimed
to
explore
the
potential
targets
and
molecular
mechanisms
underlying
progression
of
acute
liver
injury,
as
well
predict
traditional
Chinese
medicines
associated
with
key
targets.
Methods
Differentially
expressed
genes
(DEGs)
injury
were
first
screened.
Then
immune
infiltration
analysis
was
performed
using
CIBERSORT
algorithm,
followed
by
Weighted
Gene
Co-Expression
Network
Analysis
(WGCNA)
analysis.
Subsequently,
Ontology
(GO)
Kyoto
Encyclopedia
Genomes
(KEGG)
analyses
overlapping
between
DEG
WGCNA
DAVID
database.
The
main
active
components
predicted
determined
through
network
pharmacology
In
vitro
experiment
observe
effects
different
concentrations
quercetin
on
inflammatory
response
LPS-induced
J774A.1
macrophages.
Results
results
showed
elevated
M1
macrophages
activated
dendritic
cells
in
injury.
A
total
40
DEGs
obtained,
which
significantly
enriched
four
pathways,
including
Toll-like
receptor
signaling
pathway
(
P
<
.05).
Furthermore,
eight
identified,
pharmacological
revealed
their
ingredient.
experimental
that
reduced
mRNA
levels
IL-6,
TNF-α,
IL-1β,
NF-κB
protein
IL-6
TNF-α
Additionally,
inhibited
release
NO
Conclusion
present
provides
further
evidence
potentially
exert
pro-inflammatory
via
toll-like
pathways.
Notably,
demonstrates
inhibitory
properties
this
process,
its
mechanism
action
may
be
intricately
linked
TLR4-NF-κB
pathway.
Язык: Английский
Identifying Shared Molecular Landscape between Uterine Fibroids and Recurrent Implantation Failure: An Integrated Bioinformatics Study
Heliyon,
Год журнала:
2025,
Номер
unknown, С. e43006 - e43006
Опубликована: Фев. 1, 2025
Язык: Английский
Computer-Aided Drug Design in Research on Chinese Materia Medica: Methods, Applications, Advantages, and Challenges
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 315 - 315
Опубликована: Март 1, 2025
Chinese
materia
medica
(CMM)
refers
to
the
medicinal
substances
used
in
traditional
medicine.
In
recent
years,
CMM
has
become
globally
prevalent,
and
scientific
research
on
increasingly
garnered
attention.
Computer-aided
drug
design
(CADD)
been
employed
Western
medicine
for
many
contributing
significantly
its
progress.
However,
role
of
CADD
not
systematically
reviewed.
This
review
briefly
introduces
methods
from
perspectives
computational
chemistry
(including
quantum
chemistry,
molecular
mechanics,
mechanics/molecular
mechanics)
informatics
cheminformatics,
bioinformatics,
data
mining).
Then,
it
provides
an
exhaustive
discussion
applications
these
through
rich
cases.
Finally,
outlines
advantages
challenges
research.
conclusion,
despite
current
challenges,
still
offers
unique
over
experiments.
With
development
industry
computer
science,
especially
driven
by
artificial
intelligence,
is
poised
play
pivotal
advancing
Язык: Английский
Network pharmacological approach combined with weighted gene co-expression network analysis identifies CDKN2A as the keg target of Changweiqing against colorectal cancer
Hereditas,
Год журнала:
2025,
Номер
162(1)
Опубликована: Март 10, 2025
Язык: Английский
Role of traditional Chinese medicine in supporting liver transplantation outcomes
World Journal of Transplantation,
Год журнала:
2025,
Номер
15(3)
Опубликована: Апрель 18, 2025
A
recent
article
published
by
Virches
et
al
highlights
the
psychological
and
physical
challenges
faced
caregivers
emphasizes
transformative
role
of
liver
transplantation.
Traditional
Chinese
medicine
(TCM)
may
serve
as
a
complementary
approach
in
this
context,
offering
unique
benefits
such
immunomodulation,
neuropsychological
regulation,
hepatoprotection,
quality-of-life
enhancement.
TCM’s
holistic
principles
individualized
treatments
can
improve
post-transplant
recovery,
mitigate
caregiver
stress,
address
long-term
health
risks
like
metabolic
dysfunction.
Further
research
into
integrating
TCM
with
conventional
could
unlock
new
avenues
for
improving
patient
outcomes
well-being
transplantation
settings.
Язык: Английский
Genome Sequencing Identifies 13 Novel Candidate Risk Genes for Autism Spectrum Disorder in a Qatari Cohort
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11551 - 11551
Опубликована: Окт. 27, 2024
Autism
spectrum
disorder
(ASD)
is
a
neurodevelopmental
condition
characterized
by
deficits
in
social
communication,
restricted
interests,
and
repetitive
behaviors.
Despite
considerable
research
efforts,
the
genetic
complexity
of
ASD
remains
poorly
understood,
complicating
diagnosis
treatment,
especially
Arab
population,
with
its
diversity
linked
to
migration,
tribal
structures,
high
consanguinity.
To
address
scarcity
data
Middle
East,
we
conducted
genome
sequencing
(GS)
on
50
subjects
their
unaffected
parents.
Our
analysis
revealed
37
single-nucleotide
variants
from
36
candidate
genes
over
200
CGG
repeats
FMR1
gene
one
subject.
The
identified
were
classified
as
uncertain,
likely
pathogenic,
or
pathogenic
based
in-silico
algorithms
ACMG
criteria.
Notably,
52%
homozygous,
indicating
recessive
architecture
this
population.
This
finding
underscores
significant
impact
consanguinity
within
Qatari
which
could
be
utilized
counseling/screening
program
Qatar.
We
also
discovered
single
nucleotide
13
novel
not
previously
associated
ASD:
ARSF,
BAHD1,
CHST7,
CUL2,
FRMPD3,
KCNC4,
LFNG,
RGS4,
RNF133,
SCRN2,
SLC12A8,
USP24,
ZNF746.
investigation
categorized
into
seven
groups,
highlighting
roles
cognitive
development,
including
ubiquitin
pathway,
transcription
factors,
solute
carriers,
kinases,
glutamate
receptors,
chromatin
remodelers,
ion
channels.
Язык: Английский
Effects of Extremely Low-Frequency Electromagnetic Field Treatment on ASD Symptoms in Children: A Pilot Study
Brain Sciences,
Год журнала:
2024,
Номер
14(12), С. 1293 - 1293
Опубликована: Дек. 22, 2024
Background/Objectives:
Autism
Spectrum
Disorder
(ASD)
are
neurodevelopmental
disorders
marked
by
challenges
in
social
interaction,
communication,
and
repetitive
behaviors.
People
with
ASD
may
exhibit
behaviors,
unique
ways
of
learning,
different
interacting
the
world.
The
term
“spectrum”
reflects
wide
variability
how
manifests
individuals,
including
differences
abilities,
symptoms,
support
needs,
conditions
characterized
difficulties
interactions,
restricted
interests,
Inflammation
plays
a
crucial
role
pathophysiology,
increased
pro-inflammatory
cytokines
cerebrospinal
fluid.
Previous
studies
transcranial
magnetic
stimulation
have
shown
promising
results,
suggesting
nervous
system
susceptibility
to
electromagnetic
fields,
evidence
indicating
that
extremely
low-frequency
field
(ELF-EMF)
treatment
modulate
inflammatory
responses
through
multiple
pathways,
reduction
like
IL-6
TNF-α,
enhancement
anti-inflammatory
mediators.
Methods:
This
pilot
study
included
20
children
(ages
2–13)
confirmed
diagnosis
ASD.
A
15-week
protocol
involved
ELF-EMF
treatments
using
SEQEX
device,
specific
day
night
programs.
Assessment
was
conducted
standardized
pre-
post-treatment
tests:
Achenbach
Child
Behavior
Checklist,
Peabody
Picture
Vocabulary
Test-4,
Expressive
One
Word
Conner’s
3GI.
Results:
Statistically
significant
improvements
were
observed
receptive
language
(PPVT-4:
from
74.07
90.40,
p
=
0.002)
expressive
(EOWPVT-4:
84.17
90.50,
0.041).
Notable
reductions,
statistical
significance,
found
externalizing
problems
across
both
age
groups
(1.5–5
years:
0.028;
6–18
0.027),
particular
improvement
attention
behavioral
problems.
results
over
short
period
15
weeks,
therefore
excluding
possibility
coincidental
age-related
gains,
would
typically
occur
during
normal
developmental
timeframe.
Parent
evaluations
showed
particularly
1.5–5
years
group
(p
0.046).
Conclusions:
demonstrated
high
safety
profile
efficacy
mitigating
ASD-related
symptoms.
suggest
direct
effects
on
central
autonomic
systems
indirect
response
modulation.
Further
needed
confirm
these
broader
demographics
randomized
control
designs.
Язык: Английский