Repurposing oxiconazole to inhibit STING trafficking via OSBP and alleviate autoimmune pathology in Trex1 mice DOI
Hui Luo,

Yijing Cai,

Huichun Shi

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 157, С. 114742 - 114742

Опубликована: Май 3, 2025

Язык: Английский

Unraveling the cGAS-STING pathway in Alzheimer’s disease: A new Frontier in neuroinflammation and therapeutic strategies DOI
Arshdeep Kaur, Khadga Raj Aran

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Targeting microglia-Th17 feed-forward loop to suppress autoimmune neuroinflammation DOI Creative Commons
Jun Xiao, Zihan Meng, Yao Lu

и другие.

Journal of Neuroinflammation, Год журнала: 2025, Номер 22(1)

Опубликована: Апрель 24, 2025

Microglia and Th17 cells are the major immunopathogenic in multiple sclerosis its animal model of immune aspects, experimental autoimmune encephalomyelitis (EAE). While studies have highlighted distinct roles microglia EAE, it remains unclear whether microglia, as potential professional antigen-presenting cells, activate stabilize effector program EAE-pathogenic vivo; if so, could turn reinforce active state microglia. Our data demonstrate an array mouse models, including active/passive-EAE transgenic mice, a microglia-Th17 feed-forward activation loop drives EAE disease progression through mechanism dependent on both MHC-II, proinflammatory cytokines, inflammatory chemokines well STING→NF-κB pathway cytokines produced by pathogenic cells. We also captured identified molecular properties loop, which two-cell entities microglia-Th17, proved them functional units antigen presentation bi-directional between two cell types. Moreover, ACT001, orphan drug to treat glioblastoma, disrupts this inhibiting thereby alleviating EAE. These findings emphasize importance interactions activations neuroinflammation, provide rationale for further investigation ACT001 therapeutic option diseases driven similar mechanisms.

Язык: Английский

Процитировано

0
Cascade-Targeting Hydrogel Microspheres with Biomimetic Nanoparticles Enable Multifaceted Anti-Inflammatory and Antioxidant Defense for Osteoarthritis Management DOI
Shengli Ma, Yuqiao Sheng, Chaoyang Zhang

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Mitochondrial connection to Alzheimer's disease and heart failure DOI Creative Commons

Anupriya Sinha,

Natasha Jaiswal, Pooja Jadiya

и другие.

Current Opinion in Physiology, Год журнала: 2025, Номер unknown, С. 100830 - 100830

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Repurposing oxiconazole to inhibit STING trafficking via OSBP and alleviate autoimmune pathology in Trex1 mice DOI
Hui Luo,

Yijing Cai,

Huichun Shi

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 157, С. 114742 - 114742

Опубликована: Май 3, 2025

Язык: Английский

Процитировано

0