The protective effects of Araucaria angustifolia (Bertol.) on neurodegeneration induced by LPS and kynurenine exposure in BV-2 microglial cells DOI
Ana Paula Vargas Visentin, Júlia Maiara dos Santos, Anne Pereira

и другие.

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Май 30, 2025

Язык: Английский

Netrin-3 enhances recovery and reduces inflammation following spinal cord injury via suppressing NLRP1 inflammasome activation DOI
Zhe Li, Xinghua Song,

Jialai Song

и другие.

Neuropeptides, Год журнала: 2025, Номер unknown, С. 102521 - 102521

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Key genes and pathways in asparagine metabolism in Alzheimer’s Disease: a bioinformatics approach DOI Creative Commons
Xiaoqian Lan,

Guangli Feng,

Qing Li

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

Abstract Background Asparagine (Asn) metabolism is essential for maintaining cellular homeostasis and supporting neuronal energy demands. Recent studies have suggested its dysregulation may contribute to Alzheimer’s disease (AD) pathogenesis; however, the specific genes regulatory mechanisms involved remain incompletely understood. Methods Four publicly available microarray datasets (GSE5281, GSE29378, GSE36980, GSE138260) were utilized investigate with differential expression between control AD samples. metabolism-related (AMGs) retrieved from GeneCards database, their intersection DEGs yielded candidate asparagine differentially expressed (AMG-DEGs). Functional enrichment analysis (Gene Set Enrichment Analysis, Gene Ontology Kyoto Encyclopedia of Genes Genomes), protein–protein interaction (PPI) network analysis, centrality scoring identified hub genes. Regulatory investigated through construction competing endogenous RNA transcription factor networks. Potential therapeutic compounds predicted via drug–gene evaluated using molecular docking simulations. Results Thirty-nine AMG-DEGs found be enriched in neurodevelopmental, synaptic transmission, inflammatory signaling pathways. PPI screening revealed seven ( HPRT1 , GAD2 TUBB3 GFAP CD44 CCL2 NFKBIA ). highlighted miRNAs, long non-coding RNAs, factors modulation. Drug Bathocuproine disulfonate, DL-Mevalonic acid, Phenethyl isothiocyanate as promising strong binding affinities proteins. Conclusion This study comprehensively maps reveals a set elements potentially progression. The provide foundation further experimental validation development novel metabolism-targeted strategies treatment.

Язык: Английский

Процитировано

0
Metabolomics and network pharmacology based study of the potential of Brassica campestris L. extract BREE-Ea for the treatment of Alzheimer's disease DOI
Jing Miao, Yan Huang, Yi Qi

и другие.

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Alzheimer's disease (AD) is a severe neurodegenerative disorder causing memory loss, cognitive decline, and behavioral changes.

Язык: Английский

Процитировано

0
The protective effects of Araucaria angustifolia (Bertol.) on neurodegeneration induced by LPS and kynurenine exposure in BV-2 microglial cells DOI
Ana Paula Vargas Visentin, Júlia Maiara dos Santos, Anne Pereira

и другие.

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Май 30, 2025

Язык: Английский

Процитировано

0