CSF biomarkers are differentially linked to brain areas high and low in noradrenaline, dopamine and serotonin across the Alzheimer’s disease spectrum DOI Creative Commons
Lena Haag, Elisa Lancini, Renat Yakupov

и другие.

Brain Communications, Год журнала: 2024, Номер 7(1)

Опубликована: Дек. 24, 2024

Abstract Neurotransmitter systems of noradrenaline, dopamine, serotonin and acetylcholine are implicated in cognitive functions such as memory, learning attention known to be altered neurodegenerative diseases like Alzheimer’s disease. Specific brain structures involved these systems, e.g. the locus coeruleus, main source noradrenaline cortex, fact affected earliest by disease tau pathology. Preserved volumetric neurotransmitter specific areas could therefore an important neural resource for reserve aging. The aim this study was determine whether volumes high receptors relatively preserved individuals with lower levels Based on Human Protein Atlas receptor distribution, we distinguished between ‘areas low’ assessed associations atrophy those CSF amyloid-ß 42/40, phosphorylated protein function across healthy controls (n = 122), subjective decline 156), mild impairment or dementia 126) using structural equation modelling. pathology markers were inversely correlated showed a stronger association severity, suggesting distinguishable interrelatedness biomarkers depending stage dementia. Across groups, amyloid linked well low densities, while did not show any significant link area neurotransmitters. Within severity more only noradrenaline’, whereas dopamine higher density possibly indicating compensatory mechanisms. Furthermore, selective decrease memory related executive language capacity function. In summary, our analyses highlight benefits investigating disease-relevant factors multivariate multigroup approach. Assessing dependencies different stages revealed links pathologies, particular modulated serotonin.

Язык: Английский

Plasma tryptophan levels are linked to hippocampal integrity and cognitive function in individuals with mild cognitive impairment DOI
Ali Azargoonjahromi

Brain Imaging and Behavior, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Язык: Английский

Процитировано

0
[18F]Mefway: Imaging Serotonin 5HT1A Receptors in Human Postmortem Alzheimer’s and Parkinson’s Disease Anterior Cingulate. Potential Applications to Human Positron Emission Tomography Studies DOI Creative Commons

Noresa L. Gonzaga,

Fariha Karim,

Christopher Liang

и другие.

Biomolecules, Год журнала: 2025, Номер 15(4), С. 592 - 592

Опубликована: Апрель 16, 2025

Serotonin 5HT1A receptors may be affected in neurodegeneration, such as Alzheimer’s disease (AD) and Parkinson’s (PD). Using the selective receptor positron emission tomography (PET) imaging agent, [18F]mefway, autoradiographic studies from postmortem human brains of AD, PD, cognitively normal (CN) subjects were carried out. Levels [18F]mefway binding compared with monoamine oxidase A (MAO-A) measured using [18F]FAZIN3 dopamine D2/D3 [18F]fallypride same subjects. Autoradiograms brain sections anterior cingulate corpus callosum CN, AD (n = 6 each group) analyzed. Significant increased was found (+30%) PD (+11%) to CN brains. This increase positively correlated binding, suggesting greater availability when MAO-A levels are higher. Differences three groups not significant. Our results support finding that is elevated cortex negatively MAO-A. upregulation potentially a response lower serotonin due activity this region or other neuroinflammatory changes. Thus, potential target for diagnostic therapeutic approaches PD.

Язык: Английский

Процитировано

0
CSF biomarkers are differentially linked to brain areas high and low in noradrenaline, dopamine and serotonin across the Alzheimer’s disease spectrum DOI Creative Commons
Lena Haag, Elisa Lancini, Renat Yakupov

и другие.

Brain Communications, Год журнала: 2024, Номер 7(1)

Опубликована: Дек. 24, 2024

Abstract Neurotransmitter systems of noradrenaline, dopamine, serotonin and acetylcholine are implicated in cognitive functions such as memory, learning attention known to be altered neurodegenerative diseases like Alzheimer’s disease. Specific brain structures involved these systems, e.g. the locus coeruleus, main source noradrenaline cortex, fact affected earliest by disease tau pathology. Preserved volumetric neurotransmitter specific areas could therefore an important neural resource for reserve aging. The aim this study was determine whether volumes high receptors relatively preserved individuals with lower levels Based on Human Protein Atlas receptor distribution, we distinguished between ‘areas low’ assessed associations atrophy those CSF amyloid-ß 42/40, phosphorylated protein function across healthy controls (n = 122), subjective decline 156), mild impairment or dementia 126) using structural equation modelling. pathology markers were inversely correlated showed a stronger association severity, suggesting distinguishable interrelatedness biomarkers depending stage dementia. Across groups, amyloid linked well low densities, while did not show any significant link area neurotransmitters. Within severity more only noradrenaline’, whereas dopamine higher density possibly indicating compensatory mechanisms. Furthermore, selective decrease memory related executive language capacity function. In summary, our analyses highlight benefits investigating disease-relevant factors multivariate multigroup approach. Assessing dependencies different stages revealed links pathologies, particular modulated serotonin.

Язык: Английский

Процитировано

0