Therapeutic potential of AMPK signaling targeting in lung cancer: Advances, challenges and future prospects

Life Sciences, Год журнала: 2021, Номер 278, С. 119649 - 119649

Опубликована: Май 24, 2021

Язык: Английский

---

The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?

Frontiers in Oncology, Год журнала: 2021, Номер 11

Опубликована: Ноя. 4, 2021

The RNA-binding motif (RBM) proteins are a class of named, containing RNA-recognition motifs (RRMs), domains, and ribonucleoprotein motifs. RBM involved in RNA metabolism, including splicing, transport, translation, stability. Many studies have found that aberrant expression dysregulated function family members closely related to the occurrence development cancers. This review summarizes role genes cancers, their roles cancer cell proliferation, migration, apoptosis. It is essential understand mechanisms these tumorigenesis development, identify new therapeutic targets prognostic markers.

Язык: Английский

---

METTL3 modulates m6A modification of CDC25B and promotes head and neck squamous cell carcinoma malignant progression

Experimental Hematology and Oncology, Год журнала: 2022, Номер 11(1)

Опубликована: Март 14, 2022

Abstract Background N6-methyladenosine (m6A) RNA methylation and its methyltransferase METTL3 have been widely reported to be involved in different cancers by regulating metabolism function. Here, we aimed explore the biological function clinical significance of m6A modification head neck squamous cell carcinoma (HNSCC). Methods The prognostic value expression was evaluated using tissue microarray immunohistochemical staining analyses a human HNSCC cohort. role mechanism tumour growth, metastasis angiogenesis were determined vitro vivo. Results M6A levels expressions tissues significantly increased compared with paired adjacent tissues. Meanwhile, an independent risk factor for prognosis patients. Moreover, overexpression promoted proliferation, migration, invasion, angiogenesis, while knockdown had opposite effect vivo vitro. Mechanistically, enhanced CDC25B mRNA, which maintained stability upregulated expression, thereby activating G2/M phase cycle leading malignant progression. Conclusions may potential biomarker therapeutic target HNSCC.

Язык: Английский

---

RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 191, С. 114569 - 114569

Опубликована: Окт. 14, 2022

Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-transcriptional events. Alterations in the proteins that act post-transcriptionally can affect cellular signaling homeostasis. RNA binding (RBPs) are a family specifically bind to RNAs involved regulation important processes such as cell differentiation metabolism. Deregulation RNA-RBP interactions any changes RBP or function lead various diseases including cancer. In cancer cells, RBPs play an role regulating tumor suppressors oncoproteins cell-signaling pathways. Several HuR, AUF1, RBM38, LIN28, RBM24, tristetrapolin Musashi critical roles types cancers their aberrant cells makes them attractive therapeutic target for treatment. this review we provide overview i). progression mechanism action ii). RBPs, breast DNA damage response iii). explore with emphasis on HuR therapy.

Язык: Английский

---

3′UTR heterogeneity and cancer progression

Trends in Cell Biology, Год журнала: 2022, Номер 33(7), С. 568 - 582

Опубликована: Ноя. 11, 2022

Язык: Английский

---