International Journal of Oncology,
Год журнала:
2024,
Номер
64(6)
Опубликована: Май 9, 2024
Hepatocellular
carcinoma
(HCC),
one
of
the
leading
causes
cancer‑related
mortality
worldwide,
is
challenging
to
identify
in
its
early
stages
and
prone
metastasis,
prognosis
patients
with
this
disease
poor.
Treatment
options
for
HCC
are
limited,
even
radical
treatments
being
associated
a
risk
recurrence
or
transformation
short
term.
Furthermore,
multi‑tyrosine
kinase
inhibitors
approved
first‑line
therapy
have
marked
drawbacks,
including
drug
resistance
side
effects.
The
rise
breakthrough
immune
checkpoint
(ICIs)
provided
novel
direction
immunotherapy
but
these
drawback
low
response
rates.
Since
avoiding
apoptosis
universal
feature
cancer,
induction
non‑apoptotic
regulatory
cell
death
(NARCD)
strategy
immunotherapy.
At
present,
NARCD
pathways,
ferroptosis,
pyroptosis
necroptosis,
potential
forms
immunogenic
death,
which
synergistic
effects
antitumor
immunity,
transforming
'cold'
tumors
into
'hot'
exerting
Therefore,
pathways
may
be
targeted
as
treatment
HCC.
In
present
review,
roles
necroptosis
immunity
discussed,
relevant
targets
signaling
current
status
combined
ICIs
summarized.
prospects
targeting
also
considered.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 13, 2024
Abstract
Bladder
cancer
(BLCA)
is
the
most
frequent
malignant
tumor
of
genitourinary
system.
Postoperative
chemotherapy
drug
perfusion
and
are
important
means
for
treatment
BLCA.
However,
once
resistance
occurs,
BLCA
develops
rapidly
after
recurrence.
cells
rely
on
unique
metabolic
rewriting
to
maintain
their
growth
proliferation.
relationship
between
pattern
changes
in
unclear.
At
present,
this
problem
lacks
systematic
research.
In
our
research,
we
identified
analyzed
resistance-
metabolism-related
differentially
expressed
genes
(RM-DEGs)
based
RNA
sequencing
a
gemcitabine-resistant
cell
line
metabolic-related
(MRGs).
Then,
established
model
(RM-RM)
through
regression
analysis
predict
overall
survival
We
also
confirmed
that
RM-RM
had
significant
correlation
with
metabolism,
gene
mutations,
microenvironment,
adverse
reactions.
Patients
high
risk
score
(RM-RS)
showed
more
active
lipid
synthesis
than
those
low
RM-RS.
Further
vitro
vivo
studies
were
implemented
using
Fatty
Acid
Synthase
(FASN),
representative
gene,
which
promotes
gemcitabine
resistance,
its
inhibitor
(TVB-3166)
can
reverse
effect.
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 12, 2024
Lipids,
the
primary
constituents
of
cell
membrane,
play
essential
roles
in
nearly
all
cellular
functions,
such
as
cell-cell
recognition,
signaling
transduction,
and
energy
provision.
Lipid
metabolism
is
necessary
for
maintenance
life
since
it
regulates
balance
between
processes
synthesis
breakdown.
Increasing
evidence
suggests
that
cancer
cells
exhibit
abnormal
lipid
metabolism,
significantly
affecting
their
malignant
characteristics,
including
self-renewal,
differentiation,
invasion,
metastasis,
drug
sensitivity
resistance.
Prominent
oncogenic
pathways
modulate
metabolic
gene
expression
elevate
enzyme
activity
include
phosphoinositide
3-kinase
(PI3K)/AKT,
MAPK,
NF-kB,
Wnt,
Notch,
Hippo
pathway.
Conversely,
when
are
not
regulated,
they
can
lead
to
malfunctions
signal
transduction
pathways.
This,
turn,
enables
uncontrolled
growth
by
providing
energy,
building
blocks,
redox
potentials.
Therefore,
targeting
metabolism-associated
could
be
an
effective
therapeutic
approach
decrease
incidence
promote
survival.
This
review
sheds
light
on
interactions
reprogramming
cancer.
Exploring
a
target
provide
promising
creating
anticancer
treatments
identifying
inhibitors.
Additionally,
we
have
also
provided
overview
drugs
this
review.
Journal of Hepatocellular Carcinoma,
Год журнала:
2024,
Номер
Volume 11, С. 327 - 346
Опубликована: Фев. 1, 2024
Abstract:
Hepatocellular
carcinoma
(HCC)
stands
as
a
severe
malignant
tumor
with
profound
impact
on
overall
health,
often
accompanied
by
an
unfavorable
prognosis.
Despite
some
advancements
in
the
diagnosis
and
treatment
of
this
disease,
improving
prognosis
HCC
remains
formidable
challenge.
It
is
noteworthy
that
lipid
metabolism
plays
pivotal
role
onset,
development,
progression
cells.
Existing
research
indicates
potential
application
targeting
HCC.
This
review
aims
to
thoroughly
explore
alterations
HCC,
offering
detailed
account
advantages
associated
innovative
therapeutic
strategies
metabolism.
Targeting
holds
promise
for
potentially
enhancing
Keywords:
cholesterol,
fatty
acid,
hepatocellular
carcinoma,
uptake,
catabolism,
synthesis
Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(8)
Опубликована: Апрель 1, 2024
Abstract
Management
of
hepatocellular
carcinoma
(HCC)
remains
challenging
due
to
population
growth,
frequent
recurrence
and
drug
resistance.
Targeting
genes
involved
with
the
ferroptosis
is
a
promising
alternative
treatment
strategy
for
HCC.
The
present
study
aimed
investigate
effect
dihydroartemisinin
(DHA)
against
HCC
explore
underlying
mechanisms.
effects
DHA
on
induction
were
investigated
measurement
malondialdehyde
concentrations,
oxidised
C11
BODIPY
581/591
staining,
as
well
subcutaneous
xenograft
experiments.
Activated
transcription
factor
4
(ATF4)
solute
carrier
family
7
member
11
(SLC7A11
or
xCT)
overexpressed
lentiviruses
verify
target
DHA.
Here,
we
confirmed
anticancer
in
inducing
related
ATF4.
High
expression
ATF4
worse
clinicopathological
prognosis
Mechanistically,
inhibited
ATF4,
thereby
promoting
lipid
peroxidation
cells.
Overexpression
rescued
DHA‐induced
ferroptosis.
Moreover,
could
directly
bound
SLC7A11
promoter
increase
its
transcription.
In
addition,
enhances
chemosensitivity
sorafenib
vivo
vitro.
These
findings
confirm
that
induces
via
inhibiting
ATF4‐xCT
pathway,
providing
new
options
International Journal of Oncology,
Год журнала:
2024,
Номер
64(6)
Опубликована: Май 9, 2024
Hepatocellular
carcinoma
(HCC),
one
of
the
leading
causes
cancer‑related
mortality
worldwide,
is
challenging
to
identify
in
its
early
stages
and
prone
metastasis,
prognosis
patients
with
this
disease
poor.
Treatment
options
for
HCC
are
limited,
even
radical
treatments
being
associated
a
risk
recurrence
or
transformation
short
term.
Furthermore,
multi‑tyrosine
kinase
inhibitors
approved
first‑line
therapy
have
marked
drawbacks,
including
drug
resistance
side
effects.
The
rise
breakthrough
immune
checkpoint
(ICIs)
provided
novel
direction
immunotherapy
but
these
drawback
low
response
rates.
Since
avoiding
apoptosis
universal
feature
cancer,
induction
non‑apoptotic
regulatory
cell
death
(NARCD)
strategy
immunotherapy.
At
present,
NARCD
pathways,
ferroptosis,
pyroptosis
necroptosis,
potential
forms
immunogenic
death,
which
synergistic
effects
antitumor
immunity,
transforming
'cold'
tumors
into
'hot'
exerting
Therefore,
pathways
may
be
targeted
as
treatment
HCC.
In
present
review,
roles
necroptosis
immunity
discussed,
relevant
targets
signaling
current
status
combined
ICIs
summarized.
prospects
targeting
also
considered.
