Nature Reviews Genetics, Год журнала: 2023, Номер 25(1), С. 8 - 25
Опубликована: Авг. 24, 2023
Язык: Английский
Процитировано
132Imputation accuracy across global human populations
The American Journal of Human Genetics, Год журнала: 2024, Номер 111(5), С. 979 - 989
Опубликована: Апрель 10, 2024
Язык: Английский
Процитировано
8Protective alleles and precision healthcare in crewed spaceflight
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Июль 22, 2024
Abstract Common and rare alleles are now being annotated across millions of human genomes, omics technologies increasingly used to develop health treatment recommendations. However, these have not yet been systematically characterized relative aerospace medicine. Here, we review published naturally found in cohorts that a likely protective effect, which is linked decreased cancer risk improved bone, muscular, cardiovascular health. Although some technical ethical challenges remain, research into mechanisms could translate nutrition, exercise, recommendations for crew members during deep space missions.
Язык: Английский
Процитировано
7A Systematic Review of Family History, Race/Ethnicity, and Genetic Risk on Prostate Cancer Detection and Outcomes: Considerations in PSA-based Screening
Urologic Oncology Seminars and Original Investigations, Год журнала: 2024, Номер 43(1), С. 29 - 40
Опубликована: Июль 15, 2024
Язык: Английский
Процитировано
4Equitable machine learning counteracts ancestral bias in precision medicine
Nature Communications, Год журнала: 2025, Номер 16(1)
Опубликована: Март 10, 2025
Gold standard genomic datasets severely under-represent non-European populations, leading to inequities and a limited understanding of human disease. Therapeutics outcomes remain hidden because we lack insights that could be gained from analyzing ancestrally diverse data. To address this significant gap, present PhyloFrame, machine learning method for equitable precision medicine. PhyloFrame corrects ancestral bias by integrating functional interaction networks population genomics data with transcriptomic training Application breast, thyroid, uterine cancers shows marked improvements in predictive power across all ancestries, less model overfitting, higher likelihood identifying known cancer-related genes. Validation fourteen demonstrates is better able adjust ancestry populations. The ability provide accurate predictions underrepresented groups, particular, substantially increased. Analysis performance the most continental group, African, illustrates how phylogenetic distance negatively impacts performance, as well PhyloFrame's capacity mitigate these effects. These results demonstrate artificial intelligence (AI) approaches can contribute representation medical research. Ancestral cancer limits effectiveness Here, authors introduce framework adjusts disease signatures based on data, improve medicine ancestries cancers.
Язык: Английский
Процитировано
0Harnessing the Power of Discovery
Cancer Discovery, Год журнала: 2023, Номер 13(4), С. 819 - 823
Опубликована: Март 8, 2023
Summary: Cancer Grand Challenges is an international funding initiative that aims to unite the world's best scientists tackle some of cancer's toughest challenges by team science on a global scale. Here, we discuss nine new, ambitious currently open for application.
Язык: Английский
Процитировано
9Prostate cancer metastasis and health disparities: a systematic review
Prostate Cancer and Prostatic Diseases, Год журнала: 2023, Номер 27(2), С. 183 - 191
Опубликована: Апрель 12, 2023
Язык: Английский
Процитировано
8Understanding inequities in precision oncology diagnostics
Nature Cancer, Год журнала: 2023, Номер 4(6), С. 787 - 794
Опубликована: Май 29, 2023
Язык: Английский
Процитировано
7Global viewpoints: updates on prostate cancer in
BJU International, Год журнала: 2023, Номер 133(1), С. 6 - 13
Опубликована: Сен. 13, 2023
Prostate cancer (PCa) is a major health concern in Sub-Saharan Africa (SSA), with high incidence and mortality rates. However, the widely used prostate-specific antigen (PSA) screening not readily available or affordable SSA. Alternative strategies, such as risk stratification approaches cost-effective PSA tests, are being explored to target high-risk individuals improve access screening. Diagnosis of PCa SSA challenging due lack diagnostic tools limited healthcare resources. Clinical evaluation digital rectal examination commonly used, but testing, magnetic resonance imaging, biopsy often limited. As result, many men diagnosed at advanced stages disease. Treatment options for by resources trained providers. Surgery, radiation therapy, androgen-deprivation therapy may be inaccessible patients. Cultural beliefs stigma surrounding further impact treatment decisions. Improved patient community awareness, electronic medical records, communication between patients professionals can enhance evidence-based decision-making advocate policy changes. Understanding genetic determinants implementing comprehensive strategies lead improved outcomes better control
Язык: Английский
Процитировано
7Estimating disparities of prostate cancer burden and its attributable risk factors for males across the BRICS‐plus, 1990–2019: A comparable study of key nations with emerging economies
The Prostate, Год журнала: 2024, Номер unknown
Опубликована: Фев. 8, 2024
Abstract Backgrounds The study aimed to analyze epidemiology burden of male prostate cancer across the BRICS‐plus, and identify potential risk factors by assessing associations with age, period, birth cohorts sociodemographic index (SDI). Methods Data were extracted from Global Burden Disease Study 2019. average annual percent change (AAPC) was calculated assess long‐term trends, age‐period‐cohort analysis used these three effects on burden. Quantile regression investigate association between SDI health outcomes. Results higher incidence mortality observed in Mercosur SACU regions, increasing trends almost all BRICS‐plus countries (AAPC > 0), EEU's grew 24.31% (%AAPC range: ‐0.13–3.03). Mortality had increased more than half 1.82% 0.62–1.75). Incidence sharply age globally, peak reached group 80–84 years. Rate ratio (RR) except for Kazakhstan where slightly decrease, while RR decreased cohort most countries. presented significantly positive 50 percentiles. deaths attributable smoking declined nations, many China‐ASEAN‐FTA EEU values. Conclusion Prostate posed a serious public challenge an among Age significant burden, recent suffered risk. relationship incidence, smoking‐attributable tremendous region. Secondary prevention should be prioritized policies targeting important populations strengthened based their characteristics adaptability.
Язык: Английский
Процитировано
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