A Comprehensive Primer and Review of PROTACs and Their In Silico Design

Computer Methods and Programs in Biomedicine, Год журнала: 2025, Номер 264, С. 108687 - 108687

Опубликована: Фев. 27, 2025

Язык: Английский

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Targeting KRAS-G12C in Lung Cancer: The Emerging Role of PROTACs in Overcoming Resistance

Pathology - Research and Practice, Год журнала: 2025, Номер unknown, С. 155954 - 155954

Опубликована: Апрель 1, 2025

Язык: Английский

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p53: The Multifaceted Roles of Covalent Modifications in Cancer

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1682 - 1682

Опубликована: Дек. 13, 2024

The p53 protein has attracted huge research interest over several decades due to its role as one of the most important tumor suppressors in mammals, which orchestrates a synchronous response from normal cells body various forms stress. diverse cellular activities are regulated mainly via post-translational modifications (PTMs). PTMs affect on levels: at level assembly tetrameric complexes DNA transactivate target genes, genes; proteolysis absence stress; and contrary, augmented stability stress signals. Disruptions these regulatory mechanisms can lead deviations function, boosting initiation progression. Conversely, targeted interventions pathways could prove beneficial for development antitumor therapies. Advancing our understanding modifiers proteins involved regulation equips researchers with an expanded toolkit studying processes developing biologically active molecules that influence p53-mediated responses.

Язык: Английский

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PROTAC-attractive site as a new target for suppressing P-glycoprotein activity

Archives of Biochemistry and Biophysics, Год журнала: 2024, Номер unknown, С. 110258 - 110258

Опубликована: Дек. 1, 2024

Язык: Английский

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