Efficacy of sorafenib combined with transarterial chemoembolization in the treatment of advanced hepatocellular carcinoma: A meta-analysis

World Journal of Gastrointestinal Oncology, Год журнала: 2025, Номер 17(2)

Опубликована: Янв. 18, 2025

The combination of sorafenib with transarterial chemoembolization (TACE) is being investigated for its potential to improve outcomes in advanced hepatocellular carcinoma (HCC). To evaluate the efficacy this combined treatment strategy enhancing overall survival (OS) and progression-free (PFS) compared monotherapies. A systematic review was conducted following PRISMA guidelines. comprehensive search performed across PubMed, EMBASE, Web Science, Cochrane Library up May 8, 2024. Studies were included if they plus TACE alone or adults HCC. Primary OS, PFS, response rates, safety profiles. Data extraction quality assessment independently by two reviewers. Heterogeneity assessed using I² statistic, a random-effects model applied pooling data. Sensitivity analysis publication bias also conducted. total twelve studies involving 1174 patients met inclusion criteria. Significant heterogeneity observed both OS (I² = 72.6%, P < 0.001) PFS 83.7%, 0.001). significantly improved [hazard ratio (HR) 0.60, 95% confidence interval (CI): 0.44-0.76] (HR 0.54, 95%CI: 0.38-0.69). confirmed robustness these findings. Funnel plots Egger's test indicated no significant bias. Sorafenib enhances HCC monotherapy. This therapy represents promising approach improving clinical liver cancer.

Язык: Английский

CREB1/CRTC2 regulated tubular epithelial-derived exosomal miR-93-3p promotes kidney injury induced by calcium oxalate via activating M1 polarization and macrophage extracellular trap formation

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 12, 2025

Calcium oxalate (CaOx) crystals are known to cause renal injury and trigger inflammatory responses. However, the role of exosome-mediated epithelial-macrophage communication in CaOx-induced kidney remains unclear. To identify key molecules, miRNA sequencing was conducted on exosomes derived from CaOx-treated (CaOx-exo) control (Ctrl-exo) epithelial cells, identifying miR-93-3p as significantly upregulated. A combination dual-luciferase reporter assays, Western blot, RT-qPCR, immunofluorescence staining, flow cytometry, electrophoretic mobility shift assay (EMSA), chromatin immunoprecipitation-qPCR (CHIP-qPCR) used explore regulation by CREB1/CRTC2 its downstream effects NFAT5/Akt1/NIK/NF-κB2 signaling macrophages. The functional roles NFAT5 macrophage polarization extracellular traps (METs) formation were further evaluated both vitro vivo. Epithelial stimulated CaOx found promote via METs formation. Treatment with NIK SMI1, a inhibitor, or CI-amidine, mitigated crystal deposition damage. Overexpression mouse model reduced deposition, downregulated NF-κB2 levels, decreased number M1-polarized Mechanistic studies revealed that directly targets mRNA, confirmed qRT-PCR, blot. Additionally, we demonstrated acts transcriptional activator miR-93-3p. Inhibition partially reversed NIK/NF-κB2 activation alleviated injury. exacerbate interstitial promoting M1 through CREB1/CRTC2–exosomal miR-93-3p–NIK/NF-κB2 pathway. Targeting this pathway may provide therapeutic avenues for mitigating deposition-induced

Язык: Английский

Combination therapy with immune checkpoint inhibitors in colorectal cancer: Challenges, resistance mechanisms, and the role of microbiota

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 186, С. 118014 - 118014

Опубликована: Март 31, 2025

Язык: Английский