Clinical and Applied Thrombosis/Hemostasis, Год журнала: 2024, Номер 30
Опубликована: Янв. 1, 2024
This study aimed to investigate the association between triglyceride-glucose (TyG) index and cryptogenic stroke (CS) in patients diagnosed with patent foramen ovale (PFO) using transesophageal echocardiography (TEE).
Язык: Английский
Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)
Опубликована: Янв. 8, 2024
Abstract Background Obstructive sleep apnea (OSA) has a bidirectional association with metabolic syndrome, and insulin resistance (IR). The triglyceride-glucose (TyG) index could be simply calculated marker of IR in OSA. However, its clinical application appears still limited. Hence, this systematic review meta-analysis aimed to respond question by analyzing all the existing studies showing an between OSA TyG index. Methods Four online databases, including PubMed, Scopus, Web Science, Embase were searched for evaluating After screening data extraction, random-effect was performed compare patients vs. healthy controls calculating standardized mean difference (SMD) 95% confidence interval (CI) pooling area under curves (AUCs) diagnosis based on Results Ten involving 16,726 individuals included current review. Meta-analysis indicated that there significantly higher OSA, compared (SMD 0.856, CI 0.579 1.132, P < 0.001). Also, had diagnostic ability representing pooled AUC 0.681 (95% 0.627 0.735). two studies’ findings, no different severities observed. Finally, our showed is good potential predictor adverse outcomes these patients. Conclusion Our study revealed easy-to-measure assessing both prognosis. supports implementation routine practice help clinicians decision-making patient stratification.
Язык: Английский
Процитировано
41
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Июнь 1, 2024
Abstract Backgrounds Insulin resistance (IR) plays a vital role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, it remains unclear whether triglyceride–glucose (TyG) related parameters, which serve as useful biomarkers to assess IR, have prognostic effects on mortality outcomes MASLD. Methods Participants National Health and Nutrition Examination Survey (NHANES) database from 1999 2018 years were included. TyG its parameters [TyG-waist circumference (TyG-WC) TyG-waist height ratio (TyG-WHtR)] calculated. Kaplan–Meier curves, Cox regression analysis, restricted cubic splines (RCS) conducted evaluate association between TyG-related indices with all-cause cardiovascular adults The concordance index (C-index) was used prediction accuracy indices. Results A total 8208 (4209 men 3999 women, median age 49.00 years) MASLD included this study. Multivariate-adjusted analysis revealed that high quartile levels significantly associated participants [ adjusted hazard (aHR) = 1.25, 95% confidence interval (CI) 1.05–1.50, P 0.014; TyG-WC aHR for 1.28, CI 1.07–1.52, 0.006; TyG-WHtR 1.50, 1.25–1.80, < 0.001; 1.81, 1.28–2.55, 2.22, 1.55–3.17, 0.001]. C-index predicting 0.563 index, 0.579 0.585 respectively. Regarding mortality, 0.561 0.607 0.615 Nonlinear trends observed ( 0.001 0.012, respectively). non-linear relationship 0.025). Subgroup suggested aged 65 old those without comorbidities more sensitive Conclusion Findings study highlight predictive value indices, especially would be surrogate clinical management
Язык: Английский
Процитировано
17
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Май 13, 2024
Abstract Background The relationship between the triglyceride–glucose (TyG) index and risk of cardiovascular disease (CVD) in U.S. population under 65 years age with diabetes or prediabetes is unknown. purpose this study was to investigate baseline TyG CVD patients prediabetes. Methods We used data from 2003–2018 National Health Nutrition Examination Survey (NHANES). Multivariate regression analysis models were constructed explore risk. Nonlinear correlations explored using restricted cubic splines. Subgroup interaction tests also conducted. Results enrolled a total 4340 participants pre-diabetes, mean 9.02 ± 0.02. overall average prevalence 10.38%. Participants higher quartiles showed high rates (Quartile 1: 7.35%; Quartile 2: 10.04%; 3: 10.71%; 4: 13.65%). For CVD, possible association observed. Our findings suggested linear CVD. results revealed U-shaped both (P nonlinear = 0.02583) CHF 0.0208) individuals diabetes. term indicated that there no significant difference among different stratifications. positive comorbid MetS Conclusions A linked an increased likelihood aged ≤ Besides, assessment will contribute more convenient effective screening high-risk MetS. Future studies should whether interventions targeting may improve clinical outcomes these patients.
Язык: Английский
Процитировано
15
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Май 20, 2024
Insulin resistance (IR) is the cornerstone of Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), pathophysiologically being key link between MASLD, metabolic disorders, and cardiovascular (CV) diseases. There are no prospective studies comparing predictive values different markers insulin in identifying presence MASLD associated risk events (CVEs).
Язык: Английский
Процитировано
8
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Июнь 6, 2024
Abstract Background The triglyceride–glucose (TyG) index, a tool for assessing insulin resistance, is increasingly recognized its ability to predict cardiovascular and metabolic risks. However, relationship with trauma surgical patient prognosis understudied. This study investigated the correlation between TyG index mortality risk in surgical/trauma ICU patients identify high-risk individuals improve prognostic strategies. Methods identified requiring trauma/surgical admission from Medical Information Mart Intensive Care (MIMIC-IV) database, divided them into tertiles based on index. outcomes included 28-day 180-day short-term long-term prognosis. associations clinical were elucidated using Cox proportional hazards regression analysis RCS models. Results A total of 2103 enrolled. rates reached 18% 24%, respectively. Multivariate revealed that an elevated was significantly related after covariates adjusting. An associated (adjusted hazard ratio, 1.19; 95% confidence interval 1.04–1.37) 1.24; 1.11–1.39). models progressively increasing According our subgroup analysis, increased critically ill younger than 60 years old, as well those concomitant stroke or diseases. Additionally, nondiabetic patients, mortality. Conclusion In diseases, adverse outcomes. Furthermore, non-diabetic
Язык: Английский
Процитировано
7
Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)
Опубликована: Авг. 22, 2024
Triglyceride-glucose (TyG) index is linked to a poor prognosis for cardiovascular condition and valid indicator of insulin resistance. This study evaluated the potential predicting usefulness TyG all-cause mortality, both short- long-term, those concerning critical coronary artery disease (CAD). In this study, information from 5452 critically-ill individuals with CAD in intensive care units were gathered Medical Information Marketplace Intensive Care (MIMIC-IV) database. Depending on degree, patients categorized into three categories. Clinical outcomes included short-term (30-day) long-term (365-day) mortality. The corresponding relationships involving clinical examined by deploying restricted cubic spline (RCS) regression analysis Cox proportional risk regression. An increased was associated 30-day (Tertile 1: 6.1%, Tertile 2: 7.3%, 3: 9.2%, P = 0.001) 365-day 15.2%, 17.0%, 19.6%, 0.002) death rates across all causes. multiple variables indicates that higher indices all-caused mortality hazard ratios throughout short long terms, larger predictive value former. RCS analyses suggested notably linearly index. reliable predictor at different stages critically ill patients, ability Early intervention elevated may improve their survival outcomes. Future research should delve understanding its pathophysiological mechanisms develop strategies based index, providing new insights enhance outlook patients.
Язык: Английский
Процитировано
5
Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)
Опубликована: Дек. 23, 2024
The Triglyceride-glucose (TyG) index represents a simple, cost-effective, and valid proxy for insulin resistance. This surrogate marker has also been proposed as predictor of metabolic cardiovascular disease (CVD). In this descriptive review, we aimed to assess the utility TyG predictive biomarker cardiometabolic diseases. A search was conducted in PubMed, Web Science identify cross-sectional more importantly prospective studies examining use biomarker. following terms were utilized addition index: "insulin resistance", "metabolic syndrome", "diabetes"; "cardiovascular diseases". review included thirty studies. Following adjustment confounding variables, an elevated associated with significantly increased risk development Metabolic Syndrome (MetS), Type 2 Diabetes, hypertension, CVD. Also limited studies, endothelial dysfunction, oxidative stress pro-inflammatory phenotype. Overall, our findings support developing MetS, T2DM, well atherosclerotic disease.
Язык: Английский
Процитировано
5
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 18, 2025
The triglyceride-glucose (TyG) index, a readily accessible surrogate biomarker for insulin resistance and metabolic health, has been extensively investigated across various ethnic populations. critical role of physical activity (PA) in enhancing sensitivity corroborated by numerous studies. Nonetheless, the relationship between different patterns PA TyG index remains ambiguous. This study seeks to elucidate association index. Participants with complete data on patterns, other covariates from National Health Nutrition Examination Survey database (2007-2018) were included this study. Participant characteristics groups compared using Rao-Scott chi-squared test or Kruskal-Wallis test. Multivariate linear regression models used assess subgroup analyses, interaction tests restricted cubic spline (RCS) analyses conducted explore stability potential nonlinearity PA-TyG association, respectively. A total 16,440 participants included, 12,909, 164, 118, 3249 individuals being inactive, insufficiently active, weekend warriors (WWs), regularly active (RA), adjusted showed that adults (β = - 0.05, P 0.3524), WWs -0.01, 0.9129), RA 0.110, < 0.0001) all had significantly lower indices inactive adults. Significant difference was observed (P trend 0.0001). Stratified interact revealed group more pronounced male, higher education levels, without diabetes. Additionally, significant, non-linear, negative weekly non-inactive determined RCS analysis overall 0.001, 0.054). Being is linked substantial reduction whereas those insufficient do not experience comparable benefits. Nevertheless, warrior approach can provide practical alternative who are unable engage consistent exercise.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 8, 2025
The triglyceride-glucose (TyG) index is emerging as a promising marker for insulin resistance and serves an independent risk predictor cardiovascular outcomes. coronary angiography-derived of microcirculatory (AMR) computed to evaluate microcirculation. However, the association between TyG AMR in patients with type 2 diabetes mellitus (T2DM) ST-segment elevation myocardial infarction (STEMI) remains unclear. We consecutively recruited 168 T2DM STEMI who underwent primary percutaneous intervention (pPCI) at Taizhou People's Hospital from January 2022 December 2023. Patients were classified into low group (AMR < 2.5) high ≥ 2.5). was calculated using formula: ln [plasma triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2]. study enrolled 81 87 group, being significantly higher group. Multivariable logistic regression analysis revealed significant after adjusting confounding variables (odds ratio: 2.449, 95% confidence interval: 1.421–4.220, p = 0.001). area under curve predicting 0.650 (95% 0.57–0.73, 0.001), cut-off value 9.57. Our findings indicate that associated undergoing pPCI, suggesting it may serve valuable this population.
Язык: Английский
Процитировано
0
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Март 14, 2024
Abstract Objective The association of the triglyceride-glucose (TyG) index with intracranial atherosclerotic stenosis (ICAS) and extracranial (ECAS) is unclear. This study aimed to investigate relationship TyG distribution severity ICAS ECAS. Method Patients who underwent digital subtraction angiography (DSA) for evaluating ICAS/ECAS in Zhongnan Hospital Wuhan University from January 2017 October 2021 were retrospectively enrolled our study. Clinical characteristics, DSA data, blood routine, lipid profile fasting glucose recorded. status investigated four aspects: location stenosis, whether symptomatic. Logistic regression models used evaluate association. Restricted cubic splines constructed model non-linear between different arterial status. Results Among 1129 included patients, median age was 62 (IQR 55–68) years, 71.3% male. 8.81 (8.40, 9.21). Elevated significantly associated ICAS, combined ICAS/ECAS, anterior circulation posterior anterior/posterior severe both asymptomatic symptomatic stenosis. maintained after adjusting age, sex, smoking, drinking, medical history hypertension stroke, platelet, total cholesterol, high-density lipoprotein, low-density lipoprotein. Multivariable-adjusted spline showed that a progressively increasing risk related an elevated index. Conclusion ICAS/ECAS. might be useful indicator
Язык: Английский
Процитировано
3