ZBiotics ameliorates T2DM-induced histopathological damage in liver, kidney and adipose tissues by modulating the NOD-like receptor signaling in Wistar rats
Diabetology & Metabolic Syndrome,
Год журнала:
2025,
Номер
17(1)
Опубликована: Фев. 4, 2025
Probiotics
serve
as
promising
candidates
in
type
2
diabetes
mellitus
(T2DM)
therapy.
Not
only
they
presumably
reduce
the
T2DM
prevalence,
but
also
keep
down
its
complications.
In
present
study,
we
explored
beneficial
impact
of
ZBiotics,
an
engineered
probiotic,
on
Wistar
rats.
silico
analysis
was
performed
to
construct
a
genetic-epigenetic
network
linked
STING-NOD
pathway
and
autophagy
signaling.
Then,
30
rats
were
divided
into
5
groups
(each
n
=
6);
normal
group,
diabetic
model,
B.
subtilis,
ZBiotics
treated
at
high
low
doses.
Experimental
procedures
carried
out
including
biochemical
histopathologic
analyses.
Samples
extracted
from
rats'
blood,
liver,
kidney
adipose
tissues.
At
molecular
aspect,
players,
chosen
by
analysis,
assessed
using
2-ΔΔCt
estimate
their
relative
quantification.
With
immunohistochemistry,
TNF-alpha
LC3B
reflectors
for
inflammation
respectively.
reported
ameliorate
T2DM-induced
histological
damage.
Besides,
it
downregulated
upregulated
expression
levels.
corrected
LDL-c
improved
serum
creatinine
CK-MB
Inflammation
relevant
genes
have
been
regarding
CHUK,
NFKB1
miR-611.
Therefore,
is
speculated
operate
modulating
inflammatory
cGAS-STING
recommended
clinical
trials
separate
candidate
or
adjuvant
conventional
Язык: Английский
Association between intra-pancreatic fat deposition and diseases of the exocrine pancreas: A narrative review
World Journal of Gastroenterology,
Год журнала:
2024,
Номер
31(2)
Опубликована: Дек. 18, 2024
Intrapancreatic
fat
deposition
(IPFD)
has
garnered
increasing
attention
in
recent
years.
The
prevalence
of
IPFD
is
relatively
high
and
associated
with
factors
such
as
obesity,
age,
sex.
However,
the
pathophysiological
mechanisms
underlying
remain
unclear,
several
potential
contributing
factors,
including
oxidative
stress,
alterations
gut
microbiota,
hormonal
imbalances.
was
found
to
be
highly
correlated
occurrence
prognosis
exocrine
pancreatic
diseases.
Although
imaging
techniques
primary
diagnostic
approach
for
IPFD,
an
expanding
array
biomarkers
clinical
scoring
systems
have
been
identified
screening
purposes.
Currently,
effective
treatments
are
not
available;
however,
existing
medications,
glucagon-like
peptide-1
receptor
agonists,
new
therapeutic
approaches
explored
animal
models
shown
considerable
managing
this
disease.
This
paper
reviews
pathogenesis
its
association
diseases,
advancements
diagnosis
treatment,
emphasizing
significant
relevance
IPFD.
Язык: Английский