Soy-derived materials: a sustainable resource and their applications in medicine and tissue engineering DOI Creative Commons
Uyen M. N. Cao, Janaki Iyer, Riho Kanai

и другие.

Deleted Journal, Год журнала: 2024, Номер 1(1)

Опубликована: Дек. 19, 2024

As the trend of 'green medicine' has emerged robustly over past decades, an expanding demand for sustainable development biomaterials led scientists to shift their attention more alternatives such as plant-derived products, especially soybean-derived products. The cultivation soy farms, if performed responsibly, can generate fewer greenhouse gases than synthetic or animal-derived materials generate, leading a lower environmental footprint. In this narrative review, first, we briefly summarize history soy-based materials, how they have been used in different cultures worldwide thousands years, and bioactive components, including proteins, isoflavones, lecithin, other minerals. Our review will also discuss sustainability these greater depth, with focus on biodegradability, biocompatibility, renewable nature multiple applications current medicine tissue engineering areas. While products proven be promising, eco-friendly fields, much effort further research are needed optimize performance scalability before fully applied clinical settings future.

Язык: Английский

Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus DOI Open Access
Monika Martiniaková, Anna Šarocká,

Noémi Pénzes

и другие.

Nutrients, Год журнала: 2025, Номер 17(2), С. 275 - 275

Опубликована: Янв. 13, 2025

Type 2 diabetes mellitus (T2DM), a serious metabolic disorder, is worldwide health problem due to the alarming rise in prevalence and elevated morbidity mortality. Chronic hyperglycemia, insulin resistance, ineffective effect secretion are hallmarks of T2DM, leading many secondary complications. These include, particular, cardiovascular disorders, diabetic neuropathy, nephropathy retinopathy, foot, osteoporosis, liver damage, susceptibility infections some cancers. Polyphenols such as flavonoids, phenolic acids, stilbenes, tannins, lignans constitute an extensive heterogeneous group phytochemicals fresh fruits, vegetables their products. Various vitro studies, animal model studies available clinical trials revealed that flavonoids (e.g., quercetin, kaempferol, rutin, epicatechin, genistein, daidzein, anthocyanins), acids chlorogenic, caffeic, ellagic, gallic curcumin), stilbenes resveratrol), tannins procyanidin B2, seaweed phlorotannins), pinoresinol) have ability lower enhance sensitivity improve secretion, scavenge reactive oxygen species, reduce chronic inflammation, modulate gut microbiota, alleviate complications T2DM. The interaction between polyphenols conventional antidiabetic drugs offers promising strategy management treatment especially advanced disease stages. Synergistic effects with been documented, but also antagonistic interactions may impair drug efficacy. Therefore, additional research required clarify mutual order use knowledge applications. Nevertheless, dietary can be successfully applied part supportive for they both obvious symptoms

Язык: Английский

Процитировано

2
The Role of Gut Microbiota in Disease management: Ayurvedic Perspectives on Metabolic Diseases and Health DOI Creative Commons

Bhawana Jangra,

Shreyanshi Kulshreshtha,

Alok Kumar Goyal

и другие.

Phytomedicine Plus, Год журнала: 2025, Номер unknown, С. 100731 - 100731

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Bioavailability study of enantiopure (S)-Equol in CD(SD)IGS rats DOI Creative Commons

Seethakallu Ramachandraiah AnandaKumar,

Mukund Handral,

Srinivas Seekallu

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 24, 2025

The therapeutic potential of (S)-Equol across various health domains, including mental and oncology has been identified studied enormously. However, the pharmacokinetic study on enantiopure in male female rats under graded doses remain untouched, concentrates same. Male CD(SD)IGS were grouped into 8 groups some administered with 20, 60 160 mg/kg body weight, orally other intravenous bolus injection at 10 weight (S)-Equol. plasma concentrations estimated by LC-MS/MS parameters determined from concentration time data non-compartmental PK analysis. observed Cmax was 66.78, 659.38, 2542.02 ng/mL males 392.08, 1661.97, 4879.36 rats, similarly, AUCLast 118.96, 1130.32, 4876.00 h*ng/mL 2164.01, 4883.09, 14067.94 dose respectively. administration showed 8563.25, 8642.91 3742.98, 3551.90 oral bioavailability found to be 1.59, 5.03, 8.14% 30.46, 22.91, 66.01% These suggesting that gender related differences exposure, increased exposure mg/mL comparable exposures rats.

Язык: Английский

Процитировано

0
Role of Microbiota‐Derived Metabolites in Prostate Cancer Inflammation and Progression DOI Open Access
Pradeep Kumar Rathinavelu, Anil Kumar, Virendra Kumar

и другие.

Cell Biochemistry and Function, Год журнала: 2025, Номер 43(2)

Опубликована: Янв. 31, 2025

Prostate cancer (PCa) is the most commonly detected malignancy in men worldwide. PCa a slow-growing with absence of symptoms at early stages. The pathogenesis has not been entirely understood including key risk factors related to development like diet and microbiota derived metabolites. Microbiota may influence host's immunological responses, inflammatory metabolic pathways, which be crucial for metastasis. Similarly, short-chain fatty acids, methylamines, hippurate, bile other metabolites generated by have potential roles inflammation progression cancer. Most studies focused on role their pathways involved chronic inflammation, tumor initiation, proliferation, progression. In summary, review discusses microbial-derived metabolite-built strategies PCa.

Язык: Английский

Процитировано

0
Inverted U-shape association between urine equol levels and cancer: a national population-based cross-sectional study DOI Creative Commons

Jufa Li,

Jing Lv,

Yuwei Zhang

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 28, 2025

Equol, a naturally occurring phytoestrogen derived from the fermentation of soy and soy-based products by gut bacteria, is recognized for its diverse health benefits. While there speculation about association with cancer prevention, scientific community has yet to reach consensus due variability in research findings. Our study aims shed light on this topic examining correlation between urine equol concentrations risk among American population. The National Health Nutrition Examination Survey (NHANES) national survey U.S. civilians which participants are enrolled database sample questionnaire. This included 2797 Americans aged 40 years older NHANES (2005–2010). relationship concentration was analysed using weighted logistic regression models, stratified analysis, smoothed curve fitting threshold effect analysis were also performed. Among our study, 390 individuals received diagnosis. findings indicate positive levels cancer. Notably, highest quartile excretion exhibited significantly elevated cancer, 25.4% increase compared those lowest (POR = 1.254, 95% CI: 1.252, 1.256), after fully adjusting confounders. Similar results observed other adjusted models. A non-linear shape an inverted U-shape can be fitting, inflection point 25.5. Urinary below 25.5 ng/ml positively associated risk, while above showed slight negative trend risk. However, further prospective studies needed provide more robust evidence confirmed large clinical trials.

Язык: Английский

Процитировано

0
Gut microbiota-derived metabolite phenylacetylglutamine inhibits the progression of prostate cancer by suppressing the Wnt/β-catenin signaling pathway DOI Creative Commons

Jing Lv,

Shengkai Jin,

Yuhua Zhou

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 11, 2025

Background Prostate cancer is one of the most common malignant tumors among men worldwide, and current treatments still face many challenges. Therefore, researchers are continuously seeking new therapeutic methods to improve treatment efficacy reduce side effects. Phenylacetylglutamine (PAGln), a metabolite gut microbiota, has been reported have anti-inflammatory anti-tumor activities. Methods We assessed impact PAGln on prostate using in vitro vivo models. Cell proliferation, migration, invasion capabilities were evaluated through CCK8, EdU incorporation, colony formation assays, as well wound healing Transwell assays. The anti-cancer effects BALB/c nude mouse xenograft model lung metastatic tumor established via tail vein injection. Molecular mechanisms investigated qRT-PCR Western blot analysis. Results inhibited (PCa) cells suppressed growth . notably increased mRNA levels CCNG2 PCa cells. Importantly, knockdown weakened Mechanistic studies revealed that could promote phosphorylation β-catenin by upregulating CCNG2, thereby inhibiting Wnt/β-catenin signaling pathway. Conclusion In summary, can effectively inhibit suppressing These findings suggest may serve promising agent for cancer.

Язык: Английский

Процитировано

0
Chemoprevention of phytoestrogens on women hormone-related cancers by integrating text mining and data mining approaches DOI
Sheng‐I Chen,

Guan-Jun Lin,

Yi-Nung Tsao

и другие.

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106368 - 106368

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Sex-specific associations between diet quality and mortality in adults with diabetes: findings from NHANES 2001-2018 DOI Creative Commons

Youqi Zhang,

Yan Meng,

Liu Ji

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 16, 2025

Objective To investigate the impact of diet on cardiovascular (CV)/all-cause mortality among individuals with diabetes, and to explore whether this relationship changes by gender. Methods We collected data from National Health Nutrition Examination Survey (NHANES) database pertaining 5,875 diabetes (3,068 males 2,807 females) used Healthy Eating Index (HEI), Alternative (AHEI), alternative Mediterranean Diet (aMED) index assess quality. Multivariate Cox models were determine association between dietary quality scores CV/all-cause mortality, stratified genders. Dose–response relationships assessed using Restricted Cubic Spline (RCS). As a secondary objective, further analysis was conducted connection different components. Results During median 9.25-year follow-up period, we observed 1,488 all-cause deaths, including 486 CV deaths. Sex-stratified analyses revealed that higher quality, as indicated each standard deviation increase in score, significantly associated reduced risk ( p < 0.05). No significant associations females > Among component aMED, legume intake unfavorable for but remarkably lower females. Conclusion In diabetic population, high are not

Язык: Английский

Процитировано

0
Soy-derived materials: a sustainable resource and their applications in medicine and tissue engineering DOI Creative Commons
Uyen M. N. Cao, Janaki Iyer, Riho Kanai

и другие.

Deleted Journal, Год журнала: 2024, Номер 1(1)

Опубликована: Дек. 19, 2024

As the trend of 'green medicine' has emerged robustly over past decades, an expanding demand for sustainable development biomaterials led scientists to shift their attention more alternatives such as plant-derived products, especially soybean-derived products. The cultivation soy farms, if performed responsibly, can generate fewer greenhouse gases than synthetic or animal-derived materials generate, leading a lower environmental footprint. In this narrative review, first, we briefly summarize history soy-based materials, how they have been used in different cultures worldwide thousands years, and bioactive components, including proteins, isoflavones, lecithin, other minerals. Our review will also discuss sustainability these greater depth, with focus on biodegradability, biocompatibility, renewable nature multiple applications current medicine tissue engineering areas. While products proven be promising, eco-friendly fields, much effort further research are needed optimize performance scalability before fully applied clinical settings future.

Язык: Английский

Процитировано

0