Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns DOI Creative Commons
Hudson P. Santos, Adam E. Enggasser,

Jeliyah Clark

и другие.

BMC Biology, Год журнала: 2023, Номер 21(1)

Опубликована: Авг. 23, 2023

Health outcomes among children born prematurely are known to be sexually dimorphic, with male infants often more affected, yet the mechanism behind this observation is not clear. CpG methylation levels in placenta and blood also differ by sex associated adverse health outcomes. We contrasted neonatal (n = 358) from Extremely Low Gestational Age Newborn (ELGAN) cohort based on EPIC array, which assays over 850,000 sites across epigenome. Sex-specific epigenome-wide association analyses were conducted for samples independently, results compared determine tissue-specific differences between patterns males females. All models adjusted cell type heterogeneity. Enrichment pathway analysis was performed identify biological functions of genes related dimorphic sites.Approximately 11,500 differentially methylated relation sex. Of these, 5949 placenta-specific 5361 blood-specific, only 233 overlapping both tissues. For sites, 90% hypermethylated males. blood-specific 95% In placenta, keratinocyte differentiation pathways enriched genes. No enrichment observed blood.Distinct female extremely premature, placenta. These findings provide new insights into epigenetic mechanisms underlying premature infants.

Язык: Английский

Immune targeting of HIV-1 reservoir cells: a path to elimination strategies and cure DOI
Marie Armani-Tourret, Benjamin Bone, Toong Seng Tan

и другие.

Nature Reviews Microbiology, Год журнала: 2024, Номер 22(6), С. 328 - 344

Опубликована: Фев. 9, 2024

Язык: Английский

Процитировано

23
Sex-specific mechanisms in vascular aging: exploring cellular and molecular pathways in the pathogenesis of age-related cardiovascular and cerebrovascular diseases DOI Creative Commons
Anna Ungvari, Rafał Gulej, Roland Patai

и другие.

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Язык: Английский

Процитировано

3
Quality control and analytic best practices for testing genetic models of sex differences in large populations DOI Creative Commons
Ekaterina Khramtsova, Melissa A. Wilson, Joanna Martin

и другие.

Cell, Год журнала: 2023, Номер 186(10), С. 2044 - 2061

Опубликована: Май 1, 2023

Язык: Английский

Процитировано

27
Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions DOI Creative Commons

Bhavisha Doshi,

Sarah R. Athans, Anna Woloszynska‐Read

и другие.

Oncogenesis, Год журнала: 2023, Номер 12(1)

Опубликована: Сен. 4, 2023

Abstract Sex and gender disparities in bladder cancer have long been a subject of interest to the research community, wherein men 4 times higher incidence rate than women, female patients often present with higher-grade disease experience worse outcomes. Despite known differences clinical outcomes between male patients, management remains same. In this review, we critically analyze studies that report on biological women evaluate how these contribute sex cancer. Distinct characteristics immune systems, circulating hormone levels receptor expression, different genetic epigenetic alterations are major factors all likely disparate rates for patients. Future preclinical area should employ experimental approaches account consider cancer, thereby facilitating development precision medicine effective treatment

Язык: Английский

Процитировано

26
Comprehensive evaluation of smoking exposures and their interactions on DNA methylation DOI Creative Commons
Thanh T. Hoang, Yunsung Lee, Daniel L. McCartney

и другие.

EBioMedicine, Год журнала: 2024, Номер 100, С. 104956 - 104956

Опубликована: Янв. 9, 2024

BackgroundSmoking impacts DNA methylation, but data are lacking on smoking-related differential methylation by sex or dietary intake, recent smoking cessation (<1 year), persistence of from in utero exposure, and effects environmental tobacco smoke (ETS).MethodsWe meta-analysed up to 15,014 adults across 5 cohorts with measured blood using Illumina's EPIC array for current (2560 exposed), quit < 1 year (500 (286 ETS exposure (676 exposed). We also evaluated the interaction diet (fibre, folate, vitamin C).FindingsUsing false discovery rate (FDR 0.05), 65,857 CpGs were differentially methylated relation smoking, 4025 quitting, 594 6 ETS. Most attenuated within a quitting. related enriched those previously observed newborns. Differential at 4–71 may be modified intake. Nearly half (35–50%) 450 K associated gene expression. Current implicated 3049 1067 druggable targets, including chemotherapy drugs.InterpretationMany sites identified array. signals revert levels never smokers cessation. Many persist into adulthood. Smoking-related targets provide insights cancer treatment response shared mechanisms diseases.FundingIntramural Research Program National Institutes Health, Norwegian Ministry Health Care Services Education Research, Chief Scientist Office Scottish Government Directorates Funding Council, Medical Council UK Wellcome Trust.

Язык: Английский

Процитировано

15
Epigenetic developmental mechanisms underlying sex differences in cancer DOI Creative Commons
Joshua B. Rubin,

Tamara Abou-Antoun,

Joseph E. Ippolito

и другие.

Journal of Clinical Investigation, Год журнала: 2024, Номер 134(13)

Опубликована: Июнь 30, 2024

Cancer risk is modulated by hereditary and somatic mutations, exposures, age, sex, gender. The mechanisms which sex gender work alone in combination with other cancer factors remain underexplored. In general, cancers that occur both the male female sexes more commonly XY compared XX individuals, regardless of genetic ancestry, geographic location, age. Moreover, individuals are less frequently cured their cancers, highlighting need for a greater understanding effects oncology. This will be necessary optimal laboratory clinical investigations. To end, we review epigenetics sexual differentiation its effect on hallmark pathways throughout life. Specifically, touch how differences metabolism, immunity, pluripotency, tumor suppressor functions patterned through epigenetic imprinting, chromosome complement, X inactivation, genes escaping hormones, life history.

Язык: Английский

Процитировано

8
Immune dynamics throughout life in relation to sex hormones and perspectives gained from gender-affirming hormone therapy DOI Creative Commons
Ahmet Yalçınkaya, Rümeysa Yalçınkaya,

Fabian Sardh

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 16, 2025

Biological sex is closely associated with the properties and extent of immune response, males females showing different susceptibilities to diseases variations in immunity. Androgens, predominantly males, generally suppress responses, while estrogens, more abundant females, tend enhance It also established that hormones at least partially explain biases diseases, particularly autoimmune females. These differences are influenced by hormonal, genetic, environmental factors, vary throughout life stages. The advent gender-affirming hormone therapy offers a novel opportunity study immunological effects hormones. Despite limited studies on this topic, available research has revealed testosterone transgender men may certain functions, such as type I interferon increasing inflammation markers like TNF-α. Transgender women estrogen experience alterations coagulation-related inflammatory characteristics. Furthermore, other possible regulation can be inferred from assessment individuals receiving therapy. Understanding complex interactions between system, through unique perspective offered therapies, facilitate development targeted therapies for infections improving healthcare outcomes individuals. Here we review dynamics both sexes provide summary findings drawn exploring

Язык: Английский

Процитировано

1
Epigenetic Mechanisms Underlying Sex Differences in Neurodegenerative Diseases DOI Creative Commons
Andrea Stoccoro

Biology, Год журнала: 2025, Номер 14(1), С. 98 - 98

Опубликована: Янв. 19, 2025

Neurodegenerative diseases are characterized by profound differences between females and males in terms of incidence, clinical presentation, disease progression. Furthermore, there is evidence suggesting that sensitivity to medical treatments may exist the two sexes. Although role sex hormones chromosomes driving differential susceptibility these well-established, molecular alterations underlying remain poorly understood. Epigenetic mechanisms, including DNA methylation, histone tail modifications, activity non-coding RNAs, strongly implicated pathogenesis neurodegenerative diseases. While it known epigenetic mechanisms play a crucial sexual differentiation distinct patterns characterize males, sex-specific have been largely overlooked studies aiming identify associated with This review aims provide an overview processes central nervous system, main three diseases, Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis. Understanding sex-related essential for developing personalized interventions account unique landscapes each sex.

Язык: Английский

Процитировано

1
Sex-specific DNA methylation: impact on human health and development DOI
Priyanka Govender, Meenu Ghai,

Moses Okpeku

и другие.

Molecular Genetics and Genomics, Год журнала: 2022, Номер 297(6), С. 1451 - 1466

Опубликована: Авг. 15, 2022

Язык: Английский

Процитировано

28
Canonical correlation analysis for multi-omics: Application to cross-cohort analysis DOI Creative Commons
Min-Zhi Jiang, François Aguet, Kristin Ardlie

и другие.

PLoS Genetics, Год журнала: 2023, Номер 19(5), С. e1010517 - e1010517

Опубликована: Май 22, 2023

Integrative approaches that simultaneously model multi-omics data have gained increasing popularity because they provide holistic system biology views of multiple or all components in a biological interest. Canonical correlation analysis (CCA) is correlation-based integrative method designed to extract latent features shared between assays by finding the linear combinations features–referred as canonical variables (CVs)–within each assay achieve maximal across-assay correlation. Although widely acknowledged powerful approach for data, CCA has not been systematically applied large cohort studies, which only recently become available. Here, we adapted sparse (SMCCA), widely-used derivative CCA, proteomics and methylomics from Multi-Ethnic Study Atherosclerosis (MESA) Jackson Heart (JHS). To tackle challenges encountered when applying SMCCA MESA JHS, our adaptations include incorporation Gram-Schmidt (GS) algorithm with improve orthogonality among CVs, development Sparse Supervised Multiple (SSMCCA) allow supervised integration more than two assays. Effective application real datasets reveals important findings. Applying SMCCA-GS identified strong associations blood cell counts protein abundance, suggesting adjustment composition should be considered protein-based association studies. Importantly, CVs obtained independent cohorts also demonstrate transferability across cohorts. For example, proteomic learned transferred MESA, explain similar amounts count phenotypic variance explaining 39.0% ~ 50.0% variation JHS 38.9% 49.1% MESA. Similar was observed other omics-CV-trait pairs. This suggests biologically meaningful cohort-agnostic captured CVs. We anticipate SSMCCA on various would help identify relationships traits.

Язык: Английский

Процитировано

17