Robotic Resection of Colonic Medullary Carcinoma: A Case Report

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Colorectal medullary carcinoma (MC) is a rare and distinct subtype of colorectal cancer associated with mismatch repair (MMR) deficiency the loss MLH1 PMS2 genes. Due to its incidence atypical histopathological features, MC often misclassified as poorly differentiated adenocarcinoma. We present case an 87-year-old elderly male iron anemia right-sided abdominal mass. Initial colonoscopy biopsy reported adenocarcinoma, but subsequent surgical resection confirmed MC. The patient elected undergo right hemicolectomy via robotic-assisted approach. Although potential oncologic benefit robotic surgery remains uncertain, it was chosen in this due patient's preference for minimally invasive procedure, his advanced age, tumor's relatively large size. No adjuvant therapy recommended after multidisciplinary review given MMR absence regional lymph node metastasis. This report highlights diagnostic challenges benefits approach resections patient.

Язык: Английский

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Medullary carcinoma of the left colon in a 16-year-old male: an extremely rare case report from Syria

Annals of Medicine and Surgery, Год журнала: 2025, Номер 87(3), С. 1741 - 1745

Опубликована: Фев. 26, 2025

Introduction and importance: Medullary carcinoma (MC) is a rare type of colon that accounts for less than 1% colorectal neoplasms. Morphologically, MC resembles many cancer (CRC) subtypes, mainly Neuroendocrine Carcinoma (NEC) due to exhibiting neuroendocrine features. In consequence, exceedingly challenging detect; numerous immunohistochemistry tests are required in order distinguish it from the other subtypes CRC. Case presentation: We report case 16-year-old male who presented with severe abdominal pain symptoms bowel obstruction. Computed tomography scan showed mass descending colon. The patient underwent an emergency colectomy. left part transverse colon, sigmoid were removed, along regional lymph nodes. Microscopic examination suggested NEC, whereas immunohistochemical staining confirmed diagnosis After surgery, course chemotherapy was administered. Clinical discussion: usually presents elderly Caucasian women, observed right Therefore, highly unusual appear boy’s based on microscopic tests. optimal management combined chemotherapy, some cases full colectomy needed. Conclusion: purpose this paper highlight dilemma diagnosing as well successful through surgical intervention, post-operative care.

Язык: Английский

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Synergistic potential of CDH3 in targeting CRC metastasis and enhancing immunotherapy

BMC Cancer, Год журнала: 2025, Номер 25(1)

Опубликована: Март 28, 2025

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, particularly due to advanced-stage metastasis. P-cadherin (CDH3), potential therapeutic target, is highly expressed in CRC tissues and associated with poor prognosis However, the mechanisms underlying its role progression translational remain poorly understood. This study integrated multiple public databases (TCGA, HCMDB, UALCAN, HPA, UniProt, cBioPortal, GEO) evaluate CDH3 expression, construct prognostic model, perform functional analyses. Immunohistochemistry was used validate protein expression clinical samples. Additional analyses included correlations clinicopathological parameters, immune infiltration (TIDE, TISIDB), enrichment (KEGG, GSEA), drug sensitivity (GSCA), molecular docking (MOE). Single-cell sequencing (CancerSEA, HPA) also conducted explore CDH3's at single-cell level. significantly elevated correlated prognosis, recurrence, resting cells, dendritic analysis revealed critical metastasis through extracellular matrix (ECM) local adhesion pathways. Notably, afatinib emerged as promising candidate for targeting via "drug repositioning," process involving repurposing existing drugs new applications. provides novel insights into target. The CDH3, including integration immunotherapy repositioning strategies, offers avenue treatment metastatic CRC.

Язык: Английский

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Risk factor analysis and nomogram development and verification for medullary carcinoma of the colon using SEER database

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 19, 2024

Abstract Medullary Carcinoma of the Colon (MCC) is a rare histological subtype colon cancer, and there currently no recognized optimal treatment plan for it, with its prognosis remaining unclear. The aim this study to analyze independent prognostic factors MCC patients develop validate nomograms predict overall survival (OS). A total 760 newly diagnosed from 2004 2020 were selected Surveillance, Epidemiology, End Results (SEER) database. All randomly allocated training group validation in 7:3 ratio. Univariate multivariable Cox regression analyses conducted identify construct nomograms. nomogram prediction model was evaluated validated using receiver operating characteristic (ROC) curves, calibration decision curve analysis (DCA). found that elderly women are more susceptible MCC, ascending cecum most common sites involvement. poorly differentiated, stages II III being common. Surgery primary MCC. stage IV poor, median time only 10 months. Independent include age, N stage, M surgery, chemotherapy, tumor size. Among them, age < 75 years completion chemotherapy protective medullary carcinoma, while N2 (HR = 2.18, 95%CI 1.40–3.38), M1 3.31, 2.01–5.46), surgery 27.94, 3.69–211.75), diameter > 7 cm 1.66, 1.20–2.30) risk carcinoma. results ROC, AUC, DCA demonstrate exhibits good predictive performance. We have updated demographic characteristics carcinoma identified staging, size as Additionally, we established prediction. These can provide personalized predictions serve valuable references clinical decision-making.

Язык: Английский

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Correction: Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literature

Journal of Medical Case Reports, Год журнала: 2023, Номер 17(1)

Опубликована: Ноя. 1, 2023

Язык: Английский

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