Fundamental Research,
Год журнала:
2023,
Номер
3(5), С. 692 - 706
Опубликована: Июнь 12, 2023
Tumorigenesis
is
a
complicated
process
in
which
numerous
modulators
are
involved
different
ways.
Previous
studies
have
focused
primarily
on
tumor-associated
protein-coding
genes
such
as
oncogenes
and
tumor
suppressor
genes,
well
their
associated
oncogenic
pathways.
However,
noncoding
RNAs
(ncRNAs),
rising
stars
diverse
physiological
pathological
processes,
recently
emerged
additional
tumorigenesis.
In
this
review,
we
focus
two
typical
kinds
of
ncRNAs:
long
(lncRNAs)
circular
(circRNAs).
We
describe
the
molecular
patterns
ncRNAs
roles
cancer
stem
cells
(CSCs),
cells,
environmental
cells.
CSCs
small
subset
generally
considered
to
be
that
initiate
tumorigenesis,
dozens
been
defined
critical
CSC
maintenance
oncogenesis.
Moreover,
widely
oncogenetic
including
sustaining
proliferation,
resisting
cell
death,
genome
instability,
metabolic
disorders,
immune
escape
metastasis.
also
discuss
potential
applications
diagnosis
therapy.
The
progress
ncRNA
research
greatly
improves
our
understanding
oncogenesis
provides
new
targets
for
future
Experimental Hematology and Oncology,
Год журнала:
2025,
Номер
14(1)
Опубликована: Апрель 10, 2025
Abstract
Tumor
microenvironment
(TME)
is
a
complex
ecosystem
composed
of
both
cellular
and
non-cellular
components
that
surround
tumor
tissue.
The
extracellular
matrix
(ECM)
key
component
the
TME,
performing
multiple
essential
functions
by
providing
mechanical
support,
shaping
regulating
metabolism
signaling,
modulating
immune
responses,
all
which
profoundly
influence
cell
behavior.
quantity
cross-linking
status
stromal
are
primary
determinants
tissue
stiffness.
During
development,
ECM
stiffness
not
only
serves
as
barrier
to
hinder
drug
delivery
but
also
promotes
cancer
progression
inducing
stimulation
activates
membrane
receptors
sensors.
Thus,
comprehensive
understanding
how
regulates
crucial
for
identifying
potential
therapeutic
targets
cancer.
This
review
examines
effects
on
progression,
encompassing
proliferation,
migration,
metastasis,
resistance,
angiogenesis,
epithelial-mesenchymal
transition
(EMT),
evasion,
stemness,
metabolic
reprogramming,
genomic
stability.
Finally,
we
explore
strategies
target
their
implications
progression.
Cancers,
Год журнала:
2023,
Номер
15(15), С. 3836 - 3836
Опубликована: Июль 28, 2023
Cancer
is
an
impending
bottleneck
in
the
advanced
scientific
workflow
to
achieve
diagnostic,
prognostic,
and
therapeutic
success.
Most
cancers
are
refractory
conventional
diagnostic
chemotherapeutics
due
their
limited
targetability,
specificity,
solubility,
side
effects.
The
inherent
ability
of
each
cancer
evolve
through
various
genetic
epigenetic
transformations
metabolic
reprogramming
underlies
limitations.
Though
tumor
microenvironments
(TMEs)
quite
well
understood
some
cancers,
microenvironment
differs
from
other
internal
perturbations
skew
thereby
impeding
development
appropriate
diagnostics,
drugs,
vaccines,
therapies.
associated
bioenergetics
modulations
regulate
TME,
angiogenesis,
immune
evasion,
generation
resistant
niches
progression,
a
thorough
understanding
crucial
However,
this
remains
missing
element
theranostics,
necessitating
modalities
that
can
be
adapted
for
diagnostics
therapeutics.
In
challenging
scenario,
nanomaterials
modular
platforms
TME
achieving
successful
theranostics.
Several
nanoscale
particles
have
been
successfully
researched
animal
models,
few
reached
clinical
trials,
achieved
Nanoparticles
exhibit
intrinsic
capability
interact
with
diverse
biomolecules
modulate
functions.
Furthermore,
nanoparticles
functionalized
receptors,
modulators,
drugs
facilitate
specific
targeting
reduced
toxicity.
This
review
discusses
current
different
theranostic
nanosystems,
synthesis,
functionalization,
targetability
modulation
bioenergetics,
microenvironment.
We
highlight
potential
nanosystems
enhanced
chemotherapeutic
success
emphasizing
questions
remain
unanswered.
ACS Nano,
Год журнала:
2023,
Номер
17(23), С. 23262 - 23298
Опубликована: Ноя. 27, 2023
Cancer
stem
cells
(CSCs)
drive
tumor
initiation,
progression,
and
therapeutic
resistance
due
to
their
self-renewal
differentiation
capabilities.
Despite
encouraging
progress
in
cancer
treatment,
conventional
approaches
often
fail
eliminate
CSCs,
necessitating
the
development
of
precise
targeted
strategies.
Recent
advances
materials
science
nanotechnology
have
enabled
promising
CSC-targeted
approaches,
harnessing
power
tailoring
nanomaterials
diverse
applications.
This
review
provides
an
update
on
current
landscape
nanobased
precision
targeting
against
CSCs.
We
elucidate
nuanced
application
organic,
inorganic,
bioinspired
across
a
spectrum
paradigms,
encompassing
therapy,
immunotherapy,
multimodal
synergistic
therapies.
By
examining
accomplishments
challenges
this
potential
field,
we
aim
inform
future
efforts
advance
nanomaterial-based
therapies
toward
more
effective
"sniping"
CSCs
clearance.
Fundamental Research,
Год журнала:
2023,
Номер
3(5), С. 692 - 706
Опубликована: Июнь 12, 2023
Tumorigenesis
is
a
complicated
process
in
which
numerous
modulators
are
involved
different
ways.
Previous
studies
have
focused
primarily
on
tumor-associated
protein-coding
genes
such
as
oncogenes
and
tumor
suppressor
genes,
well
their
associated
oncogenic
pathways.
However,
noncoding
RNAs
(ncRNAs),
rising
stars
diverse
physiological
pathological
processes,
recently
emerged
additional
tumorigenesis.
In
this
review,
we
focus
two
typical
kinds
of
ncRNAs:
long
(lncRNAs)
circular
(circRNAs).
We
describe
the
molecular
patterns
ncRNAs
roles
cancer
stem
cells
(CSCs),
cells,
environmental
cells.
CSCs
small
subset
generally
considered
to
be
that
initiate
tumorigenesis,
dozens
been
defined
critical
CSC
maintenance
oncogenesis.
Moreover,
widely
oncogenetic
including
sustaining
proliferation,
resisting
cell
death,
genome
instability,
metabolic
disorders,
immune
escape
metastasis.
also
discuss
potential
applications
diagnosis
therapy.
The
progress
ncRNA
research
greatly
improves
our
understanding
oncogenesis
provides
new
targets
for
future
