Exosomes as Rheumatoid Arthritis Diagnostic Biomarkers and Therapeutic Agents

Vaccines, Год журнала: 2023, Номер 11(3), С. 687 - 687

Опубликована: Март 17, 2023

Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder that causes systemic inflammation, autoimmunity, and abnormalities result in permanent disability. Exosomes are nanosized extracellular particles found mammals (40–100 nm). They transporter of lipids, proteins, genetic material involved mammalian cell–cell signaling, biological processes, cell signaling. have been identified as playing role rheumatoid arthritis-related inflammation (RA). Uniquely functioning vesicles (EVs) responsible for the transport autoantigens mediators between distant cells. In addition, paracrine factors, such exosomes, modulate immunomodulatory function mesenchymal stem cells (MSCs). addition to transporting information, exosomes convey miRNAs studied drug delivery vehicles. animal models, it has observed MSCs secrete EVs with properties, promising results this area. By understanding diversity exosomal contents their corresponding targets, may be possible diagnose autoimmune diseases. can employed diagnostic biomarkers immunological disorders. We here discuss most recent findings regarding diagnostic, prognostic, therapeutic potential these nanoparticles provide an overview evidence pertaining biology RA.

Язык: Английский

---

Extracellular Vesicles and Exosomes: Novel Insights and Perspectives on Lung Cancer from Early Detection to Targeted Treatment

Biomedicines, Год журнала: 2024, Номер 12(1), С. 123 - 123

Опубликована: Янв. 7, 2024

Lung cancer demands innovative approaches for early detection and targeted treatment. In addressing this urgent need, exosomes play a pivotal role in revolutionizing both the treatment of lung cancer. Their remarkable capacity to encapsulate diverse range biomolecules, traverse biological barriers, be engineered with specific targeting molecules makes them highly promising diagnostic markers precise drug delivery cells. Furthermore, an in-depth analysis exosomal content biogenesis offers crucial insights into molecular profile tumors. This knowledge holds significant potential development therapies strategies Despite notable progress field, challenges standardization cargo loading persist. Collaborative research efforts are imperative maximize advance field precision medicine benefit patients.

Язык: Английский

---

Exosomes in Cancer: Diagnostic and Therapeutic Applications

Clinical Medicine Insights Oncology, Год журнала: 2024, Номер 18

Опубликована: Янв. 1, 2024

Small extracellular vesicles called exosomes are produced by cells and contain a range of biomolecules, including proteins, lipids, nucleic acids. Exosomes have been implicated in the development spread cancer, recent studies shown that their contents may be exploited as biomarkers for early detection ongoing surveillance disease. In this review article, we summarize current knowledge on cancer. We discuss various methods used exosome isolation characterization, well different types biomolecules found within relevant cancer diagnosis prognosis. also highlight demonstrated utility exosomal such lung breast pancreatic Overall, show great promise noninvasive monitoring. ability to transform diagnostic therapeutic paradigms, providing more efficient individualized. This seeks serve an inspiration new ideas research never-ending fight against Moreover, further needed validate clinical establish standardized protocols analysis. With continued development, potential revolutionize treatment.

Язык: Английский

---

Drug delivery strategies with lipid-based nanoparticles for Alzheimer’s disease treatment

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 10, 2025

Alzheimer's disease (AD) is a distinctive form of dementia characterized by age-related cognitive decline and memory impairment. A key hallmark AD the irreversible overaccumulation beta-amyloid (Aβ) in brain, associated with neuroinflammation neuronal death. Although Aβ clearance immunoregulation have been major therapeutic strategies for AD, highly selective transport across blood–brain barrier (BBB) negatively affects delivery efficacy drugs without ability to cross BBB. In this review, we discuss potential lipid-based nanoparticles (LBNs) as promising vehicles drug treatment. LBNs, composed phospholipid mono- or bilayer, attracted attention due their exceptional cellular penetration capabilities loading capabilities, which also facilitate cargo transcytosis Recent advances development engineering LBNs overcome existing limitations current clinical approaches treatment addressing off-target effects low efficacy. Here, review pathways BBB, well various types therapy, including exosomes, liposomes, solid lipid (SLNs), nanostructured carriers (NLCs), elucidate properties, preparation methodologies, efficacy, thereby offering innovative avenues novel translation therapy.

Язык: Английский

---

Nanomedicine in Lung Cancer Immunotherapy

Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11

Опубликована: Март 17, 2023

Lung cancer is the major cause of death worldwide. Cancer immunotherapy has been introduced as a promising and effective treatment that can improve immune system’s ability to eliminate cells help establish immunological memory. Nanoparticles contribute rapidly evolving field by simultaneously delivering variety agents target site tumor microenvironment. Nano drug delivery systems precisely biological pathways be implemented reprogram or regulate responses. Numerous investigations have conducted employ different types nanoparticles for lung cancer. Nano-based adds strong tool diverse collection therapies. This review briefly summarizes remarkable potential opportunities in its challenges.

Язык: Английский

---

Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: From mechanisms to therapy

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 163, С. 114817 - 114817

Опубликована: Май 2, 2023

Cardiovascular and cerebrovascular diseases (CVDs) remain an intractable problem have high morbidity mortality worldwide, as well substantial health economic burdens, representing urgent clinical need. In recent years, the focus of research has shifted from use mesenchymal stem cells (MSCs) for transplantation to their secretory exosomes (MSC-exosomes) treatment numerous CVDs, including atherosclerosis, myocardial infarction (MI), heart failure (HF), ischemia/reperfusion (I/R), aneurysm, stroke. MSCs are pluripotent with multiple differentiation pathways that exert pleiotropic effects by producing soluble factors, most effective components which exosomes. MSC-exosomes considered be excellent promising cell-free therapy CVDs due higher circulating stability, improved biocompatibility, reduced toxicity, immunogenicity. addition, play critical roles in repairing inhibiting apoptosis, regulating inflammation, ameliorating cardiac remodeling, promoting angiogenesis. Herein, we describe knowledge about biological characteristics MSC-exosomes, investigate mechanism mediate therapeutic repair, summarize advances efficacy a view toward future applications.

Язык: Английский

---

Therapeutic and Diagnostic Potential of Exosomes as Drug Delivery Systems in Brain Cancer

Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1439 - 1439

Опубликована: Май 8, 2023

Cancer is designated as one of the principal causes mortality universally. Among different types cancer, brain cancer remains most challenging due to its aggressiveness, ineffective permeation ability drugs through blood–brain barrier (BBB), and drug resistance. To overcome aforementioned issues in fighting there an imperative need for designing novel therapeutic approaches. Exosomes have been proposed prospective “Trojan horse” nanocarriers anticancer theranostics owing their biocompatibility, increased stability, permeability, negligible immunogenicity, prolonged circulation time, high loading capacity. This review provides a comprehensive discussion on biological properties, physicochemical characteristics, isolation methods, biogenesis internalization exosomes, while it emphasizes diagnostic potential vehicle systems highlighting recent advances research field. A comparison activity effectiveness several exosome-encapsulated cargo including biomacromolecules underlines great supremacy over non-exosomal encapsulated delivery, accumulation, potency. Various studies cell lines animals give prominence exosome-based nanoparticles (NPs) promising alternative approach management cancer.

Язык: Английский

---

Nano based-oncolytic viruses for cancer therapy

Critical Reviews in Oncology/Hematology, Год журнала: 2023, Номер 185, С. 103980 - 103980

Опубликована: Март 29, 2023

Язык: Английский

---

Mesenchymal Stem Cell (MSC)-Based Drug Delivery into the Brain across the Blood–Brain Barrier

Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 289 - 289

Опубликована: Фев. 18, 2024

At present, stem cell-based therapies using induced pluripotent cells (iPSCs) or mesenchymal (MSCs) are being used to explore the potential for regenerative medicine in treatment of various diseases, owing their ability multilineage differentiation. Interestingly, MSCs employed not only medicine, but also as carriers drug delivery, homing target sites injured damaged tissues including brain by crossing blood–brain barrier (BBB). In research and development, membrane impermeability is a serious problem. The development central nervous system drugs neurodegenerative such Alzheimer’s disease Parkinson’s disease, remains difficult due capillary endothelial at BBB, addition complicated pathogenesis pathology. Thus, intravenously intraarterially administered MSC-mediated delivery non-invasive way solution this transendothelial problem BBB. Substances delivered divided into artificially included materials advance, low molecular weight compounds doxorubicin, expected protein expression products genetic modification, interleukins. After internalizing through fenestration between cells, release cargos cells. review, I introduce advantages across BBB carrier that moves if they acted own will.

Язык: Английский

---

Mesenchymal Stem Cells-Derived Exosomes Alleviate Acute Lung Injury by Inhibiting Alveolar Macrophage Pyroptosis

Stem Cells Translational Medicine, Год журнала: 2024, Номер 13(4), С. 371 - 386

Опубликована: Фев. 13, 2024

Abstract Acute lung injury (ALI) is an important pathological process of acute respiratory distress syndrome, yet there are limited therapies for its treatment. Mesenchymal stem cells-derived exosomes (MSCs-Exo) have been shown to be effective in suppressing inflammation. However, the effects MSCs-Exo on ALI and underlying mechanisms not well elucidated. Our data showed that MSCs-Exo, but derived from MRC-5 cells (MRC-5-Exo), which human fetal fibroblast cells, significantly improved chest imaging, histological observations, alveolocapillary membrane permeability, reduced inflammatory response mice model. According miRNA sequencing proteomic analysis MRC-5-Exo, may inhibit pyroptosis by miRNAs targeting caspase-1-mediated pathway, proteins with immunoregulation functions. Taken together, our study demonstrated were treating inhibiting alveolar macrophages reducing inflammation response. Its mechanism through pyroptosis-targeting immunoregulating delivered MSCs-Exo. Therefore, a new treatment option early stage ALI.

Язык: Английский

---