Efficacy and safety of mesenchymal stem cell therapy in acute on chronic liver failure: a systematic review and meta-analysis of randomized controlled clinical trials

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 20, 2025

Acute-on-chronic liver failure has become a serious global health burden, which is characterized by an acute deterioration of function, rapidly evolving organ failure, and high short-term mortality in patients with chronic disease. The pathogenesis includes extensive hepatic necrosis, related to intense systemic inflammation subsequently causes the inflammatory cytokine storm, resulting portal hypertension, dysfunction, failure. Mesenchymal stem cells can function as seed remodel repair damaged tissues, thus showing potential therapeutic alternatives for However, standard treatment protocols mesenchymal acute-on-chronic have not been established. We conducted detailed search from PubMed/Medline, Web Science, EMBASE, Cochrane Library find randomized controlled trials published before October 23, 2021. formulated criteria literature screening according PICOS principle (Population, Intervention, Comparison, Outcome, Study design). Subsequently, bias risk assessment tool was used assess quality all enrolled studies. Finally, outcome measurements including model end-stage disease score, albumin, total bilirubin, coagulation aminotransferase were extracted statistical analysis. A 7 clinical included. results studies indicated that who received inoculation showed decreased MELD score 4 weeks 24 weeks, compared counterparts conventional treatment. Reciprocally, improved ALB levels weeks. For secondary indicators, significantly reduced INR ALT levels, control group. Our no significant differences incidence adverse reactions or events monitored after inoculation. This meta-analysis cell infusion effective safe Without increasing events, MSC decrease increase large-cohort longer follow-up periods are required further confirm our conclusions.

Язык: Английский

---

Efficacy and safety of mesenchymal stem cells therapy in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Июнь 8, 2024

Abstract Background The coronavirus disease 2019 (COVID-19) has become a serious public health issue. In COVID-19 patients, the elevated levels of inflammatory cytokines lead to manifestation symptoms, such as lung tissue edema, diffusion dysfunction, acute respiratory distress syndrome (ARDS), secondary infection, and ultimately mortality. Mesenchymal stem cells (MSCs) exhibit anti-inflammatory immunomodulatory properties, thus providing potential treatment option for COVID-19. number clinical trials MSCs been rising. However, protocols therapeutic effects patients are inconsistent. This meta-analysis was performed systematically determine safety efficacy MSC infusion in patients. Methods We conducted comprehensive literature search from PubMed/Medline, Web Science, EMBASE, Cochrane Library up 22 November 2023 screen eligible randomized controlled trials. Inclusion exclusion criteria searched were formulated according PICOS principle, followed by use quality assessment tools assess risk bias. Finally, outcome measurements including efficacy, adverse events each study extracted statistical analysis. Results A total 14 collected. results enrolled studies demonstrated that with pneumonia who received inoculation showed decreased mortality compared counterparts conventional (RR: 0.76; 95% CI [0.60, 0.96]; p = 0.02). Reciprocally, improved symptoms 1.28; [1.06, 1.55]; 0.009). terms immune biomarkers, inhibited inflammation responses indicated CRP IL-6. Importantly, our no significant differences incidence reactions or monitored after inoculation. Conclusion is effective safe pneumonia. Without increasing events, patient large-cohort expanded numbers required further confirm results.

Язык: Английский

---

Efficacy of stem cell therapy in patients with chronic liver disease: an umbrella review of systematic reviews

International Journal of Surgery, Год журнала: 2024, Номер 110(11), С. 6848 - 6861

Опубликована: Май 22, 2024

Background: Stem cell therapy offers promising benefits like modulating immune responses, reducing inflammation, and aiding liver regeneration. This umbrella review seeks to compile evidence from systematic reviews assess the efficacy of stem for improving function survival rates in chronic disease patients. Methods: We searched electronic databases up February 15, 2024. The selection process focused on comparing with standard care or a placebo. primary outcomes evaluated were changes enzymes, Model End-Stage Liver Disease score, rates. Nested Knowledge software was utilized screening data extraction. All statistical analyses performed using R software, version 4.3. Results: Our included 28 reviews. meta-analysis showcased notable improvement pooled relative risk 1.487 [95% confidence interval (CI): 1.281–1.727). In nonrandomized studies, albumin levels exhibited standardized mean difference (SMD) 0.786 (95% CI: 0.368–1.204), indicating positive therapeutic effects. For alanine aminotransferase, revealed decrease an SMD −0.499 −0.834 −0.164), aspartate overall −0.362 −0.659 −0.066) observed, suggesting hepatoprotective No significant observed total bilirubin scores randomized controlled trials. Conclusion: exhibits potential as novel treatment diseases, it has demonstrated improvements certain markers. More high-quality trials are needed future fully ascertain this patient population.

Язык: Английский

---

Validity of stem cell-loaded scaffolds to facilitate endometrial regeneration and restore fertility: a systematic review and meta-analysis

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Май 23, 2024

Objective Various stem cell-loaded scaffolds have demonstrated promising endometrial regeneration and fertility restoration. This study aimed to evaluate the efficacy of in treating uterine injury animal models. Methods The PubMed, Embase, Scopus, Web Science databases were systematically searched. Data extracted analyzed using Review Manager version 5.4. Improvements thickness, glands, fibrotic area, number gestational sacs/implanted embryos compared after transplantation scaffold-only group. standardized mean difference (SMD) confidence interval (CI) calculated forest plots. Results Thirteen studies qualified for meta-analysis. Overall, scaffold groups, significantly increased thickness (SMD = 1.99, 95% CI: 1.54 2.44, P < 0.00001; I² 16%) glands 1.93, 1.45 2.41, 0). Moreover, present a prominent effect on improving fibrosis area −2.50, –3.07 –1.93, 36%) 3.34, 1.58 5.09, 0.0002; 83%). Significant heterogeneity among was observed, further subgroup sensitivity analyses identified source heterogeneity. exhibited lower inflammation levels higher angiogenesis, cell proliferation transplantation. Conclusion evidence indicates that more effective promoting repair restoring than groups. limitations small sample sizes should be considered when interpreting results. Thus, larger clinical trials are needed investigation. Systematic review registration https://www.crd.york.ac.uk/PROSPERO , identifier CRD42024493132.

Язык: Английский

---

Effectiveness and mechanisms of mesenchymal stem cell therapy in preclinical animal models of hepatic fibrosis: a systematic review and meta-analysis

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Июль 22, 2024

Liver damage due to long-term viral infection, alcohol consumption, autoimmune decline, and other factors could lead the gradual development of liver fibrosis. Unfortunately, until now, there has been no effective treatment for Mesenchymal stem cells, as a promising new therapy fibrosis, can slow progression fibrosis by migrating site injury altering microenvironment fibrotic area.

Язык: Английский

---

Cell therapy for end-stage liver disease: Current state and clinical challenge

Chinese Medical Journal, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Liver disease involves a complex interplay of pathological processes, including inflammation, hepatocyte necrosis, and fibrosis. End-stage liver (ESLD), such as failure decompensated cirrhosis, has high mortality rate, transplantation is the only effective treatment. However, to overcome problems shortage donor livers complications related immunosuppression, there an urgent need for new treatment strategies that be developed patients with ESLD. For instance, hepatocytes derived from or stem cells can engrafted multiplied in liver, substituting host rebuilding parenchyma. Stem cell therapy, especially mesenchymal been widely proved restore function alleviate injury severe disease, which contributed clinical application therapy. In this review, we discussed types used treat ESLD their therapeutic mechanisms. We also summarized progress trials around world provided perspective on

Язык: Английский

---

Application of mesenchymal stem cells in liver fibrosis and regeneration

Liver Research, Год журнала: 2024, Номер 8(4), С. 246 - 258

Опубликована: Ноя. 26, 2024

Язык: Английский

---

Advances in Mesenchymal Stem Cell Therapy and Natural Antioxidants for Hepatic Fibrosis: A Comprehensive Review

Deleted Journal, Год журнала: 2024, Номер 2, С. 100016 - 100016

Опубликована: Март 1, 2024

Liver damage resulting from the administration of various allopathic drugs and their associated toxicity has become a major health problem, leading to hepatic fibrosis, cirrhosis, metabolic disorders. This epidemic condition liver disease represents global cause death morbidity. Although orthotopic transplantation remains vital treatment option for fibrotic conditions, its efficacy is limited by organ scarcity risk immunological rejection. Consequently, alternative therapeutic approaches are urgently needed. Cell-based therapy utilizing mesenchymal stem cells (MSCs) garnered considerable interest as promising modality. MSCs exhibit immunomodulatory properties can differentiate into hepatocytes, thus facilitating regeneration damaged hepatocytes increasing residual hepatocyte proliferation while inhibiting activation or apoptosis stellate cells. However, despite potential benefits, transplanted often low survival rates due inadequate oxidative inflammatory stress resistance. Plants harbor diverse array bioactive compounds known possess hepatoprotective antioxidant properties. Nanomaterials play crucial role in regenerative medicine providing targeted delivery agents scaffolds tissue engineering. In treating liver, nanomaterials help mitigate fibrosis progression promote through controlled release anti-fibrotic growth factors. review highlights synergistic cell-based therapy, natural antioxidants, differentiation factors, nanotechnology combating advancing medicine. These combined offer avenues effectively conditions promoting regeneration.

Язык: Английский

---

Use of Mesenchymal Stem Cell Transplantation as a Treatment for Liver Cirrhosis in Animal Models

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Окт. 17, 2024

Liver cirrhosis is one of the top 10 causes death worldwide, and liver disease in five many developing countries. The treatment at various stages necessitates development new organ transplantation techniques. One these options cell therapy, which has lately been used to treat a wide range illnesses.

Язык: Английский

---

Hepatic encephalopathy: experimental drugs in development and therapeutic potential

Expert Opinion on Investigational Drugs, Год журнала: 2024, Номер unknown, С. 1 - 12

Опубликована: Ноя. 26, 2024

Hepatic encephalopathy (HE) presents a complex pathophysiology, creating multiple potential treatment avenues. This review covers current and emerging treatments for HE.

Язык: Английский

---