Oxidative Stress and Age-Related Tumors

Antioxidants, Год журнала: 2024, Номер 13(9), С. 1109 - 1109

Опубликована: Сен. 13, 2024

Oxidative stress is the result of imbalance between reactive oxygen and nitrogen species (RONS), which are produced by several endogenous exogenous processes, antioxidant defenses consisting molecules that protect biological systems from free radical toxicity. a major factor in aging process, contributing to accumulation cellular damage over time. biomolecules, leads DNA alterations, lipid peroxidation, protein oxidation, mitochondrial dysfunction resulting senescence, immune system tissue dysfunctions, increased susceptibility age-related pathologies, such as inflammatory disorders, cardiovascular neurodegenerative diseases, diabetes, cancer. stress-driven mutations, or methylation histone modification, alter gene expression, key determinants tumor initiation, angiogenesis, metastasis, therapy resistance. Accumulation genetic epigenetic damage, oxidative contributes, eventually unrestrained cell proliferation, inhibition differentiation, evasion death, providing favorable conditions for tumorigenesis. Colorectal, breast, lung, prostate, skin cancers most frequent aging-associated malignancies, implicated their pathogenesis behavior. Our aim shed light on molecular mechanisms link stress, aging, cancers, highlighting impact both RONS antioxidants, provided diet exercise, immunity, development an antitumor response. The dual role ROS physiological regulators signaling responsible well its use anti-tumor therapeutic purposes, will also be discussed. Managing crucial promoting healthy reducing risk tumors.

Язык: Английский

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Clinical impact of epithelial–mesenchymal transition for cancer therapy

Clinical and Translational Discovery, Год журнала: 2024, Номер 4(1)

Опубликована: Янв. 28, 2024

Abstract The epithelial–mesenchymal transition (EMT) represents a pivotal frontier in oncology, playing central role the metastatic cascade of cancer—a leading global health challenge. This comprehensive review delves into complexities EMT, process where cancer cells gain exceptional mobility, facilitating their invasion distant organs and establishment secondary malignancies. We thoroughly examine myriad factors influencing encompassing transcription factors, signalling pathways, metabolic alterations, microRNAs, long non‐coding RNAs, epigenetic changes, exosomal interactions intricate dynamics tumour microenvironment. Particularly, emphasises advanced stages crucial for development highly aggressive phenotypes. During this phase, penetrate vascular barrier exploit bloodstream to propagate life‐threatening metastases through mesenchymal–epithelial transition. also explore EMT's significant fostering dormancy, senescence, emergence stem formidable challenge therapeutic resistance. Our transcends mere inventory EMT‐inducing elements; it critically assesses current state EMT‐focused clinical trials, revealing both hurdles breakthroughs. Highlighting potential EMT research, we project its transformative impact on future therapy. exploration is aimed at paving way towards an era effectively managing relentless disease, positioning forefront innovative research strategies.

Язык: Английский

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Recent advances in targeting cancer stem cells by using nanomaterials

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125381 - 125381

Опубликована: Фев. 1, 2025

Язык: Английский

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Epithelial–mesenchymal transition to Mitigate Age-Related Progression in Lung Cancer

Ageing Research Reviews, Год журнала: 2024, Номер 102, С. 102576 - 102576

Опубликована: Ноя. 7, 2024

Язык: Английский

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Breast Cancer Stem Cell Heterogeneity, Plasticity and Treatment Strategies

Опубликована: Март 6, 2025

Breast cancer stem cells (BCSCs) are a small proportion of stem-like breast with more tumorigenic and metastatic capacity in comparison to the bulk tumor cells, which capable self-renewal generating differentiated cells. BCSCs resistant chemotherapy radiotherapy. More research indicate that heterogeneous have plasticity, refer their ability switch between different subtypes There is some evidence showing BCSC heterogeneity plasticity plays role on therapeutic resistance metastasis cancer. In this review, we discussed roles extrinsic (rewired microenvironment, including hypoxia, microbiota) intrinsic (pro-tumor signaling) factors regulating leading various malignant behaviors BCSCs, epithelial-mesenchymal transition (EMT)/mesenchymal-epithelial (MET), immune evasion, vasculogenesis so on. Moreover, also potential strategies target BCSCs.

Язык: Английский

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An in- vitro measurement for the toxicity of peptides inhibit hexokinase II in breast cancer cell lines

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 27, 2025

The role of the enzyme hexokinase 2 in many cancers has been identified through increased glycolysis or binding to pro-apoptotic channel located outer mitochondrial membrane, (VDCA1) and protein kinase (MTOR). To prevent cancer-causing pathways this enzyme, it is possible disrupt interaction subunits. Peptides can be utilized interfere with subunits by amino acids that contribute dimerization. Nowadays, peptides have become a suitable option for treatment various diseases, especially cancer, due their small size, ease synthesis, ability penetrate tumor. This study examined toxic effect inhibit on tumorigenic MCF-7 MDA-MB-231 non-tumorigenic MCF10A cell lines MTT analysis flow cytometry determine apoptosis. line experienced significant decrease proliferation both peptides. RYALFSS peptide caused number cells, but EKGLGATTHPTAAVKML increase. There was no increase line. study's finding indicate serve as tool carcinogenic cells.

Язык: Английский

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Mechanistic studies and therapeutic potential of angiopoietin in head and neck tumor angiogenesis

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Апрель 7, 2025

Head and neck tumors represent a prevalent category of oral maxillofacial malignancies, posing significant therapeutic prognostic challenges due to their complex anatomical structure, tumor heterogeneity, resistance conventional therapies. Recent studies have highlighted the strong association between progression neoangiogenesis, with angiopoietin (ANG) family playing central role in this process. Comprising ANG1, ANG2, ANG3, ANG4, these factors regulate multiple signaling pathways that promote cellular growth, differentiation, proliferation, thereby driving angiogenesis accelerating growth metastasis. Therefore, comprehensive investigation ANG family's head may offer critical insights into tumorigenesis mechanisms unveil novel targets. Such research has potential improve treatment outcomes enhance quality life for patients.

Язык: Английский

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MiRNA Dysregulation in Brain Injury: An In Silico Study to Clarify the Role of a MiRNA Set

Current Neuropharmacology, Год журнала: 2024, Номер 23(2), С. 209 - 231

Опубликована: Авг. 12, 2024

The identification of specific circulating miRNAs has been proposed as a valuable tool for elucidating the pathophysiology brain damage or injury and predicting patient outcomes.

Язык: Английский

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Residual OXPHOS is required to drive primary and metastatic lung tumours in an orthotopic breast cancer model

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Май 1, 2024

Background Fast adaptation of glycolytic and mitochondrial energy pathways to changes in the tumour microenvironment is a hallmark cancer. Purely ρ 0 cells do not form primary tumours unless they acquire healthy mitochondria from their micro-environment. Here we explored effects severely compromised respiration on metastatic capability 4T1 mouse breast cancer cells. Methods cell lines with different levels respiratory capacity were generated; Seahorse extracellular flux analyser was used evaluate oxygen consumption rates, fluorescent confocal microscopy assess number SYBR gold-stained DNA nucleoids, presence ATP5B protein cytoplasm situ nuclear hybridization establish ploidy. MinION nanopore RNA sequence analysis compare transcription between lines. Orthotopic injection determine ability metastasize lungs female Balb/c mice. Results OXPHOS-deficient ATP5B-KO3.1 did generate tumours. Severely OXPHOS D5 generated both lung metastases. Cells metastasis OXPHOS-competent OXPHOS-compromised formed but no metastases when re-injected into significantly increased mtDNA content, this result capacity, which due decreased transcription. Gene set enrichment suggests that certain derived downregulate epithelial-to-mesenchymal related pathways. Conclusion In summary, required for tumorigenesis orthotopic model even very low are sufficient

Язык: Английский

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Regulation of cellular and molecular markers of epithelial-mesenchymal transition by Brazilin in breast cancer cells

PeerJ, Год журнала: 2024, Номер 12, С. e17360 - e17360

Опубликована: Май 9, 2024

Breast cancer is the most common invasive neoplasm and leading cause of death in women worldwide. The main mortality patients invasion metastasis, where epithelial-mesenchymal transition (EMT) a crucial player these processes. Pharmacological therapy has plants as its primary source, including isoflavonoids. Brazilin an isoflavonoid isolated from

Язык: Английский

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