Deleted Journal,
Год журнала:
2024,
Номер
3(2), С. 113 - 119
Опубликована: Дек. 30, 2024
This
review
was
to
describe
the
state
and
progress
regarding
methods
for
3D
bioprinting
applicable
corneal
regeneration;
these
are
identified
with
developments
related
bioink
technologies.
article
has
pointed
out
in
detail
mechanism
of
printing
process;
it
maintains
that
ideally
consists
biomaterial
components
deriving
both
from
natural
synthetic
ones,
cells,
biochemical
factors,
such
ways
which
could
imitate
properties
a
native
cornea
several
respects,
its
mechanic,
structural,
ultrastructural
features.
Biocompatibility,
transparency,
strength
tension,
corresponding
rheology
were
emphasized
as
relevant.
discusses
recent
modalities
bioprinting,
including
inkjet,
extrusion-based,
laser-assisted
stereolithography,
their
adequacy
tissue
engineering.
The
integrated
use
advanced
techniques
combined
optimized
bioinks
is
highly
promising
approach
fabrication
functional
tissues
restored
vision
treatment
ocular
disorders.
npj Regenerative Medicine,
Год журнала:
2025,
Номер
10(1)
Опубликована: Фев. 14, 2025
Abstract
Corneal
diseases
are
the
third
leading
cause
of
blindness
worldwide.
Descemet’s
Membrane
Endothelial
Keratoplasty
(DMEK)
is
preferred
surgical
technique
for
treating
corneal
endothelial
disorders,
relying
heavily
on
high-quality
donor
tissue.
However,
scarcity
suitable
tissue
and
sensitivity
cells
remain
significant
challenges.
This
review
explores
current
state
DMEK,
focusing
advancements
in
engineering
as
a
promising
solution
to
improve
outcomes
address
limitations.
Bioengineering,
Год журнала:
2024,
Номер
11(8), С. 777 - 777
Опубликована: Июль 31, 2024
Since
three-dimensional
(3D)
bioprinting
has
emerged,
it
continuously
to
evolved
as
a
revolutionary
technology
in
surgery,
offering
new
paradigms
for
reconstructive
and
regenerative
medical
applications.
This
review
highlights
the
integration
of
3D
printing,
specifically
bioprinting,
across
several
surgical
disciplines
over
last
five
years.
The
methods
employed
encompass
recent
literature
focusing
on
innovations
applications
3D-bioprinted
tissues
and/or
organs.
findings
reveal
significant
advances
creation
complex,
customized,
multi-tissue
constructs
that
mimic
natural
tissue
characteristics,
which
are
crucial
interventions
patient-specific
treatments.
Despite
technological
advances,
paper
introduces
discusses
challenges
remain,
such
vascularization
bioprinted
tissues,
with
host
tissue,
long-term
viability
concludes
while
holds
substantial
promise
transforming
practices
enhancing
patient
outcomes,
ongoing
research,
development,
clear
regulatory
framework
essential
fully
realize
potential
future
clinical
Biomaterials Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Biomaterial-based
strategies,
including
ECM
coatings
and
functionalized
polymers,
enable
efficient
expansion
of
primary
human
corneal
endothelial
cells,
addressing
donor
shortages
advancing
cell
therapy
for
transplantation.
Journal of Clinical & Translational Ophthalmology,
Год журнала:
2025,
Номер
3(2), С. 6 - 6
Опубликована: Март 26, 2025
Over
2.2
billion
people
across
the
globe
face
significant
barriers
to
accessing
essential
ophthalmic
care,
with
elderly,
rural,
and
refugee
populations
being
disproportionately
affected,
deepening
existing
disparities
in
eye
care.
Three-dimensional
printing
is
a
novel
technology
that
has
potential
transform
field
improve
access
by
alleviating
many
patient-specific
barriers.
This
article
delves
into
evolution
of
3D
within
ophthalmology,
highlighting
its
current
applications
future
potential.
It
explores
various
techniques
numerous
biomaterials
discussing
their
effectiveness
creating
advanced
solutions
such
as
bioengineered
corneas,
ocular
prosthetics,
innovative
treatments
for
dry
syndrome,
from
punctal
plugs
lacrimal
gland
models.
Additionally,
revolutionized
drug
delivery
systems
conditions
like
glaucoma,
retinal
diseases,
brachytherapy.
Whether
through
printed
contact
lens-based
or
polycaprolactone
implants
biodegrade
provide
sustained
release
without
adverse
effects,
these
hold
immense
field.
Despite
promise,
integration
clinical
practice
presents
challenges,
which
addresses
alongside
strategies
overcoming
them.
By
mapping
out
technological
advancements
this
review
offers
roadmap
enhancing
global
care
accessibility
improving
patient
outcomes
on
scale.
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(4), С. 118 - 118
Опубликована: Март 28, 2025
Corneal
transplantation
remains
a
critical
treatment
option
for
individuals
with
corneal
disorders,
but
it
faces
challenges
such
as
rejection,
high
associated
medical
costs,
and
donor
scarcity.
A
promising
alternative
replacement
involves
fabricating
artificial
cornea
from
patient's
own
cells.
Our
study
aimed
to
leverage
bioprinting
develop
model
using
human
stromal
cells
embedded
in
collagen-based
bioink.
We
generated
both
cellular
acellular
collagen
I
(COL
I)
constructs.
Cellular
constructs
were
cultured
up
4
weeks,
gene
expression
analysis
was
performed
assess
extracellular
matrix
(ECM)
remodeling
fibrotic
markers.
results
demonstrated
significant
decrease
the
of
COL
I,
III
III),
vimentin
(VIM),
vinculin
(VCL),
indicating
dynamic
process
towards
more
physiologically
relevant
ECM.
Overall,
our
provides
foundational
framework
developing
customizable,
replacements
technology.
Further
research
is
necessary
optimize
bioink
composition
evaluate
functional
biomechanical
properties
these
bioengineered
corneas.
Polymers,
Год журнала:
2024,
Номер
16(20), С. 2882 - 2882
Опубликована: Окт. 12, 2024
Corneal
endothelial
dysfunction
is
a
leading
cause
of
vision
loss
globally,
frequently
requiring
corneal
transplantation.
However,
the
limited
availability
donor
tissues,
particularly
in
developing
countries,
has
spurred
on
exploration
tissue
engineering
strategies,
with
focus
polymer
biomaterials
as
scaffolds
for
endotlhelium
regeneration.
This
review
provides
comprehensive
overview
advancements
biomaterials,
focusing
their
role
supporting
growth,
differentiation,
and
functional
maintenance
human
cells
(CECs).
Key
properties
scaffold
materials,
including
optical
clarity,
biocompatibility,
biodegradability,
mechanical
stability,
permeability,
surface
wettability,
are
discussed
detail.
The
also
explores
latest
innovations
micro-
nano-topological
morphologies,
fabrication
techniques
such
electrospinning
3D/4D
bioprinting,
integration
drug
delivery
systems
into
scaffolds.
Despite
significant
progress,
challenges
remain
translating
these
technologies
to
clinical
applications.
Future
directions
research
highlighted,
need
improved
biomaterial
combinations,
deeper
understanding
CEC
biology,
development
scalable
manufacturing
processes.
aims
serve
resource
researchers
clinician–scientists
seeking
advance
field
endothelium
engineering.
Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine,
Год журнала:
2024,
Номер
238(10), С. 939 - 963
Опубликована: Окт. 1, 2024
Additive
Manufacturing
(AM)
encompasses
various
techniques
creating
intricate
components
from
digital
models.
The
aim
of
incorporating
3D
printing
(3DP)
in
the
healthcare
sector
is
to
transform
patient
care
by
providing
personalized
solutions,
improving
medical
procedures,
fostering
research
and
development,
ultimately
optimizing
efficiency
effectiveness
delivery.
This
review
delves
into
historical
beginnings
AM’s
9
integration
contexts
exploring
categories
AM
methodologies
their
roles
within
sector.
survey
also
dives
issue
material
requirements
challenges
specific
applications.
Emphasis
placed
on
how
processes
directly
enhance
human
well-being.
primary
focus
this
paper
highlight
evolution
incentives
for
cross-disciplinary
applications,
particularly
realm
considering
principle,
materials
It
designed
a
diverse
audience,
including
manufacturing
professionals
researchers,
seeking
insights
transformative
technology’s
dimensions.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 13, 2024
The
cornea
acts
as
the
eye
foremost
protective
layer
and
is
essential
for
its
focusing
power.
Corneal
blindness
may
arise
from
physical
trauma
or
conditions
like
dystrophies,
keratitis,
keratoconus,
ulceration.
While
conventional
treatments
involve
medical
therapies
donor
allografts—sometimes
supplemented
with
keratoprostheses—these
options
are
not
suitable
all
corneal
defects.
Consequently,
development
of
bioartificial
tissue
has
emerged
a
critical
research
area,
aiming
to
address
global
shortage
human
donors.
Bioengineered
corneas
hold
considerable
promise
substitutes,
potential
replace
either
specific
layers
entire
thickness
damaged
corneas.
This
review
first
delves
into
structural
anatomy
cornea,
identifying
key
attributes
necessary
successful
bioengineering.
It
then
examines
various
pathologies,
current
treatments,
their
limitations.
Finally,
outlines
primary
approaches
in
engineering,
exploring
cell-free,
cell-based,
scaffold-based
three
emerging
strategies
failure.
Over
2.2
billion
people
across
the
globe
face
significant
barriers
to
accessing
essential
ophthalmic
care,
with
elderly,
rural,
and
refugee
populations
being
disproportionately
affected.
These
obsta-cles
deepen
existing
disparities
in
eye
care.
3D
printing
is
a
novel
technology
that
has
potential
transform
field
improve
access
through
alleviating
many
patient-specific
barriers.
This
article
delves
into
evolution
of
within
ophthalmology,
highlighting
its
current
ap-plications
future
potential.
It
explores
various
techniques
biomaterials,
dis-cussing
their
effectiveness
creating
advanced
solutions
such
as
bioengineered
corneas,
ocular
prosthetics,
innovative
treatments
for
dry
syndrome.
Additionally,
rev-olutionized
drug
delivery
systems
conditions
like
glaucoma,
retinal
diseases,
brachytherapy.
Despite
promise,
integration
clinical
practice
presents
challenges,
which
addresses
alongside
strategies
overcoming
them.
By
mapping
out
technological
advancements
this
review
offers
roadmap
enhancing
global
care
accessibility
improving
patient
outcomes
on
scale.
