Cisplatin-eugenol Pt(IV) prodrugs target colon cancer stem cells: A novel strategy for enhanced anticancer efficacy
Biomedicine & Pharmacotherapy,
Год журнала:
2025,
Номер
183, С. 117854 - 117854
Опубликована: Янв. 18, 2025
Язык: Английский
Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicine
MedComm,
Год журнала:
2024,
Номер
5(10)
Опубликована: Сен. 21, 2024
Organoids
are
miniature,
highly
accurate
representations
of
organs
that
capture
the
structure
and
unique
functions
specific
organs.
Although
field
organoids
has
experienced
exponential
growth,
driven
by
advances
in
artificial
intelligence,
gene
editing,
bioinstrumentation,
a
comprehensive
overview
organoid
applications
remains
necessary.
This
review
offers
detailed
exploration
historical
origins
characteristics
various
types,
their
applications-including
disease
modeling,
drug
toxicity
efficacy
assessments,
precision
medicine,
regenerative
medicine-as
well
as
current
challenges
future
directions
research.
have
proven
instrumental
elucidating
genetic
cell
fate
hereditary
diseases,
infectious
metabolic
disorders,
malignancies,
study
processes
such
embryonic
development,
molecular
mechanisms,
host-microbe
interactions.
Furthermore,
integration
technology
with
intelligence
microfluidics
significantly
advanced
large-scale,
rapid,
cost-effective
thereby
propelling
progress
medicine.
Finally,
advent
high-performance
materials,
three-dimensional
printing
technology,
also
gaining
prominence
Our
insights
predictions
aim
to
provide
valuable
guidance
researchers
support
continued
advancement
this
rapidly
developing
field.
Язык: Английский
CXCR3 inhibition ameliorates mitochondrial function to restrict oxidative damage via NCOA4-mediated ferritinophagy and improves the gut microbiota in mice
Free Radical Biology and Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Advances in the Development and Application of Human Organoids: Techniques, Applications, and Future Perspectives
Cell Transplantation,
Год журнала:
2025,
Номер
34
Опубликована: Янв. 1, 2025
Organoids
are
three-dimensional
(3D)
cell
cultures
derived
from
human
pluripotent
stem
cells
or
adult
that
recapitulate
the
cellular
heterogeneity,
structure,
and
function
of
organs.
These
microstructures
invaluable
for
biomedical
research
due
to
their
ability
closely
mimic
complexity
native
tissues
while
retaining
genetic
material.
This
fidelity
organ
systems
positions
organoids
as
a
powerful
tool
advancing
our
understanding
biology
enhancing
preclinical
drug
testing.
Recent
advancements
have
led
successful
development
variety
organoid
types,
reflecting
broad
range
organs
tissues.
progress
has
expanded
application
across
several
domains,
including
regenerative
medicine,
where
offer
potential
tissue
replacement
repair;
disease
modeling,
which
allows
study
mechanisms
progression
in
controlled
environment;
discovery
evaluation,
provide
more
accurate
platform
testing
efficacy
safety;
microecological
research,
they
contribute
interactions
between
microbes
host
review
provides
comprehensive
overview
historical
technology,
highlights
key
achievements
ongoing
challenges
field,
discusses
current
emerging
applications
both
laboratory
clinical
practice.
Язык: Английский
Colorectal Organoids: Models, Imaging, Omics, Therapy, Immunology, and Ethics
Cells,
Год журнала:
2025,
Номер
14(6), С. 457 - 457
Опубликована: Март 19, 2025
Colorectal
epithelium
was
the
first
long-term
3D
organoid
culture
established
in
vitro.
Identification
of
key
components
essential
for
survival
stem
cell
niche
allowed
an
indefinite
propagation
these
cultures
and
modulation
their
differentiation
into
various
lineages
mature
intestinal
epithelial
cells.
While
methods
were
eventually
adapted
to
establish
organoids
from
different
organs,
colorectal
remain
a
pioneering
model
development
new
applications
health
disease.
Several
basic
applicative
aspects
culture,
modeling,
monitoring
testing
are
analyzed
this
review.
We
also
tackle
ethical
problems
biobanking
distribution
precious
research
tools,
frequently
confined
laboratory
origin
or
condemned
destruction
at
end
project.
Язык: Английский
Potential Use of Organoids in Regenerative Medicine
Tissue Engineering and Regenerative Medicine,
Год журнала:
2024,
Номер
21(8), С. 1125 - 1139
Опубликована: Окт. 16, 2024
Язык: Английский
Interpretation of the past, present, and future of organoid technology: an updated bibliometric analysis from 2009 to 2024
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Авг. 13, 2024
Organoid
technology
has
been
developed
rapidly
in
the
past
decade,
which
involves
exploration
of
mechanism
development,
regeneration
and
various
diseases,
intersects
among
multiple
disciplines.
Thousands
literature
on
3D-culture
or
organoids
have
published
research
areas
cell
biology
tissue
engineering,
nanoscience,
oncology
so
on,
resulting
it
being
challenging
for
researchers
to
timely
summarize
these
studies.
Bibliometric
statistics
is
a
helpful
way
help
clarify
above
issues
efficiently
manage
whole
landscape
systematically.
In
our
study,
all
original
articles
were
included
Web
Science
database
from
January
2009
May
2024,
related
information
was
collected
analyzed
using
Excel
software,
“bibliometrix”
packages
R
VOSviewer
CiteSpace.
As
results,
total
6222
papers
classify
status
quo
predict
future
areas.
Our
findings
highlight
growing
trend
publications
organoids,
with
United
States
Netherlands
leading
this
field.
The
University
California
System,
Harvard
University,
Utrecht
Medical
Center
emerged
as
pivotal
contributors
key
authors
field
include
Clevers,
H,
Beekman,
JM
Spence
JR.
results
also
revealed
that
hotspots
trends
mainly
focused
clinical
treatment,
drug
screening,
application
materials
technologies
such
“hydrogel”
“microfluidic
technology”
organoids.
Next,
we
had
an
in-depth
interpretation
development
process
organoid
area,
including
emergence
technology,
translation
bench
bedsides,
profiles
most
widely
studied
types
technologies,
emerging
organoid-immune
co-cultures
trends.
Furthermore,
discussed
pitfalls,
challenges
prospects
technology.
conclusion,
study
provides
readers
straightforward
convenient
access
Язык: Английский
The Role of Gut Microbiome in Irritable Bowel Syndrome: Implications for Clinical Therapeutics
Yucui Zhao,
Shixiao Zhu,
Yingling Dong
и другие.
Biomolecules,
Год журнала:
2024,
Номер
14(12), С. 1643 - 1643
Опубликована: Дек. 21, 2024
Irritable
bowel
syndrome
(IBS)
is
a
functional
gastrointestinal
disorder
(FGID)
characterized
by
chronic
or
recurrent
symptoms
without
organic
changes,
and
it
also
common
of
gut–brain
interaction
(DGBIs)..
The
IBS
not
only
affect
the
quality
life
for
individual
patients
but
place
significant
burden
on
global
healthcare
systems.
lack
established
universally
applicable
biomarkers
IBS,
along
with
substantial
variability
in
progression,
presents
challenges
developing
effective
clinical
treatments.
In
recent
years,
preclinical
studies
have
linked
pathogenesis
to
alterations
composition
function
intestinal
microbiota.
Within
complex
microbial
community
gut,
intricate
metabolic
spatial
interactions
occur
among
its
members
between
microbes
their
hosts.
Amid
multifaceted
pathophysiology
role
microenvironment
factors
symptom
development
has
become
more
apparent.
This
review
aims
delve
into
changes
structure
gut
microbiome
individuals
IBS.
It
explores
how
diet-mediated
byproducts
play
regulating
influencing
“brain-gut”
axis,
barrier
function,
immune
responses,
more.
By
doing
so,
this
seeks
lay
theoretical
foundation
advancing
therapeutics
Язык: Английский