Опубликована: Янв. 14, 2025
Mid-life represents a pivotal period marked by profound physiological and metabolic transitions, increasing susceptibility to chronic diseases. This review explores the molecular systemic underpinnings of mid-life transition integrating insights from recent studies that elucidate aging-associated changes in plasma proteome, immune system, adipose tissue remodeling, cellular senescence. Nonlinear waves proteomic alterations have been identified as critical transitions inflammatory hormonal pathways. In addition, sex-specific aging trajectories linked adaptive immunity decline innate activation vulnerabilities mid-life. Moreover, tissue’s central role has established its early remodeling cytokine secretion drive stress. Furthermore, Glb1-2A-mCherry reporter introduced monitor aging, identifying crucial phase for cardiac hypertrophy senescence-induced inflammation. Collectively, these findings our understanding underscoring interplay between processes health, with emerging window intervention. also underscores biomarkers therapeutic strategies alleviate challenges mid-life, thereby promoting healthy aging.
Язык: Английский