Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 281 - 281
Опубликована: Фев. 20, 2025
The
blood–brain
barrier
(BBB)
is
a
critical
structure
that
maintains
brain
homeostasis
by
selectively
regulating
nutrient
influx
and
waste
efflux.
Not
surprisingly,
it
often
compromised
in
neurodegenerative
diseases.
In
addition
to
its
involvement
these
pathologies,
the
BBB
also
represents
significant
challenge
for
drug
delivery
into
central
nervous
system.
Nanoparticles
(NPs)
have
been
widely
explored
as
carriers
capable
of
overcoming
this
effectively
transporting
therapies
brain.
However,
their
potential
directly
address
ameliorate
dysfunction
has
received
limited
attention.
review,
we
examine
how
NPs
enhance
across
treat
diseases
explore
emerging
strategies
restore
integrity
vital
structure.
Язык: Английский
Advances in neural stem cells in aging and age-related neurodegenerative diseases
Ageing and Neurodegenerative Diseases,
Год журнала:
2025,
Номер
5(1)
Опубликована: Янв. 26, 2025
With
aging,
neural
stem
cells
(NSCs)
undergo
age-related
changes,
including
metabolic
abnormalities,
disrupted
protein
homeostasis,
mitochondrial
dysfunction,
reduced
genetic
stability,
and
more
notably,
a
diminished
capacity
for
proliferation
differentiation.
These
changes
may
contribute
to
the
development
of
neurodegenerative
diseases
such
as
Alzheimer’s
disease
(AD)
Parkinson’s
(PD).
In
these
conditions,
disease-specific
pathological
interact
with
alterations
NSCs,
resulting
in
impairment
neurogenesis,
which
further
leads
cognitive,
mood,
motor
decline.
Based
on
potential
therapeutics
targeting
neurogenesis
cell-based
therapies
restore
functions
NSCs
replace
degenerated
neurons,
aiming
ameliorate
functional
decline
diseases.
While
therapies,
cell
transplantation
secretome
therapy,
show
great
treatment
diseases,
challenges
tumorigenesis,
immune
rejection,
extraction
or
storage
need
be
addressed.
A
better
understanding
age-
disease-related
underlying
mechanism
driving
benefits
drawbacks
therapeutic
approaches
provide
insights
novel
disease-modifying
interventions
future
Язык: Английский
The Exciting Frontier of Neuroplasticity: Innovations in Brain Health and Recovery
Journal of Behavioral and Brain Science,
Год журнала:
2025,
Номер
15(03), С. 47 - 80
Опубликована: Янв. 1, 2025
Язык: Английский
Stem Cells in Cancer: From Mechanisms to Therapeutic Strategies
Cells,
Год журнала:
2025,
Номер
14(7), С. 538 - 538
Опубликована: Апрель 3, 2025
Stem
cells
have
emerged
as
a
pivotal
area
of
research
in
the
field
oncology,
offering
new
insights
into
mechanisms
cancer
initiation,
progression,
and
resistance
to
therapy.
This
review
provides
comprehensive
overview
role
stem
cancer,
focusing
on
(CSCs),
their
characteristics,
implications
for
We
discuss
origin
identification
CSCs,
tumorigenesis,
metastasis,
drug
resistance,
potential
therapeutic
strategies
targeting
CSCs.
Additionally,
we
explore
use
normal
therapy,
tissue
regeneration
delivery
vehicles
anticancer
agents.
Finally,
highlight
challenges
future
directions
cell
cancer.
Язык: Английский