DCLK1 in gastrointestinal cancer: A driver of tumor progression and a promising therapeutic target

International Journal of Cancer, Год журнала: 2025, Номер unknown

Опубликована: Март 8, 2025

Cancers of the gastrointestinal (GI) tract, including colorectal, pancreatic, and hepatocellular carcinomas, represent a significant global health burden due to their high incidence mortality rates. Doublecortin-like kinase 1 (DCLK1), initially identified for its role in neurogenesis, has emerged as crucial player GI cancer progression. This review comprehensively examines multifaceted roles DCLK1 cancers, focusing on structural isoforms, functions normal inflammatory states, contributions progression metastasis. is overexpressed various cancers associated with poor prognosis, enhanced tumorigenic potential, increased metastatic capacity. The discusses molecular mechanisms through which influences stem cell maintenance, epithelial-mesenchymal transition (EMT), survival pathways, well interactions key signaling pathways such Notch, WNT/β-catenin, NF-κB. potential therapeutic target also explored, highlighting preclinical early clinical efforts inhibit function using small molecule inhibitors or monoclonal antibodies. Despite advancements, further research needed fully elucidate DCLK1's develop effective strategies targeting this protein.

Язык: Английский

Breaking barriers: CAR-NK cell therapy breakthroughs in female-related cancers

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 187, С. 118071 - 118071

Опубликована: Апрель 19, 2025

Язык: Английский