Lipid-encapsulated gold nanoparticles: an advanced strategy for attenuating the inflammatory response in SARS-CoV-2 infection
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 15, 2025
Nanodrugs
play
a
crucial
role
in
biomedical
applications
by
enhancing
drug
delivery.
To
address
safety
and
toxicity
concerns
associated
with
nanoparticles,
lipid-nanocarrier-based
delivery
systems
have
emerged
as
promising
approach
for
developing
next-generation
smart
nanomedicines.
Ginseng
has
traditionally
been
used
various
therapeutic
purposes,
including
antiviral
activity.
This
study
aimed
to
prepare
biocompatible
therapeutically
potent
Korean
ginseng
nanoemulsion
(KGS-NE)
using
seed
oil
(GSO),
optimize
its
encapsulation
efficiency,
evaluate
Various
techniques
were
utilized
confirm
the
KGS-NE
formation.
Energy-dispersive
X-ray
spectroscopy
identified
gold
nanoparticles
highest
Au
peak
at
2.1
keV.
Selected
area
diffraction
patterns
revealed
crystallographic
structures.
FT-IR
spectrometry
detected
functional
groups,
peaks
2922.09
cm−1
(alkene
C–H
stretching),
1740.24
(aldehyde
C=O
1098.07
(C–O
stretching
secondary
alcohol).
Storage
stability
studies
showed
that
maintained
size
6
months
4
°C.
The
exhibited
dose-dependent
suppression
of
HCoV-OC43
viral
replication
Vero
E6
cells.
RNA
sequencing
analysis
unveiled
differentially
expressed
genes
(DEGs)
specifically
involved
ABC
transporters
signaling
pathway.
oral
administration
facilitated
recovery
mice
induced
receptor
binding
domain
(RBD)
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
spike
protein,
confirmed
inflammatory
markers
expression
lung
tissue.
In
Syrian
hamster
infected
SARS-CoV-2
model,
lungs
dissected
enlarged
morphology
cytokines.
effect
was
mitigated
administration,
observed
through
H&E
qRT-PCR
analysis.
Biochemical
concentrations
demonstrated
had
no
adverse
effects
on
kidney
liver.
Our
findings
strongly
suggest
administering
models
potential
effectively
mitigate
inflammation
against
coronavirus.
indicates
new
strategy
nano-agent
SARS-CoV-2.
Язык: Английский
‘I'm glad my baby has weaned so I don't need to make that decision.’ Understanding breastfeeding‐related COVID‐19 vaccine narratives on social media
Health Promotion Journal of Australia,
Год журнала:
2025,
Номер
36(2)
Опубликована: Март 11, 2025
Abstract
Issue
Addressed
During
the
coronavirus
disease
2019
(COVID‐19)
pandemic,
infodemic
has
been
highly
visible.
Vaccine‐related
advice
and
evidence‐based
guidelines
for
breastfeeding
women
have
lagged,
and,
at
times
contradictory
confusing.
Breastfeeding
is
an
important
public
health
issue
with
long‐lasting
benefits
infants
mothers.
This
online
social
listening
study
aimed
to
understand
breastfeeding‐related
narratives
on
media
during
early
stages
of
Australian
COVID‐19
vaccine
roll‐out.
Methods
Public
content
about
vaccines
from
Facebook
pages
Australian‐based
administrators
were
accessed
via
CrowdTangle
platform.
All
related
posted
between
1
December
2020–31
2021
was
included.
Content
(
n
=
29
567)
coded
adapted
narrative
typology,
emergent
themes
inductively
identified.
Results
Most
posts
promoting,
sharing
or
discussing
reliable
information.
However,
comments
responding
these
varied
more
widely.
Several
consistent
questions,
concerns,
information
voids
evident,
misinformation
conflicting
contributed
confusion
challenges
decision‐making.
Conclusions
These
findings
highlight
complexities
associated
Pregnant
continue
be
a
priority
group
vaccination,
yet
there
gaps
in
data,
evidence
Incorporating
management
into
work
important.
So
What?
Information
voids,
when
identified
early,
can
help
inform
messaging.
Increasing
training
skills
promotion
workforce
build
future
capacity
give
insight
optimising
communication
addressing
misinformation.
Язык: Английский
A Cross-sectional Study of Mental Health Effects of Excessive Screen Time and Social Media Use among Indian Adolescents and Young Adults
Journal of Nature and Science of Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 14, 2024
Abstract
Introduction:
The
impact
of
excessive
screen
time
and
social
media
use
on
mental
health,
particularly
among
adolescents
young
adults,
has
raised
concerns.
Objective:
objective
this
study
is
to
assess
the
health
effects
(13–19
years)
adults
(20–25
in
India.
Methods:
This
cross-sectional
online
survey
recruited
1392
participants
(672
720
adults)
from
Validated
scales
assessed
outcomes,
time,
use,
mediating
factors,
coping
strategies.
Descriptive
statistics,
correlation
analyses,
regression
models,
thematic
analysis
were
employed.
Results:
prevalence
depression
symptom
was
37.9%,
anxiety
33.3%,
high
stress
43.7%,
low
self-esteem
25.3%,
respectively.
Significant
positive
correlations
found
between
symptoms
(
r
=
0.32,
0.25),
0.28,
0.22),
0.36,
0.29),
while
negative
existed
with
−0.25,
−0.18).
Poor
sleep
quality
cyberbullying
exacerbated
issues,
physical
activity
support
had
protective
effects.
Common
strategies
included
activity,
hobbies,
support,
digital
detox,
mindfulness.
Conclusions:
provides
compelling
evidence
linking
adverse
outcomes
such
as
symptoms,
stress,
Indian
adults.
Key
factors
poor
exacerbating
reduced
protective.
While
recognizing
technology’s
benefits,
highlights
promoting
balanced
habits,
addressing
underlying
equipping
youth
skills
foster
a
healthier
relationship
technology
safeguard
well-being.
Язык: Английский
Social listening applied to tailor communication on immunization in the Republic of Moldova
European Journal of Public Health,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 28, 2024
Abstract
Although
the
Republic
of
Moldova
had
good
vaccination
rates,
anti-vax
messages
have
recently
begun
to
spread,
eroding
population’s
confidence.
Vaccination
coverage
against
measles,
mumps,
and
rubella
at
target
age
12
months
decreased
from
95%
in
2008
83%
2021.
The
recent
measles
outbreak
Romania
three
confirmed
cases
Moldova,
combined
with
refugee
crisis,
highlighted
importance
sparked
online
conversations
on
this
subject.
A
mixed-methods
study
was
conducted,
involving
social
listening
activities
immunization
using
Talkwalker
software
qualitative
analysis
identified
narratives.
Out
450
comments,
30
were
selected
for
further
analysis.
Over
5
months,
a
total
865
results
obtained,
an
engagement
rate
6300.
peak
occurred
between
11
18
December,
driven
by
Romania,
which
saw
several
one
death,
as
well
first
after
3
years.
However,
no
significant
increase
recorded.
Comments
tended
reflect
distrust
authorities
doctors,
political
ideological
views,
lack
knowledge
about
risks
vaccine-preventable
diseases.
analysed
are
assessed
having
low
risk
spreading,
though
some
employ
techniques
influence
or
manipulate
behaviours.
topic
is
used
promote
ideologies
through
issued
mass
media.
information
vacuum
must
be
filled
designed
produce
attitude
change
regarding
vaccination.
Язык: Английский