Honokiol relieves hippocampal neuronal damage in Alzheimer's disease by activating the SIRT3‐mediated mitochondrial autophagy

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(8)

Опубликована: Авг. 1, 2024

Abstract Background This work elucidated the effect of honokiol (HKL) on hippocampal neuronal mitochondrial function in Alzheimer's disease (AD). Methods APP/PS1 mice were used as AD models and exposed to HKL 3‐TYP. Morris water maze experiment was performed appraise cognitive performance mice. Hippocampal Aβ+ plaque deposition survival evaluated by immunohistochemistry Nissl staining. neurons dissociated from C57BL/6 mouse embryos. model constructed Aβ oligomers induction treated with HKL, CsA Neuronal viability apoptosis detected cell counting kit‐8 assay TUNEL mRFP–eGFP–LC3 assay, MitoSOX Red, dichlorodihydrofluorescein diacetate, JC‐1 staining monitor autophagosomes, reactive oxygen species (ROS), ROS, membrane potential. Autophagy‐related proteins Western blot. Results In mice, improved function, relieved 1–42 deposition, promoted neuron survival, activated SIRT3 expression autophagy. These effects abolished 3‐TYP treatment. model, increased activity, attenuated aggregation, autophagy, reduced elevated treatment abrogated protection model. The promotion autophagy counteracted Conclusions activates SIRT3‐mediated mitigate damage AD. may be effective treating

Язык: Английский

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The Crucial Role of the Blood–Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 386 - 386

Опубликована: Янв. 9, 2025

The blood-brain barrier (BBB) is a crucial structure that maintains brain homeostasis by regulating the entry of molecules and cells from bloodstream into central nervous system (CNS). Neurodegenerative diseases such as Alzheimer's Parkinson's disease, well ischemic stroke, compromise integrity BBB. This leads to increased permeability infiltration harmful substances, thereby accelerating neurodegeneration. In this review, we explore mechanisms underlying BBB disruption, including oxidative stress, neuroinflammation, vascular dysfunction, loss tight junction integrity, in patients with neurodegenerative diseases. We discuss how breakdown contributes neurotoxicity, abnormal accumulation pathological proteins, all which exacerbate neuronal damage facilitate disease progression. Furthermore, potential therapeutic strategies aimed at preserving or restoring function, anti-inflammatory treatments, antioxidant therapies, approaches enhance integrity. Given role neurodegeneration, maintaining its represents promising approach slow prevent progression

Язык: Английский

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Amyloid Β Fragments that Suppress Oligomers But Not Fibrils are Cytoprotective

Опубликована: Янв. 1, 2025

Язык: Английский

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Amyloid β fragments that suppress oligomers but not fibrils are cytoprotective

Archives of Biochemistry and Biophysics, Год журнала: 2025, Номер unknown, С. 110386 - 110386

Опубликована: Март 1, 2025

Язык: Английский

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Nanoparticles targeting the central circadian clock: Potential applications for neurological disorders

Advanced Drug Delivery Reviews, Год журнала: 2025, Номер unknown, С. 115561 - 115561

Опубликована: Март 1, 2025

Circadian rhythms and their involvement with various human diseases, including neurological disorders, have become an intense area of research for the development new pharmacological treatments. The location circadian clock machinery in central nervous system makes it challenging to reach molecular targets at therapeutic concentrations. In addition, a timely administration agents is necessary efficiently modulate clock. Thus, use nanoparticles dysfunctions may accelerate clinical translation by addressing these two key challenges: enhancing brain penetration and/or enabling formulation chronodelivery systems. This review describes implications pathologies, reviews potential modulators suggests how nanoparticle-based formulations could improve success. Finally, integration into chronopharmaceutical drug delivery systems will be described.

Язык: Английский

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Non-invasive neuromodulation assisted by exogenous stimuli-responsive nanoplatforms for Alzheimer’s disease and Parkinson's disease therapy

The Innovation Medicine, Год журнала: 2025, Номер unknown, С. 100121 - 100121

Опубликована: Янв. 1, 2025

<p>In recent decades, the incidence of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s (PD) has risen continuously, significantly impairing patients’ quality life while imposing growing economic social burdens. Traditional treatments exhibit limited effectiveness in halting progression. Non-invasive neuromodulation techniques, utilizing electromagnetic fields, light, or ultrasound, have emerged promising strategies to modulate neural activity alleviate symptoms. However, achieving spatially precise targeted remains challenging. The integration stimuli-responsive nanoplatforms addresses this limitation. These nanoplatforms, engineered respond specific stimuli, can deliver therapeutic agents desired brain regions. By enabling controlled localized drug release, they facilitate neuromodulation. Despite their potential, several hurdles must be overcome, including optimization nanoplatform design, elucidating complex nanoplatform-brain interactions, ensuring long-term safety efficacy. Nonetheless, combining non-invasive with holds revolutionary potential for therapy, offering targeted, personalized that may halt slow This comprehensive review explores applications assisted by exogenous AD PD therapy.</p>

Язык: Английский

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In vitro and In silico Anti-Alzheimer study of Rutin embedded with Zinc chloride loaded bovine serum albumin nanoparticles

Tissue and Cell, Год журнала: 2025, Номер 95, С. 102869 - 102869

Опубликована: Март 28, 2025

Язык: Английский

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Beneficial effects of mitophagy enhancers on amyloid beta-induced mitochondrial and synaptic toxicities in Alzheimer’s disease

Mitochondrion, Год журнала: 2025, Номер 83, С. 102038 - 102038

Опубликована: Март 29, 2025

Язык: Английский

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Engineered nanoparticles for the treatment of Alzheimer’s disease

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 3, 2025

Alzheimer’s disease (AD) is one of the most common diseases characterized by neurodegeneration and becoming a major public health problem worldwide. AD manifested mainly progressive impairments in cognition, emotion, language memory elderly population. Many treatment strategies have been explored for decades; however, there still no effective way to address root cause pathogenesis, only target symptoms improve patient cognitive outcomes. Intracerebral administration difficult because challenges posed blood‒brain barrier (BBB). NPs are materials with sizes between 1 100 nm that can biocompatibility, extend half-life, transport macromolecules, be delivered across BBB central nervous system, exhibit good targeting capabilities. provide new ideas terms their antiaging, antineuroinflammatory, antioxidative, nerve repair-promoting effects. In this manuscript, we first describe relationship BBB. Second, introduce application nanoparticles treatment. Finally, summarize faced AD.

Язык: Английский

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GCN-BBB: Deep Learning Blood-Brain Barrier (BBB) Permeability PharmacoAnalytics with Graph Convolutional Neural (GCN) Network

The AAPS Journal, Год журнала: 2025, Номер 27(3)

Опубликована: Апрель 3, 2025

Язык: Английский

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