Association of systemic inflammatory biomarkers with ocular disease: a large population-based cross-sectional study DOI Creative Commons
Xue Wang, Haitao Jiang, Can Zhang

и другие.

European journal of medical research, Год журнала: 2025, Номер 30(1)

Опубликована: Март 26, 2025

The aim of this study was to explore the association systemic inflammatory biomarkers (systemic immune-inflammation (SII) index and response (SIRI)) with prevalence ocular disease in general population United States (U.S.). We conducted a cross-sectional subjects National Health Nutrition Examination Survey 2005–2008 years. For analysis SII index, SIRI (glaucoma, cataract, age-related macular degeneration (ARMD), diabetic retinopathy), restricted cubic spline (RCS) plot, multivariable logistic regression models, subgroup were performed. There total 5377 individuals. As shown by RCS linked ARMD risk U-shaped pattern. Additionally, linearly positive glaucoma cataract. Finally, retinopathy associated L-shaped N-shaped curves SIRI, respectively. Two new biomarkers, are closely related eye disease. different associations between diseases. This should raise more concerns lead better prevention strategies for inflammation.

Язык: Английский

Enhancing Retinal Resilience: The Neuroprotective Promise of BDNF in Diabetic Retinopathy DOI Creative Commons
Daniela Maria Tănase, Emilia Valasciuc, Evelina Maria Gosav

и другие.

Life, Год журнала: 2025, Номер 15(2), С. 263 - 263

Опубликована: Фев. 9, 2025

Diabetic retinopathy (DR), a leading cause of vision impairment worldwide, is characterized by progressive damage to the retina due prolonged hyperglycemia. Despite advances in treatment, current interventions largely target late-stage vascular complications, leaving underlying neurodegenerative processes insufficiently addressed. This article explores crucial role neuronal survival, axonal growth, and synaptic plasticity neuroprotective potential Brain-Derived Neurotrophic Factor (BDNF) as therapeutic strategy for enhancing retinal resilience DR. Furthermore, it discusses innovative delivery methods BDNF, such gene therapy nanocarriers, which may overcome challenges achieving sustained targeted levels retina, focusing on early intervention preserve function prevent loss.

Язык: Английский

Процитировано

0
Association of systemic inflammatory biomarkers with ocular disease: a large population-based cross-sectional study DOI Creative Commons
Xue Wang, Haitao Jiang, Can Zhang

и другие.

European journal of medical research, Год журнала: 2025, Номер 30(1)

Опубликована: Март 26, 2025

The aim of this study was to explore the association systemic inflammatory biomarkers (systemic immune-inflammation (SII) index and response (SIRI)) with prevalence ocular disease in general population United States (U.S.). We conducted a cross-sectional subjects National Health Nutrition Examination Survey 2005–2008 years. For analysis SII index, SIRI (glaucoma, cataract, age-related macular degeneration (ARMD), diabetic retinopathy), restricted cubic spline (RCS) plot, multivariable logistic regression models, subgroup were performed. There total 5377 individuals. As shown by RCS linked ARMD risk U-shaped pattern. Additionally, linearly positive glaucoma cataract. Finally, retinopathy associated L-shaped N-shaped curves SIRI, respectively. Two new biomarkers, are closely related eye disease. different associations between diseases. This should raise more concerns lead better prevention strategies for inflammation.

Язык: Английский

Процитировано

0