Fasting for 20 h does not affect exercise‐induced increases in circulating BDNF in humans

The Journal of Physiology, Год журнала: 2023, Номер 601(11), С. 2121 - 2137

Опубликована: Янв. 11, 2023

Abstract Intermittent fasting and exercise provide neuroprotection from age‐related cognitive decline. A link between these two seemingly distinct stressors is their capability to steer the brain away exclusively glucose metabolism. This cerebral substrate switch has been implicated in upregulating brain‐derived neurotrophic factor (BDNF), a protein involved neuroplasticity, learning memory, may underlie some of neuroprotective effects. We examined isolated interactive effects (1) 20‐h fasting, (2) 90‐min light exercise, (3) high‐intensity on peripheral venous BDNF 12 human volunteers. follow‐up study influence cerebrovascular shear stress circulating BDNF. Fasting for 20 h decreased increased ketones ( P ≤ 0.0157) but had no effect ≥ 0.4637). Light cycling at 25% peak oxygen uptake () serum by 6 ± 8% (independent being fed or fasted) was mediated 7 6% increase platelets < 0.0001). Plasma 336 pg l −1 [46,626] 390 [127,653] = 0.0128). Six 40‐s intervals 100% plasma BDNF, as well BDNF‐per‐platelet ratio 4‐ 5‐fold more than did 0.0044). correlated with lactate during r 0.47, 0.0057), not 0.7407). Changes – whether occurring naturally induced experimentally inspired CO 2 correspond changes 0.2730). responses low‐intensity are platelets, increasing either duration particularly intensity required liberate free image Key points both have potent an acute upregulation (BDNF) appears be common mechanistic link. Switching brain's fuel source ketone bodies lactate, i.e. switch, shown promote production rodent brain. caused 9‐fold body delivery any metric circulation rest. Prolonged (90 min) plasma‐ serum‐derived irrespective fasted seemed independent stress. minutes every 4 5 times prolonged cycling; plasma‐derived 6‐fold feeding fasting. Compared 1 day without much efficient means circulation.

Язык: Английский

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Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice

Experimental & Molecular Medicine, Год журнала: 2023, Номер 55(9), С. 2067 - 2082

Опубликована: Сен. 13, 2023

Abstract Mounting evidence suggests that probiotics are beneficial for treating Alzheimer’s disease (AD). However, the mechanisms by which specific modify AD pathophysiology not clearly understood. In this study, we investigated whether Lactobacillus paracasei -derived extracellular vesicles ( Lpc -EV) can directly act on neuronal cells to amyloid-beta (Aβ)-induced transcriptional changes and Aβ pathology in brains of Tg-APP/PS1 mice. -EV treatment HT22 counteracts Aβ-induced downregulation Brain-derived neurotrophic factor (Bdnf) , Neurotrophin 3 (Nt3) Nt4/5 TrkB receptor, reverses altered expression diverse nuclear factors, including Methyl-CpG binding protein 2 (Mecp2) Sirtuin 1 (Sirt1) . Systematic siRNA-mediated knockdown experiments indicate upregulation Bdnf, Nt3, is mediated via multiple epigenetic factors whose activation converges Mecp2 Sirt1 addition, Aβ-degrading proteases Matrix metalloproteinase (Mmp-2) Mmp-9 Neprilysin (Nep) also controlled MeCP2 Sirt1. restores downregulated Nt4/5, Mmp-2, Nep ; induces hippocampus; alleviates accumulation neuroinflammatory responses brain; mitigates cognitive decline These results suggest cargo contains a neuroactive component upregulates ) through Sirt1, ameliorates deficits

Язык: Английский

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Esketamine Prevents Postoperative Emotional and Cognitive Dysfunction by Suppressing Microglial M1 Polarization and Regulating the BDNF-TrkB Pathway in Ageing Rats with Preoperative Sleep Disturbance

Molecular Neurobiology, Год журнала: 2024, Номер 61(8), С. 5680 - 5698

Опубликована: Янв. 15, 2024

Abstract Postoperative depression (POD) and postoperative cognitive dysfunction (POCD) have placed heavy burden on patients’ physical mental health in recent years. Sleep disturbance before surgery is a common phenomenon that has been increasingly believed to affect recovery, especially aged patients, while little attention paid sleep disruption the potential mechanism remains ambiguous. Ketamine reported attenuate POCD after cardiac elicit rapid-acting sustained antidepressant actions. The present study aimed clarify effect of esketamine’s (the S-enantiomer ketamine) protective effects possible mechanisms action POD. Our results showed exacerbated microglial M1 polarization BDNF-TrkB signalling induced by surgery, resulting emotional changes impairments. Notably, treatment with esketamine reversed behavioural abnormalities through inhibiting microglia inflammatory response thus improving vivo vitro. In addition, administration also impaired hippocampal synaptic plasticity which perturbed surgery. These findings warrant further investigations into interplay may provide novel ideas for implication preoperative preparations prevention brain-related complications.

Язык: Английский

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Exploring Advancements in Early Detection of Alzheimer's Disease with Molecular Assays and Animal Models

Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102411 - 102411

Опубликована: Июль 9, 2024

Язык: Английский

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Presenilin: A Multi-Functional Molecule in the Pathogenesis of Alzheimer’s Disease and Other Neurodegenerative Diseases

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1757 - 1757

Опубликована: Фев. 1, 2024

Presenilin, a transmembrane protein primarily known for its role in Alzheimer’s disease (AD) as part of the γ-secretase complex, has garnered increased attention due to multifaceted functions various cellular processes. Recent investigations have unveiled plethora beyond amyloidogenic role. This review aims provide comprehensive overview presenilin’s diverse roles AD and other neurodegenerative disorders. It includes summary well-known substrates presenilin, such involvement amyloid precursor (APP) processing Notch signaling, along with functions. Additionally, it highlights newly discovered functions, trafficking function, regulation ferritin expression, apolipoprotein E (ApoE) secretion, interaction ApoE Aβ42-to-Aβ40-converting activity ACE. updated perspective underscores evolving landscape presenilin research, emphasizing broader impact established pathways. The incorporation these novel findings accentuates dynamic nature processes, further advancing our comprehension By synthesizing evidence from range studies, this sheds light on intricate web their implications health disease.

Язык: Английский

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