Attenuating Effect of a Polyphenol Ellagic Acid on Ovarian Aging by Inhibiting the Ferroptosis Pathway in Low-Yield Laying Chickens DOI Creative Commons

Qiongyu Yuan,

Xinyu Wang,

Yingyu Xiao

и другие.

Antioxidants, Год журнала: 2025, Номер 14(5), С. 614 - 614

Опубликована: Май 21, 2025

Aging leads to ovarian degeneration in poultry, reducing egg production and quality. Ellagic acid (EA), a natural plant-derived compound, may help delay aging, though its precise mechanisms remain unclear. This study investigated the effects of EA on aging low-yield laying chickens explored underlying mechanism. supplementation (100 500 mg/kg) significantly increased weight as well number proportion small yellow follicles chickens. administration elevated serum antioxidant levels upregulated expression glutathione peroxidase 4 (GPX4) reduce oxidative stress. Importantly, treatment suppressed mRNA protein ferroptosis markers transferrin receptor 1 (TFRC) solute carrier family 7 member 11 (SLC7A11), Proliferating Cell Nuclear Antigen (PCNA) expression, alleviated G1 phase arrest granulosa cells (GCs), promoting cell proliferation, which improves quality production. Furthermore, vitro experiments demonstrated that decreased reactive oxygen species production, improved mitochondrial function, inhibited ferroptosis, attenuated GCs aging. In conclusion, this reveals critical role chicken suggests provide promising approach for delaying enhancing productivity poultry.

Язык: Английский

Research progress on quercetin in improving the survival rate of random skin flap DOI

Siping Xu,

Wenhua Zhang, Xuanfen Zhang

и другие.

Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)

Опубликована: Янв. 16, 2025

Язык: Английский

Процитировано

0
Attenuating Effect of a Polyphenol Ellagic Acid on Ovarian Aging by Inhibiting the Ferroptosis Pathway in Low-Yield Laying Chickens DOI Creative Commons

Qiongyu Yuan,

Xinyu Wang,

Yingyu Xiao

и другие.

Antioxidants, Год журнала: 2025, Номер 14(5), С. 614 - 614

Опубликована: Май 21, 2025

Aging leads to ovarian degeneration in poultry, reducing egg production and quality. Ellagic acid (EA), a natural plant-derived compound, may help delay aging, though its precise mechanisms remain unclear. This study investigated the effects of EA on aging low-yield laying chickens explored underlying mechanism. supplementation (100 500 mg/kg) significantly increased weight as well number proportion small yellow follicles chickens. administration elevated serum antioxidant levels upregulated expression glutathione peroxidase 4 (GPX4) reduce oxidative stress. Importantly, treatment suppressed mRNA protein ferroptosis markers transferrin receptor 1 (TFRC) solute carrier family 7 member 11 (SLC7A11), Proliferating Cell Nuclear Antigen (PCNA) expression, alleviated G1 phase arrest granulosa cells (GCs), promoting cell proliferation, which improves quality production. Furthermore, vitro experiments demonstrated that decreased reactive oxygen species production, improved mitochondrial function, inhibited ferroptosis, attenuated GCs aging. In conclusion, this reveals critical role chicken suggests provide promising approach for delaying enhancing productivity poultry.

Язык: Английский

Процитировано

0