Frontiers in Bioscience-Landmark,
Год журнала:
2024,
Номер
29(4), С. 149 - 149
Опубликована: Апрель 11, 2024
Background:
The
diagnostic
potential
of
circular
RNAs
(circRNAs)
in
circulating
exosomes
for
acute
myocardial
infarction
(AMI)
is
not
well
understood,
despite
existing
research
indicating
their
role
cardiovascular
diseases.
This
study
aimed
to
clarify
the
significance
exosomal
as
indicators
AMI.
Methods:
We
examined
120
individuals
diagnosed
with
AMI
and
83
non-cardiogenic
chest
pain
(NCCP),
all
previously
enrolled
a
conducted
study.
High-throughput
sequencing
identify
differentially
expressed
circRNAs
patients.
To
validate,
we
employed
Real-Time
polymerase
chain
reaction
(RT-PCR)
targeting
five
that
exhibited
notable
increase.
Results:
identified
893
altered
expression
patients,
including
118
up-regulated
775
down-regulated
circRNAs.
Genes
linked
these
were
enriched
crucial
Kyoto
Encyclopedia
Genomes
(KEGG)
pathways,
highlighting
direct
relevance
pathophysiology.
Three
(hsa_circ_0001558,
hsa_circ_0001535,
hsa_circ_0000972)
showed
significant
up-regulation
patients
during
initial
validation
cohort.
corresponding
area
under
curve
(AUC)
values
0.79,
0.685,
0.683,
respectively.
Further
hsa_circ_0001558
second
cohort
4.45-fold
increase
AUC
=
0.793.
rise
was
particularly
noticeable
non-ST-elevation
(NSTEMI)
(2.80
times,
0.72)
ST-elevation
(STEMI)
(5.27
0.831)
compared
NCCP.
Conclusions:
Our
findings
demonstrate
differences
patterns
plasma
between
NCCP
Specifically,
appears
promising
indicator
diagnosis.
necessary
fully
evaluate
context
AMI,
emphasizing
importance
findings.
Non-Coding RNA,
Год журнала:
2024,
Номер
10(1), С. 13 - 13
Опубликована: Фев. 7, 2024
Plant
species
utilize
a
variety
of
regulatory
mechanisms
to
ensure
sustainable
productivity.
Within
this
intricate
framework,
numerous
non-coding
RNAs
(ncRNAs)
play
crucial
role
in
plant
biology,
surpassing
the
essential
functions
RNA
molecules
as
messengers,
ribosomal,
and
transfer
RNAs.
ncRNAs
represent
an
emerging
class
regulators,
operating
directly
form
small
interfering
(siRNAs),
microRNAs
(miRNAs),
long
noncoding
(lncRNAs),
circular
(circRNAs).
These
exert
control
at
various
levels,
including
transcription,
post-transcription,
translation,
epigenetic.
Furthermore,
they
interact
with
each
other,
contributing
biological
processes
associated
stress
resilience.
This
review
primarily
concentrates
on
recent
advancements
ncRNAs,
delineating
their
growth
development
across
organs
such
root,
leaf,
seed/endosperm,
seed
nutrient
development.
Additionally,
broadens
its
scope
by
examining
response
environmental
stresses
drought,
salt,
flood,
heat,
cold
plants.
compilation
offers
updated
information
insights
guide
characterization
potential
growth,
development,
resilience
future
research.
Cell Research,
Год журнала:
2024,
Номер
34(9), С. 609 - 629
Опубликована: Июль 25, 2024
The
advent
of
high-throughput
sequencing
uncovered
that
our
genome
is
pervasively
transcribed
into
RNAs
are
seemingly
not
translated
proteins.
It
was
also
found
non-coding
RNA
transcripts
outnumber
canonical
protein-coding
genes.
This
mindboggling
discovery
prompted
a
surge
in
research
started
unraveling
the
functional
relevance
these
new
genetic
units,
shaking
classic
definition
"gene".
While
revolution
still
taking
place,
polysome/ribosome
profiling
and
mass
spectrometry
analyses
revealed
peptides
can
be
from
non-canonical
open
reading
frames.
Therefore,
it
becoming
evident
coding
vs
dichotomy
way
blurrier
than
anticipated.
In
this
review,
we
focus
on
several
examples
which
binary
classification
genes
outdated,
since
same
bifunctional
gene
expresses
both
products.
We
discuss
implications
intricate
usage
terms
molecular
mechanisms
expression
biological
outputs,
often
concordant,
but
surprisingly
discordant.
Finally,
methodological
caveats
associated
with
study
genes,
highlight
opportunities
challenges
therapeutic
exploitation
intricacy
towards
development
anticancer
therapies.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 10, 2024
Abstract
Cervical
cancer
(CC)
is
a
common
gynecologic
malignancy,
accounting
for
significant
proportion
of
women
death
worldwide.
Human
papillomavirus
(HPV)
infection
one
the
major
etiological
causes
leading
to
CC
onset;
however,
genetic,
and
epigenetic
factors
are
also
responsible
disease
expansion.
Circular
RNAs
(circRNAs),
which
known
as
particular
subset
non-coding
RNA
(ncRNA)
superfamily,
with
covalently
closed
loop
structures,
have
been
reported
be
involved
in
progression
diverse
diseases,
especially
neoplasms.
In
this
framework,
abnormally
expressed
circRNAs
strong
correlation
pathogenesis
through
regulating
substantial
signaling
pathways.
Also,
these
molecules
can
considered
promising
biomarkers
therapeutic
targets
diagnosis/prognosis
treatment,
respectively.
Herein,
we
first
review
key
molecular
mechanisms,
including
Wnt/β-catenin,
MAPK,
PI3K/Akt/mTOR
pathways,
well
angiogenesis
metastasis,
by
interfere
development.
Then,
diagnostic,
prognostic,
potentials
ncRNA
will
highlighted
depth.
Circular
RNAs
(circRNAs)
are
unique
noncoding
that
have
a
closed
and
stable
loop
structure
generated
through
backsplicing.
Due
to
their
conservation,
stability
tissue
specificity,
circRNAs
can
potentially
be
used
as
diagnostic
indicators
therapeutic
targets
for
certain
tumors.
Many
studies
shown
act
microRNA
(miRNA)
sponges,
engage
in
interactions
with
proteins
translation
templates
regulate
gene
expression
signal
transduction,
thereby
participating
the
occurrence
development
of
variety
malignant
Immunotherapy
has
revolutionized
treatment
cancer.
Early
researches
indicated
involved
regulating
tumor
immune
microenvironment
antitumor
immunity.
CircRNAs
may
potential
important
increasing
sensitivity
immunotherapy
expanding
population
patients
who
benefit
from
cancer
immunotherapy.
However,
few
investigated
correlation
between
In
this
review,
we
summarize
current
on
regulation
different
mechanisms
value
efficacy
goal
providing
new
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Авг. 26, 2024
Abstract
The
global
incidence
of
thyroid
cancer
has
increased
over
recent
decades.
Papillary
(PTC)
is
the
most
common
type
and
accounts
for
nearly
90%
all
cases.
Typically,
PTC
a
good
prognosis.
However,
some
variants
exhibit
more
aggressive
behaviour,
which
significantly
increases
risk
postoperative
recurrence.
Over
past
decade,
high
metastatic
potential
drawn
attention
many
researchers
these
studies
have
provided
useful
molecular
markers
improved
diagnosis,
stratification
clinical
approaches.
aim
this
review
to
discuss
progress
in
epidemiology,
features,
factors
mechanisms
associated
with
aggressiveness.
We
present
detailed
picture
showing
that
epithelial-to-mesenchymal
transition,
metabolic
reprogramming,
alterations
important
signalling
pathways,
epigenetic
aberrations
tumour
microenvironment
are
crucial
drivers
metastasis.
Further
research
needed
fully
elucidate
pathogenesis
biological
behaviour
underlying
aggressiveness
PTC.
International Journal of Surgery,
Год журнала:
2024,
Номер
110(4), С. 2323 - 2337
Опубликована: Янв. 18, 2024
Spindle
and
kinetochore-associated
complex
subunit
3
(SKA3)
is
a
microtubule-binding
subcomplex
of
the
outer
kinetochore,
which
plays
vital
role
in
proper
chromosomal
segregation
cell
division.
Recently,
SKA3
have
been
demonstrated
its
oncogenic
tumorigenesis
development
cancers.
In
this
review,
authors
comprehensively
deciphered
human
cancer
from
various
aspects,
including
bibliometrics,
pan-cancer
analysis,
narrative
summary.
The
also
provided
top
10
predicted
drugs
targeting
SKA3.
proposed
that
was
potential
target
brought
new
therapeutic
opportunities
for
patients.
