The Microbiota of the Human Mammary Ecosystem

Frontiers in Cellular and Infection Microbiology, Год журнала: 2020, Номер 10

Опубликована: Ноя. 20, 2020

Human milk contains a dynamic and complex site-specific microbiome, which is not assembled in an aleatory way, formed by organized microbial consortia networks. Presence of some genera, such as Staphylococcus, Streptococcus, Corynebacterium, Cutibacterium (formerly known Propionibacterium ), Lactobacillus , Lactococcus Bifidobacterium has been detected both culture-dependent culture-independent approaches. DNA from gut-associated strict anaerobes also repeatedly found studies have revealed the presence cells and/or nucleic acids viruses, archaea, fungi protozoa human milk. Colostrum microbes are transmitted to infant and, therefore, they among first colonizers gut. Still, significance gut colonization remains open question. Clinical trying elucidate question confounded profound impact non-microbial components intestinal microecology. Modifications microbiota may biological consequences for colonization, metabolism, immune neuroendocrine development, mammary health. However, factors driving differences composition microbiome remain poorly known. In addition colostrum milk, breast tissue lactating non-lactating women contain microbiota, with implications pathogenesis cancer adverse outcomes associated implants. This other issues, origin current limitations future prospects addressed this review.

Язык: Английский

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Nutrient Level Determines Biofilm Characteristics and Subsequent Impact on Microbial Corrosion and Biocide Effectiveness

Applied and Environmental Microbiology, Год журнала: 2020, Номер 86(7)

Опубликована: Янв. 24, 2020

Microbiologically influenced corrosion (MIC) is a complex process that generates economic losses to the industry every year. Corrosion must be managed prevent loss of containment produced fluids external environment. MIC management includes identification assets with higher risk, which could by nutrient levels in system. Assessing biofilms under different conditions essential for understanding impact flow regime on microbial communities and subsequent effectiveness biocide treatment. This investigation simulates closely oil production systems, contain piping sections exposed continuous remain stagnant long periods. Therefore, results reported here are useful prevention. Moreover, complementary methodological approach applied this highlighted importance implementing RNA-based methods better active microorganisms survive stress systems.

Язык: Английский

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Global airborne microbial communities controlled by surrounding landscapes and wind conditions

Scientific Reports, Год журнала: 2019, Номер 9(1)

Опубликована: Окт. 8, 2019

Abstract The atmosphere is an important route for transporting and disseminating microorganisms over short long distances. Understanding how are distributed in the critical due to their role public health, meteorology atmospheric chemistry. In order determine dominant processes that structure airborne microbial communities, we investigated diversity abundance of both bacteria fungi from PM10 particle size (particulate matter 10 micrometers or less diameter) as well particulate chemistry local meteorological characteristics time at nine different stations around world. bacterial genera Bacillus Sphingomonas fungal species Pseudotaeniolina globaosa Cladophialophora proteae were most abundant taxa dataset, although relative abundances varied greatly based on sampling site. Bacterial concentration was highest high-altitude semi-arid plateau Namco (China; 3.56 × 6 ± 3.01 cells/m 3 ) vegetated mountain peak Storm-Peak (Colorado, USA; 8.78 4 6.49 ), respectively. Surrounding ecosystems, especially within a 50 km perimeter our stations, main contributors composition communities. Temporal stability communities mainly explained by evenness surrounding landscapes wind direction variability time. Airborne appear be result large inputs nearby sources with possible low diluted distant sources.

Язык: Английский

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Genotypic and Phenotypic Diversity among Human Isolates of Akkermansia muciniphila

mBio, Год журнала: 2021, Номер 12(3)

Опубликована: Май 17, 2021

The mucophilic anaerobic bacterium Akkermansia muciniphila is a prominent member of the gastrointestinal (GI) microbiota and only known species Verrucomicrobia phylum in mammalian gut. A high prevalence A. adult humans associated with leanness lower risk for development obesity diabetes. Four distinct phylogenetic groups have been described, but little about their relative abundance or how they impact human metabolic health. In this study, we isolated characterized 71 new strains from cohort children adolescents undergoing treatment obesity. Based on genomic phenotypic analysis these strains, found several phylogroup-specific phenotypes that may colonization GI tract modulate host functions, such as oxygen tolerance, adherence to epithelial cells, iron sulfur metabolism, bacterial aggregation. antibiotic-treated mice, phylogroups AmIV AmII outcompeted AmI strains. adolescents, were most prominent, observed variance single phylogroup dominance, switching occurring small subset patients. Overall, results highlight ecological principles determining which predominates are complex strain genetic diversity represent an important variable should be taken into account when making inferences microbe's its host's health.IMPORTANCE linked multiple positive health outcomes. There four phylogroups, yet vary ability influence largely unknown. performed identified traits adherence, acquisition likely differentially immunological humans, predominate at given time phylotype can switch individual. This collection provides foundation functional characterization effects multitude outcomes colonization, including protection obesity, diabetes, colitis, neurological diseases, well enhanced responses cancer immunotherapies.

Язык: Английский

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Predictive genomic traits for bacterial growth in culture versus actual growth in soil

The ISME Journal, Год журнала: 2019, Номер 13(9), С. 2162 - 2172

Опубликована: Май 3, 2019

Язык: Английский

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