The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly

The Lancet Microbe, Год журнала: 2022, Номер 3(12), С. e969 - e983

Опубликована: Сен. 29, 2022

Язык: Английский

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Gut microbiome lipid metabolism and its impact on host physiology

Cell Host & Microbe, Год журнала: 2023, Номер 31(2), С. 173 - 186

Опубликована: Фев. 1, 2023

Язык: Английский

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Drug-microbiota interactions: an emerging priority for precision medicine

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Окт. 9, 2023

Abstract Individual variability in drug response (IVDR) can be a major cause of adverse reactions (ADRs) and prolonged therapy, resulting substantial health economic burden. Despite extensive research pharmacogenomics regarding the impact individual genetic background on pharmacokinetics (PK) pharmacodynamics (PD), diversity explains only limited proportion IVDR. The role gut microbiota, also known as second genome, its metabolites modulating therapeutic outcomes human diseases have been highlighted by recent studies. Consequently, burgeoning field pharmacomicrobiomics aims to explore correlation between microbiota variation IVDR or ADRs. This review presents an up-to-date overview intricate interactions classical agents for systemic diseases, including cancer, cardiovascular (CVDs), endocrine others. We summarise how directly indirectly, modify absorption, distribution, metabolism, excretion (ADME) drugs. Conversely, drugs modulate composition function leading changes microbial metabolism immune response. discuss practical challenges, strategies, opportunities this field, emphasizing critical need develop innovative approach multi-omics, integrate various data types, genomic data, well translate lab into clinical practice. To sum up, represents promising avenue address improve patient outcomes, further is imperative unlock full potential precision medicine.

Язык: Английский

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A genomic compendium of cultivated human gut fungi characterizes the gut mycobiome and its relevance to common diseases

Cell, Год журнала: 2024, Номер 187(12), С. 2969 - 2989.e24

Опубликована: Май 21, 2024

Язык: Английский

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Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3

Microbiome, Год журнала: 2024, Номер 12(1)

Опубликована: Фев. 20, 2024

Abstract Background Remodeling eubiosis of the gut microenvironment may contribute to preventing occurrence and development depression. Mounting experimental evidence has shown that complement C3 signaling is associated with pathogenesis depression, disruption microbiota be an underlying cause system activation. However, mechanism by which participates in gut-brain crosstalk depression remains unknown. Results In present study, we found chronic unpredictable mild stress (CUMS)-induced mice exhibited obvious depression-like behavior as well cognitive impairment, was significant dysbiosis, especially enrichment Proteobacteria elevation microbiota-derived lipopolysaccharides (LPS). addition, peripheral central activation C3/CR3-mediated aberrant synaptic pruning microglia have also been observed. Transplantation from CUMS-induced model into specific pathogen-free germ-free induced concomitant impairment recipient mice, accompanied increased C3/CR3 pathway prefrontal cortex abnormalities microglia-mediated pruning. Conversely, antidepressants fecal transplantation antidepressant-treated donors improved behaviors restored microbiome disturbances depressed mice. Concurrently, inhibition pathway, amelioration abnormal pruning, expression synapsin postsynaptic density protein 95 were Collectively, our results revealed dysbiosis induces through synapse C3, key targeting microbes treat Conclusions Our findings provide novel insights involvement chemotactic

Язык: Английский

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The mycobiome in human cancer: analytical challenges, molecular mechanisms, and therapeutic implications

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 15, 2025

The polymorphic microbiome is considered a new hallmark of cancer. Advances in High-Throughput Sequencing have fostered rapid developments research. interaction between cancer cells, immune and microbiota defined as the immuno-oncology (IOM) axis. Fungal microbes (the mycobiome), although representing only ∼ 0.1-1% microbiome, are critical immunologically active component tumor microbiome. Accumulating evidence suggests possible involvement commensal pathogenic fungi initiation, progression, treatment responsiveness. tumor-associated mycobiome mainly consists gut mycobiome, oral intratumoral mycobiome. However, role remains poorly understood, diversity complexity analytical methods make it challenging to access this field. This review aims elucidate causal complicit roles development progression while highlighting issues that need be addressed executing such We systematically summarize advantages limitations current fungal detection analysis methods. enumerate integrate these recent findings into our understanding accompanied by prospect novel exhilarating clinical implications.

Язык: Английский

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Microbiota and COVID-19: Long-term and complex influencing factors

Frontiers in Microbiology, Год журнала: 2022, Номер 13

Опубликована: Авг. 12, 2022

The coronavirus disease 2019 (COVID-19) is an infectious caused by severe acute respiratory syndrome 2 (SARS-CoV-2). According to the World Health Organization statistics, more than 500 million individuals have been infected and 6 deaths resulted worldwide. Although COVID-19 mainly affects system, considerable evidence shows that digestive, cardiovascular, nervous, reproductive systems can all be involved. Angiotensin-converting enzyme (AEC2), target of SARS-CoV-2 invasion host distributed in gastrointestinal tract. Studies found microbiota contributes onset progression many diseases, including COVID-19. Here, we firstly conclude characterization respiratory, gut, oral microbial dysbiosis, bacteria, fungi, viruses. Then explore potential mechanisms involvement Microbial dysbiosis could influence complex interactions with immunity. Moreover, may impact on through their metabolites or modulation ACE2 expression. Subsequently, generalize as diagnostic markers for patients its possible association post-acute (PACS) relapse after recovery. Finally, proposed directed microbiota-targeted treatments from perspective gut microecology such probiotics prebiotics, fecal transplantation antibiotics, other interventions traditional Chinese medicine, vaccines, ACE2-based treatments.

Язык: Английский

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Fungi and cancer

Gut, Год журнала: 2023, Номер 72(7), С. 1410 - 1425

Опубликована: Май 5, 2023

The microbiome may impact cancer development, progression and treatment responsiveness, but its fungal components remain insufficiently studied in this context. In review, we highlight accumulating evidence suggesting a possible involvement of commensal pathogenic fungi modulation cancer-related processes. We discuss the mechanisms by which can influence tumour biology, locally activity exerted within microenvironment, or remotely through secretion bioactive metabolites, host immunity communications with neighbouring bacterial commensals. examine prospects utilising fungi-related molecular signatures diagnosis, patient stratification assessment while highlighting challenges limitations faced performing such research. all, demonstrate that likely constitute important members mucosal tumour-residing microbiomes. Exploration inter-kingdom interactions decoding their causal impacts on biology enable harnessing into diagnosis treatment.

Язык: Английский

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Host Factors Associated with Gut Mycobiome Structure

mSystems, Год журнала: 2023, Номер 8(2)

Опубликована: Фев. 14, 2023

Recent studies revealed a significant role of the gut fungal community in human health. Here, we investigated content and variation mycobiota among subjects from European population. We explored interplay between fungi various host-related sociodemographic, lifestyle, health, dietary factors. The study included 923 participants. Fecal DNA samples were analyzed by whole-metagenome high-throughput sequencing. Subsequently, taxonomic profiles determined accompanied computational statistical analyses association with 53 Fungal communities characterized high prevalence Saccharomyces, Candida, Sporisorium. Ten factors found to correlate significantly overall variation. Most diet related, including consumption chips, meat, sodas, sweetening, processed food, alcohol, followed age marital status. Differences α- and/or β-diversity also reported for other such as body mass index (BMI), job type, autoimmunological diseases, probiotics. Differential abundance analysis species that exhibited different patterns changes under specific conditions. is dominated yeast, Malassezia, Candida. Although intervolunteer variability was high, several persisted across most samples, which may be evidence core exists. Moreover, showed diet, age, status influence mycobiota. To our knowledge, this first large comprehensive cohort terms associations an extensive differentiated set IMPORTANCE inhabited many organisms, bacteria fungi, affect However, research on mycobiome still rare. European-based missing. Our results beer, alcohol consumption, associated abundances at level can suggest potentially valuable paths further, narrowly focused its impact In coming era microbiome-based precision medicine, further into relationship mycobial structures result new preventive approaches or therapeutic procedures.

Язык: Английский

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Neglected gut microbiome: interactions of the non-bacterial gut microbiota with enteric pathogens

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Июнь 26, 2023

A diverse array of commensal microorganisms inhabits the human intestinal tract. The most abundant and studied members this microbial community are undoubtedly bacteria. Their important role in gut physiology, defense against pathogens, immune system education has been well documented over last decades. However, microbiome is not restricted to It encompasses entire breadth life: viruses, archaea, fungi, protists, parasitic worms can also be found gut. While less than bacteria, their divergent but roles during health disease have become increasingly more appreciated. This review focuses on these understudied microbiome. We will detail composition development communities specifically highlight functional interactions with enteric such as species family

Язык: Английский

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