Fucoidan Ameliorated Dextran Sulfate Sodium-Induced Ulcerative Colitis by Modulating Gut Microbiota and Bile Acid Metabolism

Journal of Agricultural and Food Chemistry, Год журнала: 2022, Номер 70(47), С. 14864 - 14876

Опубликована: Ноя. 15, 2022

Gut dysbiosis and bile acid (BA) metabolism disturbance are involved in the pathogenesis of ulcerative colitis. This study aimed to investigate effect fucoidan on BA gut microbiota dextran sulfate sodium-induced colitis mice. Our results showed that effectively suppressed colonic inflammation repaired barrier. In addition, increased relative abundance Lachnospiraceae family, such as Turicibacter, Muribaculum, Parasutterella, Colidextribacter, followed by an increase short-chain fatty acids, especially butyrate. Moreover, modulated elevating cholic acid, ursodeoxycholic deoxycholic lithocholic decreasing β-muricholic which led activation FXR TGR5 further enhanced barrier inflammation. revealed alleviating was largely mediated microbiota, confirmed fecal transplantation experiment. Collectively, these findings provided basis for a potential functional food

Язык: Английский

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Drug-microbiota interactions: an emerging priority for precision medicine

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Окт. 9, 2023

Abstract Individual variability in drug response (IVDR) can be a major cause of adverse reactions (ADRs) and prolonged therapy, resulting substantial health economic burden. Despite extensive research pharmacogenomics regarding the impact individual genetic background on pharmacokinetics (PK) pharmacodynamics (PD), diversity explains only limited proportion IVDR. The role gut microbiota, also known as second genome, its metabolites modulating therapeutic outcomes human diseases have been highlighted by recent studies. Consequently, burgeoning field pharmacomicrobiomics aims to explore correlation between microbiota variation IVDR or ADRs. This review presents an up-to-date overview intricate interactions classical agents for systemic diseases, including cancer, cardiovascular (CVDs), endocrine others. We summarise how directly indirectly, modify absorption, distribution, metabolism, excretion (ADME) drugs. Conversely, drugs modulate composition function leading changes microbial metabolism immune response. discuss practical challenges, strategies, opportunities this field, emphasizing critical need develop innovative approach multi-omics, integrate various data types, genomic data, well translate lab into clinical practice. To sum up, represents promising avenue address improve patient outcomes, further is imperative unlock full potential precision medicine.

Язык: Английский

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Gut microbiota-derived ursodeoxycholic acid alleviates low birth weight-induced colonic inflammation by enhancing M2 macrophage polarization

Microbiome, Год журнала: 2023, Номер 11(1)

Опубликована: Янв. 31, 2023

Low birth weight (LBW) is associated with intestinal inflammation and dysbiosis after birth. However, the underlying mechanism remains largely unknown.In present study, we aimed to investigate metabolism, therapeutic potential, mechanisms of action bile acids (BAs) in LBW-induced a piglet model.The fecal microbiome BA profile between LBW normal (NBW) neonatal piglets were compared. Fecal microbiota transplantation (FMT) was employed further confirm linkage microbial metabolism inflammation. The potential ursodeoxycholic acid (UDCA), highly differentially abundant NBW piglets, alleviating colonic evaluated both an LBW-FMT mice model, DSS-induced colitis mouse model. cellular molecular by which UDCA suppresses also investigated DSS-treated macrophage cell line. Microbiomes analyzed using 16S ribosomal RNA sequencing. profiles measured targeted metabolomics. Levels farnesoid X receptor (FXR) knocked down J774A.1 cells small interfering RNAs.We show significant difference animals Transplantation antibiotic-treated leads Importantly, oral administration UDCA, major diminished tract markedly alleviates model inducing M2 polarization. Mechanistically, reduces inflammatory cytokine production engaging FXR while suppressing NF-κB activation macrophages.These findings establish causal relationship LBW-associated abnormalities dysbiosis, suggesting that restoring health postnatal maldevelopment infants may be achieved targeting metabolism. Video Abstract.

Язык: Английский

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Colonization and development of the gut microbiome in calves

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Год журнала: 2023, Номер 14(1)

Опубликована: Апрель 9, 2023

Abstract Colonization and development of the gut microbiome are crucial for growth health calves. In this review, we summarized colonization, beneficial nutrition, immune function microbiota, barrier, evolution core microbiota in calves different ages. Homeostasis is nutritional system Disruption leads to digestive diseases calves, such as diarrhea intestinal inflammation. Microbiota already exists calf fetuses, colonization continues change dynamically under influence various factors, which include probiotics, diet, age, genotype. depends on interaction between The abundance diversity these commensal stabilize play a critical role

Язык: Английский

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Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases

Cells, Год журнала: 2023, Номер 12(14), С. 1888 - 1888

Опубликована: Июль 19, 2023

The intestinal barrier is a precisely regulated semi-permeable physiological structure that absorbs nutrients and protects the internal environment from infiltration of pathological molecules microorganisms. Bile acids are small synthesized cholesterol in liver, secreted into duodenum, transformed to secondary or tertiary bile by gut microbiota. interact with acid receptors (BARs) microbiota, which plays key role maintaining homeostasis barrier. In this review, we summarize discuss recent studies on disorder associated dysfunction related diseases. We focus roles acids, BARs, microbiota triggering dysfunction. Insights for future prevention treatment diseases provided.

Язык: Английский

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Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner

Cell Metabolism, Год журнала: 2024, Номер 36(2), С. 408 - 421.e5

Опубликована: Фев. 1, 2024

Язык: Английский

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Extracellular vesicles derived from Lactobacillus johnsonii promote gut barrier homeostasis by enhancing M2 macrophage polarization

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Март 1, 2024

Diarrheic disease is a common intestinal health problem worldwide, causing great suffering to humans and animals. Precise manipulation strategies based on probiotics combat diarrheic diseases have not been fully developed.

Язык: Английский

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The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Янв. 22, 2025

The gut microbiome has emerged as a pivotal area of research due to its significant influence on the immune system and cognitive functions. Cognitive disorders, including dementia Parkinson’s disease, represent substantial global health challenges. This review explores relationship between microbiota, modulation, decline, with particular focus gut-brain axis. Research indicates that bacteria produce metabolites, short-chain fatty acids (SCFAs), which affect mucosal immunity, antigen presentation, responses, thereby influencing A noteworthy correlation been identified imbalances in impairments, suggesting novel pathways for treatment disorders. Additionally, factors such diet, environment, pharmaceuticals play role shaping composition microbiome, subsequently impacting both health. article aims clarify complex interactions among regulation, evaluating their potential therapeutic targets. goal is promote microbiome-based treatments lay groundwork future this field.

Язык: Английский

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Versatile Triad Alliance: Bile Acid, Taurine and Microbiota

Cells, Год журнала: 2022, Номер 11(15), С. 2337 - 2337

Опубликована: Июль 29, 2022

Taurine is the most abundant free amino acid in body, and mainly derived from diet, but can also be produced endogenously cysteine. It plays multiple essential roles including development, energy production, osmoregulation, prevention of oxidative stress, inflammation. crucial as a molecule used to conjugate bile acids (BAs). In gastrointestinal tract, BAs deconjugation by enteric bacteria results high levels unconjugated taurine. Depending on conjugation status other bacterial modifications, constitute pool related highly diverse molecules, each with different properties concerning solubility toxicity, capacity activate or inhibit receptors BAs, direct indirect impact microbiota host, whereas taurine has largely protective serves source for microbiota, regulates colonization defends pathogens. Several remarkable examples interaction between gut have recently been described. This review will introduce necessary background information lay out latest discoveries co-reliant triad taurine, microbiota.

Язык: Английский

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Human umbilical cord mesenchymal stem cells ameliorate colon inflammation via modulation of gut microbiota-SCFAs-immune axis

Stem Cell Research & Therapy, Год журнала: 2023, Номер 14(1)

Опубликована: Сен. 25, 2023

Abstract Background Inflammatory bowel disease (IBD) is a global health problem in which gut microbiota dysbiosis plays pivotal pathogenic role. Mesenchymal stem cells (MSCs) therapy has emerged as prospective novel tool for managing IBD, and can also regulate the composition of microbiota. However, functional significance MSCs-induced changes microbiome poorly understood. Methods Here, we investigated first time role mediating protective effect human umbilical cord MSCs (HUMSCs) on DSS-induced colitis. Gut alteration short-chain fatty acids (SCFAs) production were analyzed through 16S rRNA sequencing targeted metabolomics. Spectrum antibiotic cocktail (ABX), fecal transplantation (FMT) sterile filtrate (SFF) employed to evaluate intestinal flora its metabolites. Cytokine microarray, Enzyme-linked immunosorbent assay (ELISA), flow cytometry conducted assess CD4 + T homeostasis. Results By performing depletion experiments, revealed that derived from ameliorated colon inflammation reshaped T-cells immune homeostasis via remodeling diversity flora, especially up-regulated SCFAs-producing bacterial abundance, such Akkermansia , Faecalibaculum Clostridia_UCG_014 . Consistently, metabolomics manifested increased SCFAs with administration, there was significant positive correlation between differential bacteria SCFAs. Meanwhile, combined gavage underlying mechanism further associated improved Treg/Th2/Th17 balance mucosa mediated microbiota-derived production. Conclusion The present study advances understanding effects colitis, providing evidence new microbiome-metabolite-immune axis recovery colitis by MSCs.

Язык: Английский

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