Frontiers in Endocrinology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 23, 2023
Objective
Chronic
hypercortisolism
leads
to
a
phenotype
resembling
metabolic
syndrome.
We
aimed
investigate
the
association
between
gut
microbiota
and
abnormalities
in
endogenous
(Cushing’s
syndrome).
Methods
A
total
of
23
patients
with
Cushing’s
syndrome
(18
female
5
men,
aged
47.24
±
12.99
years)
30
age-,
sex-and
BMI-matched
healthy
controls
12
45.03
6.69
were
consecutively
recruited.
Differences
plasma
short-chain
fatty
acid
(SCFAs)
concentrations
analyzed
by
16S
rRNA
sequencing
gas
chromatography-mass
spectrometry
(GC-MS).
Results
Compared
controls,
Simpson
Pielou
indices
α
diversity
dramatically
decreased
(
P
<
0.05).
The
community
structure
differed
significantly
controls.
bacterial
communities
enriched
Proteobacteria
Escherichia-Shigella
,
depleted
Firmicutes
including
Agathobacter
Blautia
Anaerostipes
Eubacterium_eligens_group
Lachnospira
.
Spearman
analysis
demonstrated
that
HbA1c,
SBP,
DBP,
cortisol
levels
positively
correlated
whereas
negatively
Agathobacter,
Blautia,
Anaerostipes,
Eubacterium_hallii_group,
etc.
also
had
lower
propionic
concentration
(0.151±0.054
vs.
0.205±0.032
µg/mL,
=0.039)
than
Furthermore,
level
was
systolic
pressure
<0.05).
Conclusion
Gut
dysbiosis
observed
Cushing’s,
suggesting
may
be
potential
therapeutic
intervention
target
improve
hypercortisolism-related
abnormalities.
Abstract
Background
Gut
microbiome
is
a
community
of
microorganisms
that
lives
in
the
human
intestine
and
exerts
various
functions
on
host,
including
metabolic,
immunoregulatory,
control
over
cell
proliferation.
alterations
have
been
associated
with
pathological
conditions,
such
as
diabetes
mellitus,
obesity,
cardiovascular
diseases.
Gut‐prostate
axis
explained
by
association
between
gut
quantitative
functional
along
increased
intestinal
epithelial
permeability
prostatediseases.
However,
pathophysiological
mechanisms
clinical
importance
this
are
not
completely
clarified
yet.
Methods
We
conducted
narrative
review
most
relevant
articles
Medline
(US
National
Library
Medicine,
Bethesda,
MD,
USA),
Scopus
(Elsevier,
Amsterdam,
The
Netherlands)
Web
Science
Core
Collection
(Thomson
Reuters,
Toronto,
ON,
Canada)
databases.
No
chronological
restrictions
were
applied,
related
papers
published
until
December
2023
included.
Results
microbiota
(GM)
its
metabolites
capable
modifying
host
androgen
level,
well
prostate
cancer
(PCa)
therapy
response.
Moreover,
patients
inflammatory
bowel
disease
higher
rates
prostatitis‐like
symptoms
potential
risk
developing
PCa.
Conclusions
There
evidence
interventions
GM
high
to
serve
diagnostic
therapeutic
tools
for
diseases,
Microbiology Spectrum,
Год журнала:
2024,
Номер
12(5)
Опубликована: Апрель 11, 2024
ABSTRACT
Microorganisms
are
a
crucial
component
of
lake
ecosystems
and
significant
contributors
to
biogeochemical
cycles.
However,
the
understanding
how
primary
microorganism
groups
(e.g.,
bacteria
fungi)
distributed
constructed
within
different
habitats
is
lacking.
We
investigated
bacterial
fungal
communities
Hulun
Lake
using
high-throughput
sequencing
techniques
targeting
16S
rRNA
Internal
Transcribed
Spacer
2
genes,
including
range
ecological
statistical
methodologies.
Our
findings
reveal
that
environmental
factors
have
high
spatial
temporal
variability.
The
composition
community
structures
vary
significantly
depending
on
differences
in
habitats.
Variance
partitioning
analysis
showed
geographical
accounted
for
<20%
variation.
Canonical
correlation
among
factors,
temperature,
pH,
dissolved
oxygen
had
strong
control
over
microbial
communities.
(bacterial
fungal)
were
primarily
controlled
by
dispersal
limitations
stochastic
processes.
This
study
offers
fresh
perspectives
regarding
maintenance
mechanism
biodiversity
ecosystems,
especially
responses
under
identical
stress.
IMPORTANCE
an
important
part
freshwater
ecosystem.
microorganisms
play
role
material
circulation
energy
flow
owing
their
unique
enzymatic
metabolic
capacity.
In
this
study,
we
observed
varied
widely
water
sediments
Lake.
factor
affecting
formation
was
identified
as
limitation
during
Environmental
variation
communities,
with
being
factors.
provide
new
insights
into
fungi
environment,
shed
light
processes
building,
deepen
our
ecosystems.
results
reference
management
conservation,
particularly
respect
monitoring
response
changes.
International Journal of Oncology,
Год журнала:
2024,
Номер
65(1)
Опубликована: Июнь 6, 2024
Several
studies
have
indicated
that
the
gut
microbiome
and
tumor
microbiota
may
affect
tumors.
Emerging
metabolomics
research
illustrates
need
to
examine
variations
in
microbial
metabolite
composition
between
patients
with
cancer
healthy
individuals.
Microbial
metabolites
can
impact
progression
of
tumors
immune
response
by
influencing
a
number
mechanisms,
including
modulation
system,
or
immune‑related
signaling
pathways,
epigenetic
modification
proteins
DNA
damage.
also
alleviate
side
effects
drug
resistance
during
chemotherapy
immunotherapy,
while
effectively
activating
system
exert
immunotherapy.
Nevertheless,
on
immunity
be
both
beneficial
harmful,
potentially
influenced
concentration
specific
type.
The
present
review
summarizes
roles
various
different
solid
tumors,
alongside
their
influence
treatment.
Additionally,
clinical
trials
evaluating
therapeutic
related
microbes
been
listed.
In
summary,
studying
metabolites,
which
play
crucial
role
interaction
could
lead
identification
new
supplementary
treatments
for
cancer.
This
has
potential
improve
effectiveness
treatment
enhance
patient
prognosis.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 5, 2024
Cancer
remains
a
leading
cause
of
global
mortality.
The
tumor
microbiota
has
increasingly
been
recognized
as
key
regulator
cancer
onset
and
progression,
in
addition
to
shaping
responses
immunotherapy.
Microbes,
including
viruses,
bacteria,
fungi,
other
eukaryotic
species
can
impact
the
internal
homeostasis
health
humans.
Research
focused
on
gut
microflora
intratumoral
microbiome
revolutionized
current
understanding
how
tumors
grow,
progress,
resist
therapeutic
interventions.
Even
with
this
research,
however,
there
relatively
little
that
is
known
respect
abundance
microbes
their
effects
microenvironment.
Engineered
exosomes
are
class
artificial
extracellular
nanovesicles
actively
transport
small
molecule
drugs
nucleic
acids,
which
have
broad
prospects
cell
therapy.
present
review
offers
an
overview
recent
progress
challenges
associated
engineered
context
research.
These
discussions
used
inform
construction
novel
framework
for
exosome-mediated
targeted
drug
delivery,
taking
advantage
diversity
strategic
asset
thereby
providing
new
opportunities
more
effectively
treat
manage
clinic.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 23, 2023
Objective
Chronic
hypercortisolism
leads
to
a
phenotype
resembling
metabolic
syndrome.
We
aimed
investigate
the
association
between
gut
microbiota
and
abnormalities
in
endogenous
(Cushing’s
syndrome).
Methods
A
total
of
23
patients
with
Cushing’s
syndrome
(18
female
5
men,
aged
47.24
±
12.99
years)
30
age-,
sex-and
BMI-matched
healthy
controls
12
45.03
6.69
were
consecutively
recruited.
Differences
plasma
short-chain
fatty
acid
(SCFAs)
concentrations
analyzed
by
16S
rRNA
sequencing
gas
chromatography-mass
spectrometry
(GC-MS).
Results
Compared
controls,
Simpson
Pielou
indices
α
diversity
dramatically
decreased
(
P
<
0.05).
The
community
structure
differed
significantly
controls.
bacterial
communities
enriched
Proteobacteria
Escherichia-Shigella
,
depleted
Firmicutes
including
Agathobacter
Blautia
Anaerostipes
Eubacterium_eligens_group
Lachnospira
.
Spearman
analysis
demonstrated
that
HbA1c,
SBP,
DBP,
cortisol
levels
positively
correlated
whereas
negatively
Agathobacter,
Blautia,
Anaerostipes,
Eubacterium_hallii_group,
etc.
also
had
lower
propionic
concentration
(0.151±0.054
vs.
0.205±0.032
µg/mL,
=0.039)
than
Furthermore,
level
was
systolic
pressure
<0.05).
Conclusion
Gut
dysbiosis
observed
Cushing’s,
suggesting
may
be
potential
therapeutic
intervention
target
improve
hypercortisolism-related
abnormalities.
