A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite–CerS6–ceramide axis

Science, Год журнала: 2025, Номер 388(6746)

Опубликована: Май 1, 2025

The gut microbiota is known to be associated with a variety of human metabolic diseases, including dysfunction–associated steatohepatitis (MASH). Fungi are increasingly recognized as important members this community; however, the role fungal symbionts in diseases unknown. We have systematically isolated and characterized fungi, identifying Fusarium foetens an intestinal symbiotic filamentous fungus mice. F. reverses MASH progression mouse models through ceramide synthetase 6 (CerS6)–ceramide axis. Moreover, we identified FF-C1, secondary metabolite from , CerS6 inhibitor that has endogenous protective effect on progression.

Язык: Английский

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Extremozymes: Challenges and opportunities on the road to novel enzymes production

Process Biochemistry, Год журнала: 2024, Номер 143, С. 323 - 336

Опубликована: Май 3, 2024

Язык: Английский

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Culturing the uncultured marine fungi in the omics age: Opportunities and challenges

Fungal Biology Reviews, Год журнала: 2024, Номер 48, С. 100353 - 100353

Опубликована: Янв. 4, 2024

Язык: Английский

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Mangrove sediments are environmental hotspots for pathogenic protists

Journal of Hazardous Materials, Год журнала: 2024, Номер 467, С. 133643 - 133643

Опубликована: Фев. 2, 2024

Язык: Английский

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The right tool for the job: Chemical biology and microbiome science

Cell chemical biology, Год журнала: 2025, Номер 32(1), С. 83 - 97

Опубликована: Янв. 1, 2025

Язык: Английский

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Three novel species and a new record of Pleosporales (Didymellaceae, Roussoellaceae) from China

MycoKeys, Год журнала: 2025, Номер 113, С. 295 - 320

Опубликована: Фев. 12, 2025

We are investigating saprobic Ascomycota in Guizhou Province, China. Fungal specimens collected from dead wood were identified based on morphological characteristics and multi-gene phylogenetic analyses of ITS, SSU, LSU, β-tubulin, ef1-α, rpb2 sequence data. Three novel species, Neoroussoellaguizhouensis, Roussoellaguizhouensis, Xenodidymellaguizhouensis, introduced, along with one new geographical record, Xenoroussoellatriseptata. This study contributes to our understanding the diversity Province classification Roussoellaceae.

Язык: Английский

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Fungi promote cross-domain interactions even in deep anoxic mangrove sediments

Environmental Microbiome, Год журнала: 2025, Номер 20(1)

Опубликована: Март 25, 2025

Abstract Background Microbial communities in mangrove sediments play vital ecological roles that underpin the functioning of overall ecosystem. Fungal communities, particular, are known to crucial across sediment systems, yet their sediments, especially deeper layers, remain poorly understood without a comprehensive inter-domain characterization. To better understand fungal horizons, 10 cores extending down depth 1 m were taken three sites characterise archaeal, bacterial, and at cm intervals. Results We demonstrate has distinct effects on microbial communities. While community compositions similar depths, bacterial archaeal stratified into surface (10–30 cm), subsurface (40–60 deep (70–100 cm). Co-occurrence networks then constructed investigate fungi these where consistently identified as keystone taxa maintaining network topology, with co-domain interactions constituting more than half all interactions. Even deepest layer, nodes still retained high betweenness centralities, acting hubs potentially augment for Conclusions Overall, our results emphasise important role mediating depths even deep, anoxic highlight importance cross-domain integral holistic understanding microbiome.

Язык: Английский

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Monitoring of potential microbial sources of taste and odor in drinking water systems: A novel actinobacterial medium development and application

Water Research, Год журнала: 2025, Номер unknown, С. 123573 - 123573

Опубликована: Март 1, 2025

Язык: Английский

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Bionectriaceae: a poorly known family of hypocrealean fungi with major commercial potential

Studies in Mycology, Год журнала: 2025, Номер 111(1), С. 115 - 392

Опубликована: Апрель 18, 2025

Язык: Английский

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Two new species of Penicillium (Eurotiales, Aspergillaceae) from China based on morphological and molecular analyses

MycoKeys, Год журнала: 2025, Номер 116, С. 255 - 274

Опубликована: Апрель 25, 2025

Penicillium is a large and significant genus of fungi, exhibiting widespread distribution across diverse substrates. Ongoing taxonomic nomenclatural revisions have led to an annual increase in the number newly described species. This study two new species, i.e., P.lentum P.tibetense, discovered China. They been identified characterized through morphological examination both single gene multigene phylogenetic analyses. Based on these analyses, was classified within section Brevicompacta, while P.tibetense placed Lanata-Divaricata. Both species exhibited features typical their respective sections. Penicilliumlentum by restricted growth with dense colonies agar media predominantly generates terverticillate conidiophores. Penicilliumtibetense demonstrates rapid has vigorous CYA at 30 °C, producing biverticillate Comprehensive descriptions detailed illustrations were presented. A comparison between closely related taxa provided.

Язык: Английский

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