Revista de Gestão Social e Ambiental,
Год журнала:
2025,
Номер
19(3), С. e011670 - e011670
Опубликована: Март 20, 2025
Objective:
The
study
aimed
to
conduct
a
review
of
new
azoles
derivatives
tackle
the
critical
priority
pathogens
World
Health
Organization
(WHO).
Theoretical
background:
Azoles
are
main
class
antifungal
drugs,
and
creation
drugs
based
on
their
fundamental
structure
could
be
viable
alternative
for
combating
listed
by
WHO
as
due
high
mortality
resistance.
Method:
used
databases
such
PubMed,
Scopus
Science
Direct,
with
articles
published
between
2019
2024.
Papers
addressing
infections
caused
these
fungi
azole
an
against
were
included,
20
selected.
Results
discussion:
list
highlights
Candida
albicans,
Cryptococcus
neoformans,
Aspergillus
fumigatus
auris,
which
in
urgent
need
therapeutic
alternatives.
Experimental
studies
have
revealed
significant
advances
structural
modification
azoles,
especially
relation
hybrid
compounds
combining
triazole
oxadiazole
nuclei
containing
hydrophobic
substituents,
broad
spectrum
mechanisms
action.
Research
implications:
Resistance
has
increased
globally
threatens
effectiveness
available
treatments.
synthesis
can
help
fill
gaps,
modifications
serve
basis
development
improved
Originality
value:
Novel
molecules,
combination
cores,
introduction
groups,
not
only
increase
efficacy,
but
also
improve
penetration
into
biofilms
thermal
stability.
These
innovations
represent
advance
treatment
fungal
therapies.
Molecules,
Год журнала:
2025,
Номер
30(5), С. 1165 - 1165
Опубликована: Март 5, 2025
This
study
reports
the
synthesis,
characterization,
and
antifungal
evaluation
of
a
series
pyridoxal
salicylaldehyde
derivatives,
using
synthetic
methodologies
such
as
radical
cyclizations
click
chemistry.
Compounds
6a
6b,
featuring
fused
dihydrobenzoxepine-pyridine
scaffold,
demonstrated
effective
fungicidal
activity
with
MIC
values
19
µg/mL
against
Cryptococcus
neoformans
2807.
Similarly,
compound
6b
exhibited
notable
75
Candida
auris
PUJ-HUSI
537.
Both
compounds
outperformed
fluconazole
(FLC)
in
these
strains.
In
silico
ADMET
profiling
revealed
favorable
pharmacokinetic
properties,
including
blood-brain
barrier
penetration
drug-likeness
parameters
consistent
Lipinski's
rule
five.
Cytotoxicity
assays
on
human
fibroblasts
confirmed
low
toxicity
at
tested
concentrations.
These
results
highlight
potential
scaffold
promising
candidate
for
further
investigations.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2494 - 2494
Опубликована: Март 11, 2025
Various
species
of
fungi
can
be
detected
in
the
environment
and
within
human
body,
many
which
may
become
pathogenic
under
specific
conditions,
leading
to
various
forms
fungal
infections.
Antimicrobial
peptides
(AMPs)
are
evolutionarily
ancient
components
immune
response
that
quickly
induced
infections
with
pathogens
almost
all
tissues.
There
is
a
wide
range
AMP
classes
humans,
exhibit
broad-spectrum
antimicrobial
function.
This
review
provides
comprehensive
overview
mechanisms
action
AMPs,
their
distribution
antifungal
activity
against
both
common
rare
clinical
pathogens.
It
also
discusses
current
research
status
promising
novel
strategies,
highlighting
challenges
must
overcome
development
these
therapies.
The
hope
peptides,
as
class
agents,
will
soon
progress
through
large-scale
trials
implemented
practice,
offering
new
treatment
options
for
patients
suffering
from
Expert Review of Anti-infective Therapy,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Introduction
Despite
the
crucial
importance
of
effective
AFS
in
resource-limited
settings,
such
settings
remain
comparatively
underserved
and
underrepresented
terms
resource-setting-specific
guidance
research.
Further
practical
contextualization
application
current
best
practices
is
thus
necessary.
Revista de Gestão Social e Ambiental,
Год журнала:
2025,
Номер
19(3), С. e011670 - e011670
Опубликована: Март 20, 2025
Objective:
The
study
aimed
to
conduct
a
review
of
new
azoles
derivatives
tackle
the
critical
priority
pathogens
World
Health
Organization
(WHO).
Theoretical
background:
Azoles
are
main
class
antifungal
drugs,
and
creation
drugs
based
on
their
fundamental
structure
could
be
viable
alternative
for
combating
listed
by
WHO
as
due
high
mortality
resistance.
Method:
used
databases
such
PubMed,
Scopus
Science
Direct,
with
articles
published
between
2019
2024.
Papers
addressing
infections
caused
these
fungi
azole
an
against
were
included,
20
selected.
Results
discussion:
list
highlights
Candida
albicans,
Cryptococcus
neoformans,
Aspergillus
fumigatus
auris,
which
in
urgent
need
therapeutic
alternatives.
Experimental
studies
have
revealed
significant
advances
structural
modification
azoles,
especially
relation
hybrid
compounds
combining
triazole
oxadiazole
nuclei
containing
hydrophobic
substituents,
broad
spectrum
mechanisms
action.
Research
implications:
Resistance
has
increased
globally
threatens
effectiveness
available
treatments.
synthesis
can
help
fill
gaps,
modifications
serve
basis
development
improved
Originality
value:
Novel
molecules,
combination
cores,
introduction
groups,
not
only
increase
efficacy,
but
also
improve
penetration
into
biofilms
thermal
stability.
These
innovations
represent
advance
treatment
fungal
therapies.
