A Novel Approach to Explore Metabolic Diseases: Neddylation DOI Creative Commons
Huiwen Ren, Zhilin Luan, Ruijing Zhang

и другие.

Pharmacological Research, Год журнала: 2024, Номер 210, С. 107532 - 107532

Опубликована: Дек. 1, 2024

Protein post translational modification (PTM) is the main regulatory mechanism for eukaryotic cell function, among which ubiquitination based on reversible degradation of proteins by ubiquitin proteasome system to regulate homeostasis. The neural precursor expressed developmental downregulated gene 8 (NEDD8) a kind like protein that shares 80 % homology and 60 identity with ubiquitin. PTM process covalently binding NEDD8 lysine residues in called neddylation. neddylation reaction could be regulated NEDD8, its precursors, substrates, E1 activating enzymes, E2 E3 ligases, de-neddylases, inhibitors, such as MLN4924. widely whole structure multiple tissues species, related factors are highly metabolism adrenal glands, thyroid parathyroid skeletal muscles, myocardium, adipose tissues, metabolic cardiovascular, cerebrovascular liver diseases, adipogenic osteogenic differentiation, well tumor glycolysis glucose resulting from angiogenesis endothelial disfunction, hepatotoxicity, adipogenesis, osteogenesis, Warburg effect, insulin function. This review provides researchers new approach explore diseases via searching analyzing histological, cytological, subcellular localization specific molecules databases, exploring mediating terms development pre-clinical pharmacological inhibitors.

Язык: Английский

A Novel Approach to Explore Metabolic Diseases: Neddylation DOI Creative Commons
Huiwen Ren, Zhilin Luan, Ruijing Zhang

и другие.

Pharmacological Research, Год журнала: 2024, Номер 210, С. 107532 - 107532

Опубликована: Дек. 1, 2024

Protein post translational modification (PTM) is the main regulatory mechanism for eukaryotic cell function, among which ubiquitination based on reversible degradation of proteins by ubiquitin proteasome system to regulate homeostasis. The neural precursor expressed developmental downregulated gene 8 (NEDD8) a kind like protein that shares 80 % homology and 60 identity with ubiquitin. PTM process covalently binding NEDD8 lysine residues in called neddylation. neddylation reaction could be regulated NEDD8, its precursors, substrates, E1 activating enzymes, E2 E3 ligases, de-neddylases, inhibitors, such as MLN4924. widely whole structure multiple tissues species, related factors are highly metabolism adrenal glands, thyroid parathyroid skeletal muscles, myocardium, adipose tissues, metabolic cardiovascular, cerebrovascular liver diseases, adipogenic osteogenic differentiation, well tumor glycolysis glucose resulting from angiogenesis endothelial disfunction, hepatotoxicity, adipogenesis, osteogenesis, Warburg effect, insulin function. This review provides researchers new approach explore diseases via searching analyzing histological, cytological, subcellular localization specific molecules databases, exploring mediating terms development pre-clinical pharmacological inhibitors.

Язык: Английский

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