Gene Signature-Based Prognostic Model for Acute Myeloid Leukemia: The Role of BATF, EGR1, PD-1, PD-L1, and TIM-3 DOI Creative Commons
Yupei Zhang, Zhixi Chen,

Jiamian Zheng

и другие.

International Journal of Medical Sciences, Год журнала: 2025, Номер 22(8), С. 1875 - 1884

Опубликована: Март 19, 2025

Background: Acute myeloid leukemia (AML) is a malignancy of hematopoietic stem and progenitor cells, with T cell exhaustion linked to poor outcomes. Our previous research has shown that basic leucine zipper ATF-like transcription factor (BATF) early growth response 1 (EGR1) play role in chimeric antigen receptor (CAR-T) during AML tumor elimination. However, the roles BATF EGR1 their association immune checkpoint genes prognosis remain underexplored. Methods: Bone marrow (BM) samples from 92 newly diagnosed patients at our clinical center (JUN-dataset) were analyzed detect expression levels BATF, EGR1, programmed death (PD-1), death-ligand (PD-L1), immunoglobulin mucin domain-containing protein 3 (TIM3) together conducting prognostic assessment. findings validated using RNA sequencing data 155 TCGA database 199 Beat-AML database. Results: High correlated overall survival (OS) (P = 0.030), whereas high indicated favorable 0.040). Patients low had worst outcomes < 0.001). Among those receiving allogenic transplantation (allo-HSCT), was shorter OS 0.004). Moreover, model incorporating PD-1, PD-L1, TIM-3 calculated risk score, high-risk demonstrating significantly than low-risk both total allo-HSCT recipients Similar results found datasets. Conclusions: We establish based on effectively predicts for recipients. This may provide valuable insights assessment treatment strategies.

Язык: Английский

Gene Signature-Based Prognostic Model for Acute Myeloid Leukemia: The Role of BATF, EGR1, PD-1, PD-L1, and TIM-3 DOI Creative Commons
Yupei Zhang, Zhixi Chen,

Jiamian Zheng

и другие.

International Journal of Medical Sciences, Год журнала: 2025, Номер 22(8), С. 1875 - 1884

Опубликована: Март 19, 2025

Background: Acute myeloid leukemia (AML) is a malignancy of hematopoietic stem and progenitor cells, with T cell exhaustion linked to poor outcomes. Our previous research has shown that basic leucine zipper ATF-like transcription factor (BATF) early growth response 1 (EGR1) play role in chimeric antigen receptor (CAR-T) during AML tumor elimination. However, the roles BATF EGR1 their association immune checkpoint genes prognosis remain underexplored. Methods: Bone marrow (BM) samples from 92 newly diagnosed patients at our clinical center (JUN-dataset) were analyzed detect expression levels BATF, EGR1, programmed death (PD-1), death-ligand (PD-L1), immunoglobulin mucin domain-containing protein 3 (TIM3) together conducting prognostic assessment. findings validated using RNA sequencing data 155 TCGA database 199 Beat-AML database. Results: High correlated overall survival (OS) (P = 0.030), whereas high indicated favorable 0.040). Patients low had worst outcomes < 0.001). Among those receiving allogenic transplantation (allo-HSCT), was shorter OS 0.004). Moreover, model incorporating PD-1, PD-L1, TIM-3 calculated risk score, high-risk demonstrating significantly than low-risk both total allo-HSCT recipients Similar results found datasets. Conclusions: We establish based on effectively predicts for recipients. This may provide valuable insights assessment treatment strategies.

Язык: Английский

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