Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

Cancer Communications, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Abstract Copper, one of the essential nutrients for human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses copper lead cellular fragility. Therefore, it can manifest pro‐ anti‐cancer properties tumors. is crucial clarify activity within cell. We have thoughtfully summarized metabolic activities from a macro micro perspective. Cuproptosis, well other forms cell death, directly or indirectly interfered with by Cu 2+ , causing cancer death. Meanwhile, we did pan‐cancer analysis cuproptosis‐related genes further roles these genes. In addition, has been found be involved metastasis cells. Given complexity copper's role, are compelled ask: friend foe? Up now, used various clinical applications, including protocols measurement concentration bioimaging radioactive 64 Cu. But therapeutically still continuation old medicine, new possibilities need explored, such use nanomaterials. Some studies also shown that considerable interventional power cancers, which provides great applications potential therapy specific types. This paper reviews dual played cuproptosis perspectives oxidative stress, tumor metastasis, points out value application types, summarizes testing imaging perspective current feasible options drugs, emphasizes prospects nano‐copper.

Язык: Английский

Integrating cuproptosis and immunosenescence: A novel therapeutic strategy in cancer treatment

Biochemistry and Biophysics Reports, Год журнала: 2025, Номер 42, С. 101983 - 101983

Опубликована: Март 29, 2025

Язык: Английский