Nanoscale, Год журнала: 2024, Номер unknown
Опубликована: Дек. 23, 2024
The differentiation of human induced pluripotent stem cells (hiPSCs) into neural progenitor (NPCs) is a promising approach for the treatment neurodegenerative diseases and regenerative medicine.
Язык: Английский
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 25, 2025
Central nervous system (CNS) disorders confront significant challenges in drug delivery due to the blood-brain barrier (BBB). Inspired by rapid and precise binding of odor molecules olfactory receptors (ORs), this research uses thiolated HPMA construct nanoparticles (nanoodors) capable delivering drugs CNS via olfacto-cerebral pathway overcome obstruction. The nanoodor core is used encapsulate agomelatine (AGO), a CNS-targeting antidepressant, encapsulation efficiency exceeded 80%. A series thiol-presenting nanoscale structures with different surface densities thiol groups are constructed, effectiveness positively correlated density on their surface. Notably, nanoodors enable brain-targeted delivery, outperforming commercially available oral formulations terms accumulation brain antidepressant effects. study transport action mechanisms revealed that after ORs, rapidly delivered pathway. Nanoodors, first design deliver mimicking natural smells for treatment disorders, expected achieve clinical transformation, benefiting human health.
Язык: Английский
Процитировано
1
Nanotechnology in the life sciences, Год журнала: 2025, Номер unknown, С. 183 - 202
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
EBioMedicine, Год журнала: 2025, Номер 113, С. 105605 - 105605
Опубликована: Март 1, 2025
Extracellular vesicles (EVs) are lipid-enclosed nanovesicles secreted by diverse cell types that orchestrate intercellular communication through cargo delivery. Their pivotal roles span from supporting the development of normal central nervous system (CNS) to contributing pathogenesis neurological diseases. Particularly noteworthy is their involvement in propagation pathogenic proteins, such as those involved neurodegenerative disorders, and nucleic acids, closely linking them disease onset progression. Moreover, EVs have emerged promising diagnostic biomarkers for disorders tools staging, owing ability traverse blood-brain barrier specific, stable, accessible properties. This review comprehensively explores realm CNS-derived found peripheral blood, encompassing detection methods, transport mechanisms, various Furthermore, we evaluate potentials limitations clinical applications highlight prospective research directions this rapidly evolving field.
Язык: Английский
Процитировано
0
Journal of Biomedical Science, Год журнала: 2024, Номер 31(1)
Опубликована: Авг. 25, 2024
Abstract Extracellular vesicles (EVs) are vital for cell-to-cell communication, transferring proteins, lipids, and nucleic acids in various physiological pathological processes. They play crucial roles immune modulation tissue regeneration but also involved pathogenic conditions like inflammation degenerative disorders. EVs have heterogeneous populations cargo, with numerous subpopulations currently under investigations. EV therapy shows promise stimulating repair serving as a drug delivery vehicle, offering advantages over cell therapy, such ease of engineering minimal risk tumorigenesis. However, challenges remain, including inconsistent nomenclature, complex characterization, underdeveloped large-scale production protocols. This review highlights the recent advances significance heterogeneity, emphasizing need better understanding their disease pathologies to develop tailored therapies clinical applications neurological Graphical abstract
Язык: Английский
Процитировано
2
Nanoscale, Год журнала: 2024, Номер unknown
Опубликована: Дек. 23, 2024
The differentiation of human induced pluripotent stem cells (hiPSCs) into neural progenitor (NPCs) is a promising approach for the treatment neurodegenerative diseases and regenerative medicine.
Язык: Английский
Процитировано
0