Varna Medical Forum,
Год журнала:
2023,
Номер
12(2), С. 126 - 126
Опубликована: Сен. 1, 2023
Caloric
restriction
is
a
reduction
in
caloric
intake
without
reaching
state
of
malnutrition,
and
it
affects
multiple
cellular
signaling
pathways.
Experimental
data
shows
that
this
leads
to
an
increase
longevity
or
maintaining
healthy
for
extended
period
both
invertebrates
vertebrates,
including
mammals.
Certain
food
compounds
drugs
possess
the
ability
replicate
these
effects
through
shared
mechanisms;
they
are
known
as
mimetics
(CRM).
What
have
common
induce
autophagy
by
stimulating
deacetylation
proteins.
In
addition,
modulate
energy
metabolism
reduce
oxidative
stress.
The
current
review
aims
explore
mechanisms
potential
outcomes
CRM
utilization
addressing
metabolic
syndrome,
with
emphasis
on
polyphenols
metformin.
Their
influence
carbohydrate
lipid
metabolism,
their
antioxidant
anti-inflammatory
actions,
well
modulation
gut
microbiota
emphasize
suitability
managing
syndrome.
These
at
least
partially
mediated
same
pathways
activated
restriction,
such
adenosine
monophosphate-activated
protein
kinase,
mammalian
target
rapamycin
(mTOR),
sirtuins,
peroxisome
proliferator-activated
receptor
gamma
coactivator
1-alpha
(PGC-1ɑ),
many
others,
participating
complex
interactions.
suggests
innovative
approach
prevention
therapy
age-related
non-communicable
diseases,
showcasing
significant
targeting
Biomolecules,
Год журнала:
2024,
Номер
14(3), С. 260 - 260
Опубликована: Фев. 22, 2024
Anti-ageing
biology
and
medicine
programmes
are
a
focus
of
genetics,
molecular
biology,
immunology,
endocrinology,
nutrition,
therapy.
This
paper
discusses
metabolic
therapies
aimed
at
prolonging
longevity
and/or
health.
Individual
components
these
effects
postulated
to
be
related
the
energy
supply
by
tricarboxylic
acid
(TCA)
cycle
intermediates
free
radical
production
processes.
article
presents
several
theories
ageing
clinical
descriptions
top
markers
ageing,
which
define
in
different
categories;
additionally,
their
interactions
with
age-related
changes
diseases
α-ketoglutarate
(AKG)
succinate
SC
formation
metabolism
pathological
states
explained.
review
describes
convincingly
differences
mitochondrial
characteristics
animals,
levels
(high
low)
physiological
reactivity
functional
systems
state
regulatory
providing
oxygen-dependent
Much
attention
is
given
crucial
role
AKG
cells
amino
synthesis,
epigenetic
regulation,
cell
stemness,
differentiation,
as
well
associated
development
conditions
and,
particular,
cancer
cells.
Another
goal
was
address
issue
terms
individual
reactivity.
also
demonstrated
Krebs
key
component
cellular
closely
various
pathologies,
such
cancer,
type
2
diabetes,
cardiovascular
or
neurodegenerative
where
mTOR
pathway
plays
role.
provides
postulates
postischaemic
phenomena
an
organism
demonstrates
dependence
accelerated
pathology
on
studies
species
(roundworm
Caenorhabditis
elegans,
Drosophila,
mice,
humans
used
models).
The
findings
suggest
that
this
approach
may
useful
show
metabolites
involved
abnormalities
thus
induce
reprogramming
contributes
senile
phenotype
degenerative
diseases.
compounds
particularly
important
when
considering
mechanisms
connected
initial
able
initiate
programmed
depending
intensity
oxygen
consumption,
peculiarities,
behavioural
reactions.
The Journal of Cardiovascular Aging,
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 1, 2023
Progressive
age-induced
deterioration
in
the
structure
and
function
of
cardiovascular
system
involves
cardiac
hypertrophy,
diastolic
dysfunction,
myocardial
fibrosis,
arterial
stiffness,
endothelial
dysfunction.
These
changes
are
driven
by
complex
processes
that
interconnected,
such
as
oxidative
stress,
mitochondrial
autophagy,
inflammation,
telomere
In
recent
years,
advances
research
aging,
including
wide
use
animal
models
elucidated
an
abundance
cell
signaling
pathways
involved
these
brought
into
sight
possible
interventions,
which
span
from
pharmacological
agents,
metformin,
sodium-glucose
cotransporter
2-inhibitors,
rapamycin,
dasatinib
quercetin,
to
lifestyle
changes.
Military Medical Research,
Год журнала:
2023,
Номер
10(1)
Опубликована: Окт. 13, 2023
Abstract
Hypoxic-ischemic
injury
is
a
common
pathological
dysfunction
in
clinical
settings.
Mitochondria
are
sensitive
organelles
that
readily
damaged
following
ischemia
and
hypoxia.
Dynamin-related
protein
1
(Drp1)
regulates
mitochondrial
quality
cellular
functions
via
its
oligomeric
changes
multiple
modifications,
which
plays
role
mediating
the
induction
of
organ
damage
during
hypoxic-ischemic
injury.
However,
there
active
controversy
gaps
knowledge
regarding
modification,
interaction,
Drp1,
both
hinder
promote
development
Drp1
as
novel
therapeutic
target.
Here,
we
summarize
recent
findings
on
changes,
modification
types,
interactions
various
diseases,
well
Drp1-mediated
regulation
cell
Additionally,
potential
translation
prospects
for
targeting
discussed.
This
review
provides
new
ideas
targets
proactive
interventions
induced
by
diseases.
Life Sciences,
Год журнала:
2024,
Номер
345, С. 122594 - 122594
Опубликована: Март 25, 2024
A
large
number
of
patients
are
affected
by
classical
heart
failure
(HF)
symptomatology
with
preserved
ejection
fraction
(HFpEF)
and
multiorgan
syndrome.
Due
to
high
morbidity
mortality
rate,
hospitalization
remain
serious
socioeconomic
problems,
while
the
lack
effective
pharmacological
or
device
treatment
means
that
HFpEF
presents
a
major
unmet
medical
need.
Evidence
from
clinical
basic
studies
demonstrates
systemic
inflammation,
increased
oxidative
stress,
impaired
mitochondrial
function
common
pathological
mechanisms
in
HFpEF.
Tetrahydrobiopterin
(BH4),
beyond
being
an
endogenous
co-factor
for
catalyzing
conversion
some
essential
biomolecules,
has
capacity
prevent
enhance
antioxidant
resistance,
modulate
energy
production.
Therefore,
BH4
emerged
last
decade
as
promising
agent
reverse
progression
disorders
such
cardiovascular
disease.
In
this
review,
we
cover
progress
limitations
using
downstream
targets
nitric
oxide
(NO)
through
NO
donors,
soluble
guanylate
cyclase
activators,
phosphodiesterase
inhibitors,
sodium-glucose
co-transporter
2
inhibitors
treating
diseases,
including
We
discuss
use
association
HFpEF,
providing
new
evidence
its
potential
option
Pharmacological Research,
Год журнала:
2024,
Номер
209, С. 107468 - 107468
Опубликована: Окт. 18, 2024
Myocardial
infarction
(MI)
remains
a
leading
cause
of
mortality
worldwide.
Despite
patients
with
MI
benefit
from
timely
reperfusion
therapies,
the
rates
and
morbidity
remain
substantial,
suggesting
an
enduring
need
for
development
new
approaches.
Molecular
mechanisms
underlying
myocardial
ischemic
injury
are
associated
both
cardiomyocytes
non-cardiomyocytes.
Exosomes
nano-sized
extracellular
vesicles
released
by
almost
all
eukaryotic
cells.
They
facilitate
communication
between
various
cells
transferring
information
via
their
cargo
altering
different
biological
activities
in
recipient
Studies
have
created
great
prospects
therapeutic
applications
exosomes
MI,
as
demonstrated
through
beneficial
effect
on
heart
function
reducing
ventricular
remodeling
association
fibrosis,
angiogenesis,
apoptosis,
inflammation.
Of
note,
is
primarily
due
to
restricted
blood
flow,
oxygen
availability,
causing
inefficient
utilization
energy
substrates.
However,
impact
cardiac
metabolism
has
not
been
adequately
investigated.
Although
engineered
targeted
delivery
enhance
clinical
efficacy,
challenges
must
be
overcome
utilize
them
reliably
clinic.
In
this
review,
we
summarize
research
progress
focus
known
unknown
regarding
role
non-cardiomyocytes;
well
potential
avenues
exosome-mitochondrial
regulation
challenges.
We
aim
help
identify
more
efficient
molecular
targets
that
may
promote
application
exosomes.
Precision Clinical Medicine,
Год журнала:
2023,
Номер
6(1)
Опубликована: Март 1, 2023
Abstract
Precision
cardiology
aims
to
implement
personalized
health
care
and
precise
medical
decisions
based
on
the
specific
characteristics
of
individuals.
Metabolic
remodeling
plays
a
causal
role
in
pathogenesis
heart
failure
(HF).
Changes
metabolic
pathways
such
as
substrate
preference,
high-energy
phosphate
metabolism
amino
acid
metabolism,
are
involved
pathological
structural
functional
impairment.
These
alterations
usually
not
restricted
cardiac
tissue,
but
also
manifest
circulation.
In
clinical
practice,
blood
sample
is
routinely
used
for
HF
screening.
Metabolomics
an
emerging
omics
technology
that
provides
efficient
way
acquire
dynamic
profiles
An
increasing
number
biomarkers
have
been
implicated
disease
progression,
making
it
possible
fight
more
effective
way.
This
review
summarizes
modern
analytical
techniques
metabolomics
well
circulating
metabolites
during
HF,
aiming
provide
new
insights
into
prevention,
diagnosis
treatment
era
precision
medicine.
American Journal of Translational Research,
Год журнала:
2024,
Номер
16(5), С. 1991 - 2000
Опубликована: Янв. 1, 2024
Heart
failure
poses
a
significant
threat
to
global
public
health
within
the
realm
of
cardiovascular
diseases.Its
pathological
progression
involves
various
alterations
in
cardiomyocytes,
among
which
autophagy,
crucial
intracellular
degradation
mechanism,
plays
pivotal
role.Autophagy
facilitates
breakdown
damaged
organelles
and
proteins,
thereby
maintaining
cellular
homeostasis.In
context
heart
failure,
autophagy
coexists
with
apoptosis
necrosis,
influencing
myocardial
hypertrophy
ventricular
remodeling.However,
its
impact
on
manifests
dual
nature:
moderate
aids
cardiac
repair,
whereas
excessive
may
exacerbate
remodeling
cell
demise.This
review
delves
into
fundamental
biology
elucidating
involvement
cascade
correlation
remodeling.Furthermore,
an
analysis
interplay
between
regulatory
factors
sheds
light
potential
therapeutic
implications
prevention
management
failure.This
exploration
provides
theoretical
foundation
for
novel
treatment
strategies
combating
failure.
